CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005123
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Ferrochelatase, mitochondrial 
Protein Synonyms/Alias
 Heme synthase; Protoheme ferro-lyase 
Gene Name
 FECH 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
112MTLPIQNKLAPFIAKubiquitination[1]
310YRLVWQSKVGPMPWLubiquitination[2]
421NPVCRETKSFFTSQQubiquitination[2]
Reference
 [1] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 Catalyzes the ferrous insertion into protoporphyrin IX. 
Sequence Annotation
 ACT_SITE 230 230
 ACT_SITE 383 383
 METAL 196 196 Iron-sulfur (2Fe-2S).
 METAL 403 403 Iron-sulfur (2Fe-2S).
 METAL 406 406 Iron-sulfur (2Fe-2S).
 METAL 411 411 Iron-sulfur (2Fe-2S).  
Keyword
 2Fe-2S; 3D-structure; Alternative splicing; Complete proteome; Disease mutation; Heme biosynthesis; Iron; Iron-sulfur; Lyase; Membrane; Metal-binding; Mitochondrion; Mitochondrion inner membrane; Polymorphism; Porphyrin biosynthesis; Reference proteome; Transit peptide. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 423 AA 
Protein Sequence
MRSLGANMAA ALRAAGVLLR DPLASSSWRV CQPWRWKSGA AAAAVTTETA QHAQGAKPQV 60
QPQKRYESNI RKPKTGILML NMGGPETLGD VHDFLLRLFL DRDLMTLPIQ NKLAPFIAKR 120
RTPKIQEQYR RIGGGSPIKI WTSKQGEGMV KLLDELSPNT APHKYYIGFR YVHPLTEEAI 180
EEMERDGLER AIAFTQYPQY SCSTTGSSLN AIYRYYNQVG RKPTMKWSTI DRWPTHHLLI 240
QCFADHILKE LDHFPLEKRS EVVILFSAHS LPMSVVNRGD PYPQEVSATV QKVMERLEYC 300
NPYRLVWQSK VGPMPWLGPQ TDESIKGLCE RGRKNILLVP IAFTSDHIET LYELDIEYSQ 360
VLAKECGVEN IRRAESLNGN PLFSKALADL VHSHIQSNEL CSKQLTLSCP LCVNPVCRET 420
KSFFTSQQL 429 
Gene Ontology
 GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
 GO:0005759; C:mitochondrial matrix; TAS:Reactome.
 GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:UniProtKB-KW.
 GO:0004325; F:ferrochelatase activity; IDA:BHF-UCL.
 GO:0008198; F:ferrous iron binding; TAS:ProtInc.
 GO:0020037; F:heme binding; IEA:Compara.
 GO:0030350; F:iron-responsive element binding; IEA:Compara.
 GO:0008203; P:cholesterol metabolic process; IEA:Compara.
 GO:0009589; P:detection of UV; IEA:Compara.
 GO:0030218; P:erythrocyte differentiation; IEA:Compara.
 GO:0006091; P:generation of precursor metabolites and energy; TAS:ProtInc.
 GO:0006783; P:heme biosynthetic process; TAS:Reactome.
 GO:0055072; P:iron ion homeostasis; IEA:Compara.
 GO:0046501; P:protoporphyrinogen IX metabolic process; IDA:BHF-UCL.
 GO:0010999; P:regulation of eIF2 alpha phosphorylation by heme; IEA:Compara.
 GO:0046984; P:regulation of hemoglobin biosynthetic process; IEA:Compara.
 GO:0009416; P:response to light stimulus; TAS:ProtInc.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome.
 GO:0034379; P:very-low-density lipoprotein particle assembly; IEA:Compara. 
Interpro
 IPR001015; Ferrochelatase.
 IPR019772; Ferrochelatase_AS. 
Pfam
 PF00762; Ferrochelatase 
SMART
  
PROSITE
 PS00534; FERROCHELATASE 
PRINTS