| Tag | Content |
|---|
| CPLM ID | CPLM-011282 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Max dimerization protein 1 |
Protein Synonyms/Alias | Max dimerizer 1; Protein MAD |
Gene Name | MXD1 |
Gene Synonyms/Alias | MAD |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 135 | HLKRQLEKLGIERIR | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Transcriptional repressor. MAD binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. MAD thus antagonizes MYC transcriptional activity by competing for MAX. |
Sequence Annotation | DOMAIN 56 108 bHLH.
MOTIF 21 49 Nuclear localization signal (Potential). |
Keyword | 3D-structure; Alternative splicing; Complete proteome; DNA-binding; Nucleus; Reference proteome; Repressor; Transcription; Transcription regulation; Ubl conjugation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 221 AA |
Protein Sequence | MAAAVRMNIQ MLLEAADYLE RREREAEHGY ASMLPYNNKD RDALKRRNKS KKNNSSSRST 60
HNEMEKNRRA HLRLCLEKLK GLVPLGPESS RHTTLSLLTK AKLHIKKLED CDRKAVHQID 120
QLQREQRHLK RQLEKLGIER IRMDSIGSTV SSERSDSDRE EIDVDVESTD YLTGDLDWSS 180
SSVSDSDERG SMQSLGSDEG YSSTSIKRIK LQDSHKACLG L 221 |
Gene Ontology | GO:0005739; C:mitochondrion; IDA:HPA. GO:0005634; C:nucleus; IDA:HPA. GO:0003677; F:DNA binding; IEA:UniProtKB-KW. GO:0003700; F:sequence-specific DNA binding transcription factor activity; TAS:ProtInc. GO:0003714; F:transcription corepressor activity; TAS:ProtInc. GO:0008283; P:cell proliferation; TAS:ProtInc. GO:0007275; P:multicellular organismal development; TAS:ProtInc. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
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PRINTS | |