CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041689
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Chloride intracellular channel 4, isoform CRA_b 
Protein Synonyms/Alias
 Chloride intracellular channel protein 4 
Gene Name
 Clic4 
Gene Synonyms/Alias
 rCG_30947 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
62TTVDLKRKPADLQNLacetylation[1]
106LCPPKYLKLSPKHPEacetylation[1]
130AKFSAYIKNSRPEANacetylation[1]
146ALERGLLKTLQKLDEacetylation[1]
199LPKLHIVKVVAKKYRacetylation[1]
199LPKLHIVKVVAKKYRubiquitination[2]
212YRNFDIPKGMTGIWRacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 253 AA 
Protein Sequence
MALSMPLNGL KEEDKEPLIE LFVKAGSDGE SIGNCPFSQR LFMILWLKGV VFSVTTVDLK 60
RKPADLQNLA PGTHPPFITF NSEVKTDVNK IEEFLEEVLC PPKYLKLSPK HPESNTAGMD 120
IFAKFSAYIK NSRPEANEAL ERGLLKTLQK LDEYLNSPLP DEIDENSMED IKSSTRRFLD 180
GDEMTLADCN LLPKLHIVKV VAKKYRNFDI PKGMTGIWRY LTNAYSRDEF TNTCPSDKEV 240
EIAYSDVAKR LTK 253 
Gene Ontology
 GO:0045177; C:apical part of cell; IEA:Compara.
 GO:0009986; C:cell surface; IEA:Compara.
 GO:0005911; C:cell-cell junction; IEA:Compara.
 GO:0005813; C:centrosome; IEA:Compara.
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0005902; C:microvillus; IEA:Compara.
 GO:0030496; C:midbody; IEA:Compara.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0016363; C:nuclear matrix; IEA:Compara.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:Compara.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0005773; C:vacuole; IEA:Compara.
 GO:0005247; F:voltage-gated chloride channel activity; IEA:InterPro.
 GO:0001525; P:angiogenesis; IEA:Compara.
 GO:0048754; P:branching morphogenesis of an epithelial tube; IEA:Compara.
 GO:0071277; P:cellular response to calcium ion; IEA:Compara.
 GO:0001886; P:endothelial cell morphogenesis; IEA:Compara.
 GO:0009566; P:fertilization; IEA:Compara.
 GO:0030216; P:keratinocyte differentiation; IEA:Compara.
 GO:0035264; P:multicellular organism growth; IEA:Compara.
 GO:0030336; P:negative regulation of cell migration; IEA:Compara.
 GO:0061299; P:retina vasculature morphogenesis in camera-type eye; IEA:Compara.
 GO:0007035; P:vacuolar acidification; IEA:Compara. 
Interpro
 IPR010987; Glutathione-S-Trfase_C-like.
 IPR017933; Glutathione_S_Trfase/Cl_chnl_C.
 IPR002946; Int_Cl_channel.
 IPR012336; Thioredoxin-like_fold. 
Pfam
  
SMART
  
PROSITE
 PS50405; GST_CTER 
PRINTS
 PR01263; INTCLCHANNEL.