CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-029754
UniProt Accession
Genbank Protein ID
 Z82244 
Genbank Nucleotide ID
  
Protein Name
 Heme oxygenase 1 
Protein Synonyms/Alias
  
Gene Name
 HMOX1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
18QDLSEALKEATKEVHubiquitination[1]
39EFMRNFQKGQVTRDGubiquitination[1]
69EEEIERNKESPVFAPubiquitination[1]
86FPEELHRKAALEQDLubiquitination[1, 2]
148LSGGQVLKKIAQKALubiquitination[1, 2]
153VLKKIAQKALDLPSSubiquitination[1, 2, 3]
177PNIASATKFKQLYRSubiquitination[1, 2]
179IASATKFKQLYRSRMubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 187 AA 
Protein Sequence
MERPQPDSMP QDLSEALKEA TKEVHTQAEN AEFMRNFQKG QVTRDGFKLV MASLYHIYVA 60
LEEEIERNKE SPVFAPVYFP EELHRKAALE QDLAFWYGPR WQEVIPYTPA MQRYVKRLHE 120
VGRTEPELLV AHAYTRYLGD LSGGQVLKKI AQKALDLPSS GEGLAFFTFP NIASATKFKQ 180
LYRSRMN 187 
Gene Ontology
 GO:0005901; C:caveola; IEA:Compara.
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0005783; C:endoplasmic reticulum; IEA:Compara.
 GO:0005730; C:nucleolus; IEA:Compara.
 GO:0020037; F:heme binding; IEA:Compara.
 GO:0004392; F:heme oxygenase (decyclizing) activity; IEA:Compara.
 GO:0004630; F:phospholipase D activity; IEA:Compara.
 GO:0001525; P:angiogenesis; IEA:Compara.
 GO:0071276; P:cellular response to cadmium ion; IEA:Compara.
 GO:0031670; P:cellular response to nutrient; IEA:Compara.
 GO:0042167; P:heme catabolic process; IEA:Compara.
 GO:0006788; P:heme oxidation; IEA:InterPro.
 GO:0008630; P:intrinsic apoptotic signaling pathway in response to DNA damage; IEA:Compara.
 GO:0043392; P:negative regulation of DNA binding; IEA:Compara.
 GO:0032764; P:negative regulation of mast cell cytokine production; IEA:Compara.
 GO:0043305; P:negative regulation of mast cell degranulation; IEA:Compara.
 GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Compara.
 GO:0043433; P:negative regulation of sequence-specific DNA binding transcription factor activity; IEA:Compara.
 GO:0048662; P:negative regulation of smooth muscle cell proliferation; IEA:Compara.
 GO:0045766; P:positive regulation of angiogenesis; IEA:Compara.
 GO:0008217; P:regulation of blood pressure; IEA:Compara.
 GO:0043619; P:regulation of transcription from RNA polymerase II promoter in response to oxidative stress; IEA:Compara.
 GO:0043627; P:response to estrogen stimulus; IEA:Compara.
 GO:0042542; P:response to hydrogen peroxide; IEA:Compara.
 GO:0001666; P:response to hypoxia; IEA:Compara.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:Compara. 
Interpro
 IPR002051; Haem_Oase.
 IPR016053; Haem_Oase-like.
 IPR016084; Haem_Oase-like_multi-hlx.
 IPR018207; Haem_oxygenase_CS. 
Pfam
 PF01126; Heme_oxygenase 
SMART
  
PROSITE
 PS00593; HEME_OXYGENASE 
PRINTS
 PR00088; HAEMOXYGNASE.