Tag | Content |
---|
CPLM ID | CPLM-037392 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Nesprin-1 |
Protein Synonyms/Alias | |
Gene Name | SYNE1 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
---|
3804 | EKGLHLAKEFSDKCK | ubiquitination | [1] | 5051 | ELMNDTEKKLSEFSL | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | |
Sequence Annotation | |
Keyword | Actin-binding; Complete proteome; Reference proteome; Repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 8749 AA |
Protein Sequence | MATSRGASRC PRDIANVMQR LQDEQEIVQK RTFTKWINSH LAKRKPPMVV DDLFEDMKDG 60 VKLLALLEVL SGQKLPCEQG RRMKRIHAVA NIGTALKFLE GRKSMHRGSP IKLVNINSTD 120 IADGRPSIVL GLMWTIILYF QIEELTSNLP QLQSLSSSAS SVDSIVSSET PSPPSKRKVT 180 TKIQGNAKKA LLKWVQYTAG KQTGIEVKDF GKSWRSGVAF HSVIHAIRPE LVDLETVKGR 240 SNRENLEDAF TIAETELGIP RLLDPEDVDV DKPDEKSIMT YVAQFLKHYP DIHNASTDGQ 300 EDDEILPGFP SFANSVQNFK REDRVIFKEM KVWIEQFERD LTRAQMVESN LQDKYQSFKH 360 FRVQYEMKRK QIEHLIQPLH RDGKLSLDQA LVKQSWDRVT SRLFDWHIQL DKSLPAPLGT 420 IGAWLYRAEV ALREEITVQQ VHEETANTIQ RKLEQHKDLL QNTDAHKRAF HEIYRTRSVN 480 GIPVPPDQLE DMAERFHFVS STSELHLMKM EFLELKYRLL SLLVLAESKL KSWIIKYGRR 540 ESVEQLLQNY VSFIENSKFF EQYEVTYQIL KQTAEMYVKA DGSVEEAENV MKFMNETTAQ 600 WRNLSVEVRS VRSMLEEVIS NWDRYGNTVA SLQAWLEDAE KMLNQSENAK KDFFRNLPHW 660 IQQHTAMNDA GNFLIETCDE MVSRDLKQQL LLLNGRWREL FMEVKQYAQA DEMDRMKKEY 720 TDCVVTLSAF ATEAHKKLSE PLEVSFMNVK LLIQDLEDIE QRVPVMDAQY KIITKTAHLI 780 TKESPQEEGK EMFATMSKLK EQLTKVKECY SPLLYESQQL LIPLEELEKQ MTSFYDSLGK 840 INEIITVLER EAQSSALFKQ KHQELLACQE NCKKTLTLIE KGSQSVQKFV TLSNVLKHFD 900 QTRLQRQIAD IHVAFQSMVK KTGDWKKHVE TNSRLMKKFE ESRAELEKVL RIAQEGLEEK 960 GDPEELLRRH TEFFSQLDQR VLNAFLKACD ELTDILPEQE QQGLQEAVRK LHKQWKDLQG 1020 EAPYHLLHLK IDVEKNRFLA SVEECRTELD RETKLMPQEG SEKIIKEHRV FFSDKGPHHL 1080 CEKRLQLIEE LCVKLPVRDP VRDTPGTCHV TLKELRAAID STYRKLMEDP DKWKDYTSRF 1140 SEFSSWISTN ETQLKGIKGE AIDTANHGEV KRAVEEIRNG VTKRGETLSW LKSRLKVLTE 1200 VSSENEAQKQ GDELAKLSSS FKALVTLLSE VEKMLSNFGD CVQYKEIVKN SLEELISGSK 1260 EVQEQAEKIL DTENLFEAQQ LLLHHQQKTK RISAKKRDVQ QQIAQAQQGE GGLPDRGHEE 1320 LRKLESTLDG LERSRERQER RIQVTLRKWE RFETNKETVV RYLFQTGSSH ERFLSFSSLE 1380 SLSSELEQTK EFSKRTESIA VQAENLVKEA SEIPLGPQNK QLLQQQAKSI KEQVKKLEDT 1440 LEEDIKTMEM VKTKWDHFGS NFETLSVWIT EKEKELNALE TSSSAMDMQI SQIKVTIQEI 1500 ESKLSSIVGL EEEAQSFAQF VTTGESARIK AKLTQIRRYG EELREHAQCL EGTILGHLSQ 1560 QQKFEENLRK IQQSVSEFED KLAVPIKICS SATETYKVLQ EHMDLCQALE SLSSAITAFS 1620 ASARKVVNRD SCVQEAAALQ QQYEDILRRA KERQTALENL LAHWQRLEKE LSSFLTWLER 1680 GEAKASSPEM DISADRVKVE GELQLIQASS RKFVSQASFY SKLLQLKESL FSVASKDDVK 1740 MMKLHLEQLD ERWRDLPQII NKRINFLQSV VAEHQQFDEL LLSFSVWIKL FLSELQTTSE 1800 ISIMDHQVAL TRHKDHAAEV ESKKGELQSL QGHLAKLGSL GRAEDLHLLQ GKAEDCFQLF 1860 EEASQVVERR QLALSHLAEF LQSHASLSGI LRQLRQTVEA TNSMNKNESD LIEKDLNDAL 1920 QNAKALESAA VSLDGILSKA QYHLKIGSSE QRTSCRATAD QLCGEVERIQ NLLGTKQSEA 1980 DALAVLKKAF QDQKEELLKS IEDIEERTDK ERLKEPTRQA LQQRLRVFNQ LEDELNSHEH 2040 ELCWLKDKAK QIAQKDVAFA PEVDREINRL EVTWDDTKRL IHENQGQCCG LIDLMREYQN 2100 LKSAVSKVLE NASSVIVTRT TIKDQEDLKW AFSKHETAKN KMNYKQKDLD NFTSKGKHLL 2160 SELKKIHSSD FSLVKTDMES TVDKWLDVSE KLEENMDRLR VSLSIWDDVL STRDEIEGWS 2220 NNCVPQMAEN ISNLDNHLRA EELLKEFESE VKNKALRLEE LHSKVNDLKE LTKNLETPPD 2280 LQFIEADLMQ KLEHAKEITE VAKGTLKDFT AQSTQVEKFI NDITTWFTKV EESLMNCAQN 2340 ETCEALKKVK DIQKELQSQQ SNISSTQENL NSLCRKYHSA ELESLGRAMT GLIKKHEAVS 2400 QLCSKTQASL QESLEKHFSE SMQEFQEWFL GAKAAAKESS DRTGDSKVLE AKLHDLQNIL 2460 DSVSDGQSKL DAVTQEGQTL YAHLSKQIVS SIQEQITKAN EEFQAFLKQC LKDKQALQDC 2520 ASELGSFEDQ HRKLNLWIHE MEERFNTENL GESKQHIPEK KNEVHKVEMF LGELLAARES 2580 LDKLSQRGQL LSEEGHGAGQ EGRLCSQLLT SHQNLLRMTK EKLRSCQVAL QEHEALEEAL 2640 QSMWFWVKAI QDRLACAEST LGSKDTLEKR LSQIQDILLM KGEGEVKLNM AIGKGEQALR 2700 SSNKEGQRVI QTQLETLKEV WADIMSSSVH AQSTLESVIS QWNDYVERKN QLEQWMESVD 2760 QKIEHPLQPQ PGLKEKFVLL DHLQSILSEA EDHTRALHRL IAKSRELYEK TEDESFKDTA 2820 QEELKTQFND IMTVAKEKMR KVEEIVKDHL MYLDAVHEFT DWLHSAKEEL HRWSDMSGDS 2880 SATQKKLSKI KELIDSREIG ASRLSRVESL APEVKQNTTA SGCELMHTEM QALRADWKQW 2940 EDSVFQTQSC LENLVSQMAL SEQEFSGQVA QLEQALEQFS ALLKTWAQQL TLLEGKNTDE 3000 EIVECWHKGQ EILDALQKAE PRTEDLKSQL NELCRFSRDL STYSGKVSGL IKEYNCLCLQ 3060 ASKGCQNKEQ ILQQRFRKAF RDFQQWLVNA KITTAKCFDI PQNISEVSTS LQKIQEFLSE 3120 SENGQHKLNM MLSKGELLST LLTKEKAKGI QAKVTAAKED WKNFHSNLHQ KESALENLKI 3180 QMKDFEVSAE PIQDWLSKTE KMVHESSNRL YDLPAKRREQ QKLQSVLEEI HCYEPQLNRL 3240 KEKAQQLWEG QAASKSFRHR VSQLSSQYLA LSNLTKEKVS RLDRIVAEHN QFSLGIKELQ 3300 DWMTDAIHML DSYCHPTSDK SVLDSRTLKL EALLSVKQEK EIQMKMIVTR GESVLQNTSP 3360 EGIPTIQQQL QSVKDMWASL LSAGIRCKSQ LEGALSKWTS YQDGVRQFSG WMDSMEANLN 3420 ESERQHAELR DKTTMLGKAK LLNEEVLSYS SLLETIEVKG AGMTEHYVTQ LELQDLQERY 3480 RAIQERAKEA VTKSEKLVRL HQEYQRDLKA FEVWLGQEQE KLDQYSVLEG DAHTHETTLR 3540 DLQELQVHCA EGQALLNSVL HTREDVIPSG IPQAEDRALE SLRQDWQAYQ HRLSETRTQF 3600 NNVVNKLRLM EQKFQQVDEW LKTAEEKKWH EEVTAYRDEV EEVGARAQEI LDESHVNSRM 3660 GCQATQLTSR YQALLLQVLE QIKFLEEEIQ SLEESESSLS SYSDWYGSTH KNFKNVATKI 3720 DKVDTVMMGK KLKTLEVLLK DMEKGHSLLK SAREKGERAV KYLEEGEAER LRKEIHDHME 3780 QLKELTSTVR KEHMTLEKGL HLAKEFSDKC KALTQWIAEY QEILHVPEEP KMELYEKKAQ 3840 LSKYKSLQQT VLSHEPSVKS VREKGEALLE LVQDVTLKDK IDQLQSDYQD LCSIGKAMME 3900 EIAGFEDRLN NLQMKGDTLI GQCADHLQAK LKQNVHAHLQ GTKDSYSAIC STAQRMYQSL 3960 EHELQKHVSR QDTLQQCQAW LSAVQPDLEP SPQPPLSRAE AIKQVKHFRA LQEQARTYLD 4020 LLCSMCDLSN ASVKTTAKDI QQTEQTIEQK LVQAQNLTQG WEEIKHLKSE LWIYLQDADQ 4080 QLQNMKRRHS ELELNIAQNM VSQVKDFVKK LQSKQASVNT IIEKVNKLTK KEESPEHKEI 4140 NHLNDQWLDL CRQSNNLCLQ REEDLQRTRD YHDCMNVVEV FLEKFTTEWD NLARSDAEST 4200 AVHLEALKKL ALALQERKYA IEDLKDQKQK MIEHLNLDDK ELVKEQTSHL EQRWFQLEDL 4260 IKRKIQVSVT NLEELNVVQS RFQELMEWAE EQQPNIAEAL KQSPPPDMAQ NLLMDHLAIC 4320 SELEAKQMLL KSLIKDADRV MADLGLNERQ VIQKALSDAQ SHVNCLSDLV GQRRKYLNKA 4380 LSEKTQFLMA VFQATSQIQQ HERKIMFREH ICLLPDDVSK QVKTCKSAQA SLKTYQNEVT 4440 GLWAQGRELM KEVTEQEKSE VLGKLQELQS VYDSVLQKCS HRLQELEKNL VSRKHFKEDF 4500 DKACHWLKQA DIVTFPEINL MNESSELHTQ LAKYQNILEQ SPEYENLLLT LQRTGQTILP 4560 SLNEVDHSYL SEKLNALPRQ FNVIVALAKD KFYKVQEAIL ARKEYASLIE LTTQSLSELE 4620 AQFLRMSKVP TDLAVEEALS LQDGCRAILD EVAGLGEAVD ELNQKKEGFR STGQPWQPDK 4680 MLHLVTLYHR LKRQTEQRVS LLEDTTSAYQ EHEKMCQQLE RQLKSVKEEQ SKVNEETLPA 4740 EEKLKMYHSL AGSLQDSGIV LKRVTIHLED LAPHLDPLAY EKARHQIQSW QGELKLLTSA 4800 IGETVTECES RMVQSIDFQT EMSRSLDWLR RVKAELSGPV YLDLNLQDIQ EEIRKIQIHQ 4860 EEVQSSLRIM NALSHKEKEK FTKAKELISA DLEHSLAELS ELDGDIQEAL RTRQATLTEI 4920 YSQCQRYYQV FQAANDWLED AQELLQLAGN GLDVESAEEN LKSHMEFFST EDQFHSNLEE 4980 LHSLVATLDP LIKPTGKEDL EQKVASLELR SQRMSRDSGA QVDLLQRCTA QWHDYQKARE 5040 EVIELMNDTE KKLSEFSLLK TSSSHEAEEK LSEHKALVSV VNSFHEKIVA LEEKASQLEK 5100 TGNDASKATL SRSMTTVWQR WTRLRAVAQD QEKILEDAVD EWTGFNNKVK KATEMIDQLQ 5160 DKLPGSSAEK ASKAELLTLL EYHDTFVLEL EQQQSALGML RQQTLSMLQD GAAPTPGEEP 5220 PLMQEITAMQ DRCLNMQEKV KTNGKLVKQE LKDREMVETQ INSVKCWVQE TKEYLGNPTI 5280 EIDAQLEELQ ILLTEATNHR QNIEKMAEEQ KEKYLGLYTI LPSELSLQLA EVALDLKIRD 5340 QIQDKIKEVE QSKATSQELS RQIQKLAKDL TTILTKLKAK TDNVVQAKTD QKVLGEELDG 5400 CNSKLMELDA AVQKFLEQNG QLGKPLAKKI GKLTELHQQT IRQAENRLSK LNQAASHLEE 5460 YNEMLELILK WIEKAKVLAH GTIAWNSASQ LREQYILHQT LLEESKEIDS ELEAMTEKLQ 5520 YLTSVYCTEK MSQQVAELGR ETEELRQMIK IRLQNLQDAA KDMKKFEAEL KKLQAALEQA 5580 QATLTSPEVG RLSLKEQLSH RQHLLSEMES LKPKVQAVQL CQSALRIPED VVASLPLCHA 5640 ALRLQEEASR LQHTAIQQCN IMQAAVVQYE QYEQEMKHLQ QLIEGAHREI EDKPVATSNI 5700 QELQAQISRH EELAQKIKGY QEQIASLNSK CKMLTMKAKH ATMLLTVTEV EGLAEGTEDL 5760 DGELLPTPSA HPSVVMMTAG RCHTLLSPVT EESGEEGTNS EISSPPACRS PSPVANTDAS 5820 VNQDIAYYQA LSAERLQTDA AKIHPSTSAS QEFYEPGLEP SATAKLGDLQ RSWETLKNVI 5880 SEKQRTLYEA LERQQKYQDS LQSISTKMEA IELKLSESPE PGRSPESQMA EHQALMDEIL 5940 MLQDEINELQ SSLAEELVSE SCEADPAEQL ALQSTLTVLA ERMSTIRMKA SGKRQLLEEK 6000 LNDQLEEQRQ EQALQRYRCE ADELDSWLLS TKATLDTALS PPKEPMDMEA QLMDCQNMLV 6060 EIEQKVVALS ELSVHNENLL LEGKAHTKDE AEQLAGKLRR LKGSLLELQR ALHDKQLNMQ 6120 GTAQEKEESD VDLTATQSPG VQEWLAQART TWTQQRQSSL QQQKELEQEL AEQKSLLRSV 6180 ASRGEEILIQ HSAAETSGDA GEKPDVLSQE LGMEGEKSSA EDQMRMKWES LHQEFSTKQK 6240 LLQNVLEQEQ EQVLYSRPNR LLSGVPLYKG DVPTQDKSAV TSLLDGLNQA FEEVSSQSGG 6300 AKRQSIHLEQ KLYDGVSATS TWLDDVEERL FVATALLPEE TETCLFNQEI LAKDIKEMSE 6360 EMDKNKNLFS QAFPENGDNR DVIEDTLGCL LGRLSLLDSV VNQRCHQMKE RLQQILNFQN 6420 DLKVLFTSLA DNKYIILQKL ANVFEQPVAE QIEAIQQAED GLKEFDAGII ELKRRGDKLQ 6480 VEQPSMQELS KLQDMYDELM MIIGSRRSGL NQNLTLKSQY ERALQDLADL LETGQEKMAG 6540 DQKIIVSSKE EIQQLLDKHK EYFQGLESHM ILTETLFRKI ISFAVQKETQ FHTELMAQAS 6600 AVLKRAHKRG VELEYILETW SHLDEDQQEL SRQLEVVESS IPSVGLVEEN EDRLIDRITL 6660 YQHLKSSLNE YQPKLYQVLD DGKRLLISIS CSDLESQLNQ LGECWLSNTN KMSKELHRLE 6720 TILKHWTRYQ SESADLIHWL QSAKDRLEFW TQQSVTVPQE LEMVRDHLNA FLEFSKEVDA 6780 QSSLKSSVLS TGNQLLRLKK VDTATLRSEL SRIDSQWTDL LTNIPAVQEK LHQLQMDKLP 6840 SRHAISEVMS WISLMENVIQ KDEDNIKNSI GYKAIHEYLQ KYKGFKIDIN CKQLTVDFVN 6900 QSVLQISSQD VESKRSDKTD FAEQLGAMNK SWQILQGLVT EKIQLLEGLL ESWSEYENNV 6960 QCLKTWFETQ EKRLKQQHRI GDQASVQNAL KDCQDLEDLI KAKEKEVEKI EQNGLALIQN 7020 KKEDVSSIVM STLRELGQTW ANLDHMVGQL KILLKSVLDQ WSSHKVAFDK INSYLMEARY 7080 SLSRFRLLTG SLEAVQVQVD NLQNLQDDLE KQERSLQKFG SITNQLLKEC HPPVTETLTN 7140 TLKEVNMRWN NLLEEIAEQL QSSKALLQLW QRYKDYSKQC ASTVQQQEDR TNELLKAATN 7200 KDIADDEVAT WIQDCNDLLK GLGTVKDSLF FLHELGEQLK QQVDASAASA IQSDQLSLSQ 7260 HLCALEQALC KQQTSLQAGV LDYETFAKSL EALEAWIVEA EEILQGQDPS HSSDLSTIQE 7320 RMEELKGQML KFSSMAPDLD RLNELGYRLP LNDKEIKRMQ NLNRHWSLIS SQTTERFSKL 7380 QSFLLQHQTF LEKCETWMEF LVQTEQKLAV EISGNYQHLL EQQRAHELFQ AEMFSRQQIL 7440 HSIIIDGQRL LEQGQVDDRD EFNLKLTLLS NQWQGVIRRA QQRRGIIDSQ IRQWQRYREM 7500 AEKLRKWLVE VSYLPMSGLG SVPIPLQQAR TLFDEVQFKE KVFLRQQGSY ILTVEAGKQL 7560 LLSADSGAEA ALQAELAEIQ EKWKSASMRL EEQKKKLAFL LKDWEKCEKG IADSLEKLRT 7620 FKKKLSQSLP DHHEELHAEQ MRCKELENAV GSWTDDLTQL SLLKDTLSAY ISADDISILN 7680 ERVELLQRQW EELCHQLSLR RQQIGERLNE WAVFSEKNKE LCEWLTQMES KVSQNGDILI 7740 EEMIEKLKKD YQEEIAIAQE NKIQLQQMGE RLAKASHESK ASEIEYKLGK VNDRWQHLLD 7800 LIAARVKKLK ETLVAVQQLD KNMSSLRTWL AHIESELAKP IVYDSCNSEE IQRKLNEQQE 7860 LQRDIEKHST GVASVLNLCE VLLHDCDACA TDAECDSIQQ ATRNLDRRWR NICAMSMERR 7920 LKIEETWRLW QKFLDDYSRF EDWLKSSERT AAFPSSSGVI YTVAKEELKK FEAFQRQVHE 7980 CLTQLELINK QYRRLARENR TDSACSLKQM VHEGNQRWDN LQKRVTSILR RLKHFIGQRE 8040 EFETARDSIL VWLTEMDLQL TNIEHFSECD VQAKIKQLKA FQQEISLNHN KIEQIIAQGE 8100 QLIEKSEPLD AAIIEEELDE LRRYCQEVFG RVERYHKKLI RLPLPDDEHD LSDRELELED 8160 SAALSDLHWH DRSADSLLSP QPSSNLSLSL AQPLRSERSG RDTPASVDSI PLEWDHDYDL 8220 SRDLESAMSR ALPSEDEEGQ DDKDFYLRGA VGLSDVMIPE SPEAYVKLTE NAIKNTSGDH 8280 SALESQIRQL GKALDDSRFQ IQQTENIIRS KTPTGPELDT SYKGYMKLLG ECSSSIDSVK 8340 RLEHKLKEEE ESLPGFVNLH STETQTAGVI DRWELLQAQA LSKELRMKQN LQKWQQFNSD 8400 LNSIWAWLGD TEEELEQLQR LELSTDIQTI ELQIKKLKEL QKAVDHRKAI ILSINLCSPE 8460 FTQADSKESR DLQDRLSQMN GRWDRVCSLL EEWRGLLQDA LMQCQGFHEM SHGLLLMLEN 8520 IDRRKNEIVP IDSNLDAEIL QDHHKQLMQI KHELLESQLR VASLQDMSCQ LLVNAEGTDC 8580 LEAKEKVHVI GNRLKLLLKE VSRHIKELEK LLDVSSSQQD LSSWSSADEL DTSGSVSPTS 8640 GRSTPNRQKT PRGKCSLSQP GPSVSSPHSR STKGGSDSSL SEPGPGRSGR GFLFRVLRAA 8700 LPLQLLLLLL IGLACLVPMS EEDYSCALSN NFARSFHPML RYTNGPPPL 8749 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |