CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017177
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Aldo-keto reductase family 1 member C18 
Protein Synonyms/Alias
 20-alpha-hydroxysteroid dehydrogenase; 20-alpha-HSD 
Gene Name
 Akr1c18 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
75KIEDGTVKREDIFYTubiquitination[1]
179QLEMILNKPGLKYKPubiquitination[1]
270RGIVALAKSFNEERIubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Catalyzes the conversion of progesterone into 20-alpha- dihydroprogesterone (20 alpha-OHP). 
Sequence Annotation
 NP_BIND 13 22 NADP (Potential).
 NP_BIND 217 280 NADP (By similarity).
 ACT_SITE 55 55 Proton donor (By similarity).
 BINDING 117 117 Substrate (By similarity).  
Keyword
 Alternative splicing; Complete proteome; Cytoplasm; NADP; Oxidoreductase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 323 AA 
Protein Sequence
MNSKIQKIEL NDGHSIPVLG FGTYATEEHL KKKSMESTKI AIDVGFCHID CSHLYQNEEE 60
IGQAILSKIE DGTVKREDIF YTSKLWSTSH RPELVRPSLE NSLRKLNLDY VDLYLIHFPV 120
SLKPGNELLP KDEHGNLIFD TVDLCDTWEA MEKCKDAGLA KSIGVSNFNR RQLEMILNKP 180
GLKYKPVCNQ VECHLYLNQS KLLAYCKMND IVLVAYGALG TQRYKYCINE DTPVLLDDPV 240
LCAMAKKYKR TPALIALRYQ LDRGIVALAK SFNEERIREN MQVFDFQLAS DDMKILDGLD 300
RNLRYFPADM FKAHPNFPFF DEY 323 
Gene Ontology
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0047006; F:17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity; IDA:MGI.
 GO:0007567; P:parturition; IMP:MGI.
 GO:0006709; P:progesterone catabolic process; IDA:MGI.
 GO:0050810; P:regulation of steroid biosynthetic process; IEA:Compara. 
Interpro
 IPR001395; Aldo/ket_red.
 IPR018170; Aldo/ket_reductase_CS.
 IPR020471; Aldo/keto_reductase_subgr.
 IPR023210; NADP_OxRdtase_dom. 
Pfam
 PF00248; Aldo_ket_red 
SMART
  
PROSITE
 PS00062; ALDOKETO_REDUCTASE_2
 PS00063; ALDOKETO_REDUCTASE_3 
PRINTS
 PR00069; ALDKETRDTASE.