CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041687
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein Itch 
Protein Synonyms/Alias
  
Gene Name
 Itch 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
182VAASGENKRANGNNSubiquitination[1]
397PLPPGWEKRTDSNGRubiquitination[1]
429SQGQLNEKPLPEGWEubiquitination[1]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Ligase; Reference proteome; Ubl conjugation pathway. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 853 AA 
Protein Sequence
MGSLTMKSQL QITVISAKLK ENKKNWFGPS PYVEVTVDGQ SKKTEKCNNT NSPKWKQPLT 60
VIVTPMSKLC FRVWSHQTLK SDVLLGTAGL DIYETLKSNN MKLEEVVMTL QLVGDKEPTE 120
TMGDLSVCLD GLQVEAEVVT NGETSCSEGA TQNDAGCRPK DETRVSTNGS EDPEVAASGE 180
NKRANGNNSP SLSNGGFKPS RPPRPSRPPP PTPRRPASVN GSPSTNSDSD GSSTGSLPPT 240
NTNVNSSASE GAASGLIIPL TISGGSGPRP LNTVSQAPLP PGWEQRVDQH GRVYYVDHVE 300
KRTTWDRPEP LPPGWERRVD NMGRIYYVDH FTRTTTWQRP TLESVRNYEQ WQLQRSQLQG 360
AMQQFNQRFI FGNQDLFATS QNKEFDPLGP LPPGWEKRTD SNGRVYFVNH NTRITQWEDP 420
RSQGQLNEKP LPEGWEMRFT VDGIPFVDHN RRATTYIDPR TGKSALDNGP QIAYVRDFKA 480
KVQYFRFWCQ QLAMPQHIKI TVTRKTLFED SFQQIMSFSP QDLRRRLWVI FPGEEGLDYG 540
GVAREWFFLL SHEVLNPMYC LFEYAGKDNY CLQINPASYI NPDHLKYFRF IGRFIAMALF 600
HGKFIDTGFS LPFYKRILNK PVGLKDLESI DPEFYNSLIW VKENNIEECG LEMYFSVDKE 660
ILGEIKSHDL KPNGGNILVT EENKEEYIRM VAEWRLSRGV EEQTQAFFEG FNEILPQQYL 720
QYFDAKELEV LLCGMQEIDL NDWQRHAIYR HYTRTSKQIV WFWQFVKEID NEKRMRLLQF 780
VTGTCRLPVG GFADLMGSNG PQKFCIEKVG KENWLPRSHT CFNRLDLPPY KSYEQLKEKL 840
LFAIEETEGF GQE 853 
Gene Ontology
 GO:0005938; C:cell cortex; IEA:Compara.
 GO:0005737; C:cytoplasm; IBA:RefGenome.
 GO:0031410; C:cytoplasmic vesicle; IEA:Compara.
 GO:0005634; C:nucleus; IBA:RefGenome.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0043021; F:ribonucleoprotein complex binding; IEA:Compara.
 GO:0004842; F:ubiquitin-protein ligase activity; IBA:RefGenome.
 GO:0046642; P:negative regulation of alpha-beta T cell proliferation; IEA:Compara.
 GO:0043066; P:negative regulation of apoptotic process; IEA:Compara.
 GO:0050687; P:negative regulation of defense response to virus; IEA:Compara.
 GO:0046329; P:negative regulation of JNK cascade; IEA:Compara.
 GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; IEA:Compara.
 GO:0045732; P:positive regulation of protein catabolic process; IEA:Compara.
 GO:0002669; P:positive regulation of T cell anergy; IEA:Compara.
 GO:0035519; P:protein K29-linked ubiquitination; IEA:Compara.
 GO:0070936; P:protein K48-linked ubiquitination; IEA:Compara.
 GO:0070534; P:protein K63-linked ubiquitination; IEA:Compara.
 GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome.
 GO:0090085; P:regulation of protein deubiquitination; IEA:Compara. 
Interpro
 IPR000008; C2_Ca-dep.
 IPR008973; C2_Ca/lipid-bd_dom_CaLB.
 IPR018029; C2_membr_targeting.
 IPR024928; E3_ub_ligase_SMURF1.
 IPR000569; HECT.
 IPR001202; WW_dom. 
Pfam
 PF00168; C2
 PF00632; HECT
 PF00397; WW 
SMART
 SM00239; C2
 SM00119; HECTc
 SM00456; WW 
PROSITE
 PS50004; C2
 PS50237; HECT
 PS01159; WW_DOMAIN_1
 PS50020; WW_DOMAIN_2 
PRINTS