UniProt Accession

 EPHB2_HUMAN; P29323; O43477; Q5T0U6; Q5T0U7; Q5T0U8 

Genbank Protein ID

 D31661; L41939; AF025304; AL035704; AL158086; AL512444; AL035704; AL158086; AL512444; AL035704; AL158086; AL512444; AL158086; AL035704; AL512444; AL158086; AL512444; AL035704; AL158086; AL035704; AL512444; AL512444; AL035704; AL158086; AL512444; AL035704; AL158086; AL512444; AL035704; AL158086; L36643; D37827; D14717; X59292 

Genbank Nucleotide ID

 BAA06506.1; AAA99310.1; AAB94602.1; CAI22645.1; CAI22645.1; CAI22645.1; CAI22646.1; CAI22646.1; CAI22646.1; CAI22647.2; CAI22647.2; CAI22647.2; CAI22897.1; CAI22897.1; CAI22897.1; CAI22898.1; CAI22898.1; CAI22898.1; CAI22899.2; CAI22899.2; CAI22899.2; CAI16428.1; CAI16428.1; CAI16428.1; CAI16429.1; CAI16429.1; CAI16429.1; CAI16430.2; CAI16430.2; CAI16430.2; AAA74244.1; BAA07073.1; BAA03537.1; CAA41981.1 

Protein Name

 Ephrin type-B receptor 2 

Protein Synonyms/Alias

 Developmentally-regulated Eph-related tyrosine kinase; ELK-related tyrosine kinase; EPH tyrosine kinase 3; EPH-like kinase 5; EK5; hEK5; Renal carcinoma antigen NY-REN-47; Tyrosine-protein kinase TYRO5; Tyrosine-protein kinase receptor EPH-3 

Gene Name

 EPHB2 

Gene Synonyms/Alias

 DRT; EPHT3; EPTH3; ERK; HEK5; TYRO5 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
580	ADSEYTDKLQHYTSG	ubiquitination	[1]

Reference

 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 

Functional Description

 Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Functions in axon guidance during development. Involved in the guidance of commissural axons, that form a major interhemispheric connection between the 2 temporal lobes of the cerebral cortex. Also involved in guidance of contralateral inner ear efferent growth cones at the midline and of retinal ganglion cell axons to the optic disk. Beside axon guidance, also regulates dendritic spines development and maturation and stimulates the formation of excitatory synapses. Upon activation by EFNB1, abolishes the ARHGEF15-mediated negative regulation on excitatory synapse formation. Controls other aspects of development including angiogenesis, palate development and in inner ear development through regulation of endolymph production. Forward and reverse signaling through the EFNB2/EPHB2 complex regulate movement and adhesion of cells that tubularize the urethra and septate the cloaca. May function as a tumor suppressor. 

Sequence Annotation

 DOMAIN 20 202 Eph LBD.
 DOMAIN 325 426 Fibronectin type-III 1.
 DOMAIN 432 527 Fibronectin type-III 2.
 DOMAIN 621 884 Protein kinase.
 DOMAIN 913 977 SAM.
 NP_BIND 627 635 ATP (By similarity).
 MOTIF 984 986 PDZ-binding (in isoform 2) (Potential).
 ACT_SITE 746 746 Proton acceptor (By similarity).
 BINDING 653 653 ATP (By similarity).
 CARBOHYD 265 265 N-linked (GlcNAc...) (Potential).
 CARBOHYD 336 336 N-linked (GlcNAc...) (Potential).
 CARBOHYD 428 428 N-linked (GlcNAc...) (Potential).
 CARBOHYD 482 482 N-linked (GlcNAc...) (Potential).
 DISULFID 62 184
 DISULFID 97 107  

Keyword

 3D-structure; Alternative splicing; ATP-binding; Cell membrane; Cell projection; Complete proteome; Developmental protein; Disease mutation; Disulfide bond; Glycoprotein; Kinase; Membrane; Neurogenesis; Nucleotide-binding; Phosphoprotein; Polymorphism; Receptor; Reference proteome; Repeat; Signal; Transferase; Transmembrane; Transmembrane helix; Tumor suppressor; Tyrosine-protein kinase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 1055 AA 

Protein Sequence

Gene Ontology

 GO:0030424; C:axon; ISS:UniProtKB.
 GO:0030425; C:dendrite; ISS:UniProtKB.
 GO:0005887; C:integral to plasma membrane; ISS:UniProtKB.
 GO:0043025; C:neuronal cell body; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0008046; F:axon guidance receptor activity; IEA:Compara.
 GO:0005005; F:transmembrane-ephrin receptor activity; ISS:UniProtKB.
 GO:0001525; P:angiogenesis; ISS:UniProtKB.
 GO:0007413; P:axonal fasciculation; ISS:UniProtKB.
 GO:0048593; P:camera-type eye morphogenesis; IEA:Compara.
 GO:0021952; P:central nervous system projection neuron axonogenesis; IEA:Compara.
 GO:0071679; P:commissural neuron axon guidance; ISS:UniProtKB.
 GO:0022038; P:corpus callosum development; ISS:UniProtKB.
 GO:0060997; P:dendritic spine morphogenesis; ISS:UniProtKB.
 GO:0042472; P:inner ear morphogenesis; ISS:UniProtKB.
 GO:0007612; P:learning; IEA:Compara.
 GO:0050771; P:negative regulation of axonogenesis; IEA:Compara.
 GO:0021631; P:optic nerve morphogenesis; IEA:Compara.
 GO:0060021; P:palate development; ISS:UniProtKB.
 GO:0018108; P:peptidyl-tyrosine phosphorylation; ISS:UniProtKB.
 GO:0048170; P:positive regulation of long-term neuronal synaptic plasticity; IEA:Compara.
 GO:0051965; P:positive regulation of synapse assembly; ISS:UniProtKB.
 GO:0050878; P:regulation of body fluid levels; ISS:UniProtKB.
 GO:0031290; P:retinal ganglion cell axon guidance; IEA:Compara.
 GO:0001655; P:urogenital system development; ISS:UniProtKB. 

Interpro

 IPR001090; Ephrin_rcpt_lig-bd_dom.
 IPR003961; Fibronectin_type3.
 IPR008979; Galactose-bd-like.
 IPR009030; Growth_fac_rcpt_N_dom.
 IPR013783; Ig-like_fold.
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR001660; SAM.
 IPR013761; SAM/pointed.
 IPR021129; SAM_type1.
 IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
 IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
 IPR008266; Tyr_kinase_AS.
 IPR020635; Tyr_kinase_cat_dom.
 IPR016257; Tyr_kinase_ephrin_rcpt.
 IPR001426; Tyr_kinase_rcpt_V_CS. 

Pfam

 PF01404; Ephrin_lbd
 PF00041; fn3
 PF07699; GCC2_GCC3
 PF07714; Pkinase_Tyr
 PF00536; SAM_1 

SMART

 SM00615; EPH_lbd
 SM00060; FN3
 SM00454; SAM
 SM00219; TyrKc 

PROSITE

 PS51550; EPH_LBD
 PS50853; FN3
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00109; PROTEIN_KINASE_TYR
 PS00790; RECEPTOR_TYR_KIN_V_1
 PS00791; RECEPTOR_TYR_KIN_V_2
 PS50105; SAM_DOMAIN 

PRINTS

 PR00109; TYRKINASE.