| Tag | Content |
|---|
| CPLM ID | CPLM-009124 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | E3 ubiquitin-protein ligase RNF216 |
Protein Synonyms/Alias | RING finger protein 216; Triad domain-containing protein 3; UbcM4-interacting protein 83; Ubiquitin-conjugating enzyme 7-interacting protein 1 |
Gene Name | Rnf216 |
Gene Synonyms/Alias | Triad3; Ubce7ip1; Uip83; Zin |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 350 | IDFFDYSKLTPLDQR | ubiquitination | [1] | | 464 | QALLPAVKQEQEFYE | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Acts as an E3 ubiquitin ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Promotes degradation of TRAF3, TLR4 and TLR9. Contributes to the regulation of antiviral responses. Down-regulates activation of NF-kappa-B, IRF3 activation and IFNB production. Promotes TNF and RIP mediated apoptosis (By similarity). |
Sequence Annotation | ZN_FING 503 554 RING-type 1.
ZN_FING 571 636 IBR-type.
ZN_FING 663 702 RING-type 2. |
Keyword | Alternative splicing; Apoptosis; Coiled coil; Complete proteome; Cytoplasm; Ligase; Metal-binding; Reference proteome; Repeat; Ubl conjugation; Ubl conjugation pathway; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 853 AA |
Protein Sequence | MAEGNNKEEV IHLNNFPCHR GKEWMAVREG PITISDSSDE EGIPMLVTPA TEQQEDDLDD 60
DVILTEDDSE DEYGGFLDLE SGKKEGEAKP GPSSKQTADD IVNPRLEQKV IILGENGLLF 120
PESEPLEVQN QSSEDSETEL LSNPGEPAAS VDDQLIGEEY WLDHPYFQAP NPQPQERTNQ 180
VVPQERHSES EMGPMFFRHD FPEPAFPRPE PQQEGIPGPA SPQPAHPLGE LEDQQLAIDE 240
DPGPAFPLSG PQEANLANMW EQEAAEVDQD LIPLLVKETE ARFPDVASGY VEEIIHLKNY 300
YDLNVLCNFL LENPDYPKRE DRLIIHPSSS LLASQDDAKL PKIDFFDYSK LTPLDQRCFI 360
QAADLLMADF KMLSSQDIKW ALHELKGHYA ITRKAFSDAI KKWQELSPET SGKRKKRKEM 420
NQYSFIDFKF EQGNIKIEKR MFFLENKRRH CRYYDHQALL PAVKQEQEFY EQKIKEMAEH 480
EDFLLALQMN EEQYQKDGQL IECRCCYGEF PFEELTQCAD AHLFCKECLI RYAQEAVFGS 540
GKSELSCMEG SCTCSFPTSE LEKVLPQTIL YKYYERKAEE EVAAAYADEL VRCPSCSFPA 600
LLDSDVKRFS CPNPRCRKET CRKCQGLWKE HNGLTCEELA EKDDIKYRTS IEEKMTAARI 660
RKCHKCGTGL IKSEGCNRMS CRCGAQMCYL CRVSINGYDH FCQHPRSPGA PCQECSRCSL 720
WTDPTEDDEK LIEEIQKEAE EEQKRKNGEN TFKRIGPPLE KPAEKVQRVE ALPRPVPQNL 780
HPQMPPYAFV HPPFPLPPVR PVFNNFPINM GPVPAPYVPP LPNVRVNYDF GHMHVPLEHN 840
LPMHFGPQPR HRF 853 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0005634; C:nucleus; IEA:Compara. GO:0016874; F:ligase activity; IEA:UniProtKB-KW. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0006915; P:apoptotic process; IEA:UniProtKB-KW. GO:0043161; P:proteasomal ubiquitin-dependent protein catabolic process; ISS:UniProtKB. GO:0070936; P:protein K48-linked ubiquitination; ISS:UniProtKB. GO:0050691; P:regulation of defense response to virus by host; ISS:UniProtKB. GO:0032648; P:regulation of interferon-beta production; ISS:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |