CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037392
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Nesprin-1 
Protein Synonyms/Alias
  
Gene Name
 SYNE1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
3804EKGLHLAKEFSDKCKubiquitination[1]
5051ELMNDTEKKLSEFSLubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661
Functional Description
  
Sequence Annotation
  
Keyword
 Actin-binding; Complete proteome; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 8749 AA 
Protein Sequence
MATSRGASRC PRDIANVMQR LQDEQEIVQK RTFTKWINSH LAKRKPPMVV DDLFEDMKDG 60
VKLLALLEVL SGQKLPCEQG RRMKRIHAVA NIGTALKFLE GRKSMHRGSP IKLVNINSTD 120
IADGRPSIVL GLMWTIILYF QIEELTSNLP QLQSLSSSAS SVDSIVSSET PSPPSKRKVT 180
TKIQGNAKKA LLKWVQYTAG KQTGIEVKDF GKSWRSGVAF HSVIHAIRPE LVDLETVKGR 240
SNRENLEDAF TIAETELGIP RLLDPEDVDV DKPDEKSIMT YVAQFLKHYP DIHNASTDGQ 300
EDDEILPGFP SFANSVQNFK REDRVIFKEM KVWIEQFERD LTRAQMVESN LQDKYQSFKH 360
FRVQYEMKRK QIEHLIQPLH RDGKLSLDQA LVKQSWDRVT SRLFDWHIQL DKSLPAPLGT 420
IGAWLYRAEV ALREEITVQQ VHEETANTIQ RKLEQHKDLL QNTDAHKRAF HEIYRTRSVN 480
GIPVPPDQLE DMAERFHFVS STSELHLMKM EFLELKYRLL SLLVLAESKL KSWIIKYGRR 540
ESVEQLLQNY VSFIENSKFF EQYEVTYQIL KQTAEMYVKA DGSVEEAENV MKFMNETTAQ 600
WRNLSVEVRS VRSMLEEVIS NWDRYGNTVA SLQAWLEDAE KMLNQSENAK KDFFRNLPHW 660
IQQHTAMNDA GNFLIETCDE MVSRDLKQQL LLLNGRWREL FMEVKQYAQA DEMDRMKKEY 720
TDCVVTLSAF ATEAHKKLSE PLEVSFMNVK LLIQDLEDIE QRVPVMDAQY KIITKTAHLI 780
TKESPQEEGK EMFATMSKLK EQLTKVKECY SPLLYESQQL LIPLEELEKQ MTSFYDSLGK 840
INEIITVLER EAQSSALFKQ KHQELLACQE NCKKTLTLIE KGSQSVQKFV TLSNVLKHFD 900
QTRLQRQIAD IHVAFQSMVK KTGDWKKHVE TNSRLMKKFE ESRAELEKVL RIAQEGLEEK 960
GDPEELLRRH TEFFSQLDQR VLNAFLKACD ELTDILPEQE QQGLQEAVRK LHKQWKDLQG 1020
EAPYHLLHLK IDVEKNRFLA SVEECRTELD RETKLMPQEG SEKIIKEHRV FFSDKGPHHL 1080
CEKRLQLIEE LCVKLPVRDP VRDTPGTCHV TLKELRAAID STYRKLMEDP DKWKDYTSRF 1140
SEFSSWISTN ETQLKGIKGE AIDTANHGEV KRAVEEIRNG VTKRGETLSW LKSRLKVLTE 1200
VSSENEAQKQ GDELAKLSSS FKALVTLLSE VEKMLSNFGD CVQYKEIVKN SLEELISGSK 1260
EVQEQAEKIL DTENLFEAQQ LLLHHQQKTK RISAKKRDVQ QQIAQAQQGE GGLPDRGHEE 1320
LRKLESTLDG LERSRERQER RIQVTLRKWE RFETNKETVV RYLFQTGSSH ERFLSFSSLE 1380
SLSSELEQTK EFSKRTESIA VQAENLVKEA SEIPLGPQNK QLLQQQAKSI KEQVKKLEDT 1440
LEEDIKTMEM VKTKWDHFGS NFETLSVWIT EKEKELNALE TSSSAMDMQI SQIKVTIQEI 1500
ESKLSSIVGL EEEAQSFAQF VTTGESARIK AKLTQIRRYG EELREHAQCL EGTILGHLSQ 1560
QQKFEENLRK IQQSVSEFED KLAVPIKICS SATETYKVLQ EHMDLCQALE SLSSAITAFS 1620
ASARKVVNRD SCVQEAAALQ QQYEDILRRA KERQTALENL LAHWQRLEKE LSSFLTWLER 1680
GEAKASSPEM DISADRVKVE GELQLIQASS RKFVSQASFY SKLLQLKESL FSVASKDDVK 1740
MMKLHLEQLD ERWRDLPQII NKRINFLQSV VAEHQQFDEL LLSFSVWIKL FLSELQTTSE 1800
ISIMDHQVAL TRHKDHAAEV ESKKGELQSL QGHLAKLGSL GRAEDLHLLQ GKAEDCFQLF 1860
EEASQVVERR QLALSHLAEF LQSHASLSGI LRQLRQTVEA TNSMNKNESD LIEKDLNDAL 1920
QNAKALESAA VSLDGILSKA QYHLKIGSSE QRTSCRATAD QLCGEVERIQ NLLGTKQSEA 1980
DALAVLKKAF QDQKEELLKS IEDIEERTDK ERLKEPTRQA LQQRLRVFNQ LEDELNSHEH 2040
ELCWLKDKAK QIAQKDVAFA PEVDREINRL EVTWDDTKRL IHENQGQCCG LIDLMREYQN 2100
LKSAVSKVLE NASSVIVTRT TIKDQEDLKW AFSKHETAKN KMNYKQKDLD NFTSKGKHLL 2160
SELKKIHSSD FSLVKTDMES TVDKWLDVSE KLEENMDRLR VSLSIWDDVL STRDEIEGWS 2220
NNCVPQMAEN ISNLDNHLRA EELLKEFESE VKNKALRLEE LHSKVNDLKE LTKNLETPPD 2280
LQFIEADLMQ KLEHAKEITE VAKGTLKDFT AQSTQVEKFI NDITTWFTKV EESLMNCAQN 2340
ETCEALKKVK DIQKELQSQQ SNISSTQENL NSLCRKYHSA ELESLGRAMT GLIKKHEAVS 2400
QLCSKTQASL QESLEKHFSE SMQEFQEWFL GAKAAAKESS DRTGDSKVLE AKLHDLQNIL 2460
DSVSDGQSKL DAVTQEGQTL YAHLSKQIVS SIQEQITKAN EEFQAFLKQC LKDKQALQDC 2520
ASELGSFEDQ HRKLNLWIHE MEERFNTENL GESKQHIPEK KNEVHKVEMF LGELLAARES 2580
LDKLSQRGQL LSEEGHGAGQ EGRLCSQLLT SHQNLLRMTK EKLRSCQVAL QEHEALEEAL 2640
QSMWFWVKAI QDRLACAEST LGSKDTLEKR LSQIQDILLM KGEGEVKLNM AIGKGEQALR 2700
SSNKEGQRVI QTQLETLKEV WADIMSSSVH AQSTLESVIS QWNDYVERKN QLEQWMESVD 2760
QKIEHPLQPQ PGLKEKFVLL DHLQSILSEA EDHTRALHRL IAKSRELYEK TEDESFKDTA 2820
QEELKTQFND IMTVAKEKMR KVEEIVKDHL MYLDAVHEFT DWLHSAKEEL HRWSDMSGDS 2880
SATQKKLSKI KELIDSREIG ASRLSRVESL APEVKQNTTA SGCELMHTEM QALRADWKQW 2940
EDSVFQTQSC LENLVSQMAL SEQEFSGQVA QLEQALEQFS ALLKTWAQQL TLLEGKNTDE 3000
EIVECWHKGQ EILDALQKAE PRTEDLKSQL NELCRFSRDL STYSGKVSGL IKEYNCLCLQ 3060
ASKGCQNKEQ ILQQRFRKAF RDFQQWLVNA KITTAKCFDI PQNISEVSTS LQKIQEFLSE 3120
SENGQHKLNM MLSKGELLST LLTKEKAKGI QAKVTAAKED WKNFHSNLHQ KESALENLKI 3180
QMKDFEVSAE PIQDWLSKTE KMVHESSNRL YDLPAKRREQ QKLQSVLEEI HCYEPQLNRL 3240
KEKAQQLWEG QAASKSFRHR VSQLSSQYLA LSNLTKEKVS RLDRIVAEHN QFSLGIKELQ 3300
DWMTDAIHML DSYCHPTSDK SVLDSRTLKL EALLSVKQEK EIQMKMIVTR GESVLQNTSP 3360
EGIPTIQQQL QSVKDMWASL LSAGIRCKSQ LEGALSKWTS YQDGVRQFSG WMDSMEANLN 3420
ESERQHAELR DKTTMLGKAK LLNEEVLSYS SLLETIEVKG AGMTEHYVTQ LELQDLQERY 3480
RAIQERAKEA VTKSEKLVRL HQEYQRDLKA FEVWLGQEQE KLDQYSVLEG DAHTHETTLR 3540
DLQELQVHCA EGQALLNSVL HTREDVIPSG IPQAEDRALE SLRQDWQAYQ HRLSETRTQF 3600
NNVVNKLRLM EQKFQQVDEW LKTAEEKKWH EEVTAYRDEV EEVGARAQEI LDESHVNSRM 3660
GCQATQLTSR YQALLLQVLE QIKFLEEEIQ SLEESESSLS SYSDWYGSTH KNFKNVATKI 3720
DKVDTVMMGK KLKTLEVLLK DMEKGHSLLK SAREKGERAV KYLEEGEAER LRKEIHDHME 3780
QLKELTSTVR KEHMTLEKGL HLAKEFSDKC KALTQWIAEY QEILHVPEEP KMELYEKKAQ 3840
LSKYKSLQQT VLSHEPSVKS VREKGEALLE LVQDVTLKDK IDQLQSDYQD LCSIGKAMME 3900
EIAGFEDRLN NLQMKGDTLI GQCADHLQAK LKQNVHAHLQ GTKDSYSAIC STAQRMYQSL 3960
EHELQKHVSR QDTLQQCQAW LSAVQPDLEP SPQPPLSRAE AIKQVKHFRA LQEQARTYLD 4020
LLCSMCDLSN ASVKTTAKDI QQTEQTIEQK LVQAQNLTQG WEEIKHLKSE LWIYLQDADQ 4080
QLQNMKRRHS ELELNIAQNM VSQVKDFVKK LQSKQASVNT IIEKVNKLTK KEESPEHKEI 4140
NHLNDQWLDL CRQSNNLCLQ REEDLQRTRD YHDCMNVVEV FLEKFTTEWD NLARSDAEST 4200
AVHLEALKKL ALALQERKYA IEDLKDQKQK MIEHLNLDDK ELVKEQTSHL EQRWFQLEDL 4260
IKRKIQVSVT NLEELNVVQS RFQELMEWAE EQQPNIAEAL KQSPPPDMAQ NLLMDHLAIC 4320
SELEAKQMLL KSLIKDADRV MADLGLNERQ VIQKALSDAQ SHVNCLSDLV GQRRKYLNKA 4380
LSEKTQFLMA VFQATSQIQQ HERKIMFREH ICLLPDDVSK QVKTCKSAQA SLKTYQNEVT 4440
GLWAQGRELM KEVTEQEKSE VLGKLQELQS VYDSVLQKCS HRLQELEKNL VSRKHFKEDF 4500
DKACHWLKQA DIVTFPEINL MNESSELHTQ LAKYQNILEQ SPEYENLLLT LQRTGQTILP 4560
SLNEVDHSYL SEKLNALPRQ FNVIVALAKD KFYKVQEAIL ARKEYASLIE LTTQSLSELE 4620
AQFLRMSKVP TDLAVEEALS LQDGCRAILD EVAGLGEAVD ELNQKKEGFR STGQPWQPDK 4680
MLHLVTLYHR LKRQTEQRVS LLEDTTSAYQ EHEKMCQQLE RQLKSVKEEQ SKVNEETLPA 4740
EEKLKMYHSL AGSLQDSGIV LKRVTIHLED LAPHLDPLAY EKARHQIQSW QGELKLLTSA 4800
IGETVTECES RMVQSIDFQT EMSRSLDWLR RVKAELSGPV YLDLNLQDIQ EEIRKIQIHQ 4860
EEVQSSLRIM NALSHKEKEK FTKAKELISA DLEHSLAELS ELDGDIQEAL RTRQATLTEI 4920
YSQCQRYYQV FQAANDWLED AQELLQLAGN GLDVESAEEN LKSHMEFFST EDQFHSNLEE 4980
LHSLVATLDP LIKPTGKEDL EQKVASLELR SQRMSRDSGA QVDLLQRCTA QWHDYQKARE 5040
EVIELMNDTE KKLSEFSLLK TSSSHEAEEK LSEHKALVSV VNSFHEKIVA LEEKASQLEK 5100
TGNDASKATL SRSMTTVWQR WTRLRAVAQD QEKILEDAVD EWTGFNNKVK KATEMIDQLQ 5160
DKLPGSSAEK ASKAELLTLL EYHDTFVLEL EQQQSALGML RQQTLSMLQD GAAPTPGEEP 5220
PLMQEITAMQ DRCLNMQEKV KTNGKLVKQE LKDREMVETQ INSVKCWVQE TKEYLGNPTI 5280
EIDAQLEELQ ILLTEATNHR QNIEKMAEEQ KEKYLGLYTI LPSELSLQLA EVALDLKIRD 5340
QIQDKIKEVE QSKATSQELS RQIQKLAKDL TTILTKLKAK TDNVVQAKTD QKVLGEELDG 5400
CNSKLMELDA AVQKFLEQNG QLGKPLAKKI GKLTELHQQT IRQAENRLSK LNQAASHLEE 5460
YNEMLELILK WIEKAKVLAH GTIAWNSASQ LREQYILHQT LLEESKEIDS ELEAMTEKLQ 5520
YLTSVYCTEK MSQQVAELGR ETEELRQMIK IRLQNLQDAA KDMKKFEAEL KKLQAALEQA 5580
QATLTSPEVG RLSLKEQLSH RQHLLSEMES LKPKVQAVQL CQSALRIPED VVASLPLCHA 5640
ALRLQEEASR LQHTAIQQCN IMQAAVVQYE QYEQEMKHLQ QLIEGAHREI EDKPVATSNI 5700
QELQAQISRH EELAQKIKGY QEQIASLNSK CKMLTMKAKH ATMLLTVTEV EGLAEGTEDL 5760
DGELLPTPSA HPSVVMMTAG RCHTLLSPVT EESGEEGTNS EISSPPACRS PSPVANTDAS 5820
VNQDIAYYQA LSAERLQTDA AKIHPSTSAS QEFYEPGLEP SATAKLGDLQ RSWETLKNVI 5880
SEKQRTLYEA LERQQKYQDS LQSISTKMEA IELKLSESPE PGRSPESQMA EHQALMDEIL 5940
MLQDEINELQ SSLAEELVSE SCEADPAEQL ALQSTLTVLA ERMSTIRMKA SGKRQLLEEK 6000
LNDQLEEQRQ EQALQRYRCE ADELDSWLLS TKATLDTALS PPKEPMDMEA QLMDCQNMLV 6060
EIEQKVVALS ELSVHNENLL LEGKAHTKDE AEQLAGKLRR LKGSLLELQR ALHDKQLNMQ 6120
GTAQEKEESD VDLTATQSPG VQEWLAQART TWTQQRQSSL QQQKELEQEL AEQKSLLRSV 6180
ASRGEEILIQ HSAAETSGDA GEKPDVLSQE LGMEGEKSSA EDQMRMKWES LHQEFSTKQK 6240
LLQNVLEQEQ EQVLYSRPNR LLSGVPLYKG DVPTQDKSAV TSLLDGLNQA FEEVSSQSGG 6300
AKRQSIHLEQ KLYDGVSATS TWLDDVEERL FVATALLPEE TETCLFNQEI LAKDIKEMSE 6360
EMDKNKNLFS QAFPENGDNR DVIEDTLGCL LGRLSLLDSV VNQRCHQMKE RLQQILNFQN 6420
DLKVLFTSLA DNKYIILQKL ANVFEQPVAE QIEAIQQAED GLKEFDAGII ELKRRGDKLQ 6480
VEQPSMQELS KLQDMYDELM MIIGSRRSGL NQNLTLKSQY ERALQDLADL LETGQEKMAG 6540
DQKIIVSSKE EIQQLLDKHK EYFQGLESHM ILTETLFRKI ISFAVQKETQ FHTELMAQAS 6600
AVLKRAHKRG VELEYILETW SHLDEDQQEL SRQLEVVESS IPSVGLVEEN EDRLIDRITL 6660
YQHLKSSLNE YQPKLYQVLD DGKRLLISIS CSDLESQLNQ LGECWLSNTN KMSKELHRLE 6720
TILKHWTRYQ SESADLIHWL QSAKDRLEFW TQQSVTVPQE LEMVRDHLNA FLEFSKEVDA 6780
QSSLKSSVLS TGNQLLRLKK VDTATLRSEL SRIDSQWTDL LTNIPAVQEK LHQLQMDKLP 6840
SRHAISEVMS WISLMENVIQ KDEDNIKNSI GYKAIHEYLQ KYKGFKIDIN CKQLTVDFVN 6900
QSVLQISSQD VESKRSDKTD FAEQLGAMNK SWQILQGLVT EKIQLLEGLL ESWSEYENNV 6960
QCLKTWFETQ EKRLKQQHRI GDQASVQNAL KDCQDLEDLI KAKEKEVEKI EQNGLALIQN 7020
KKEDVSSIVM STLRELGQTW ANLDHMVGQL KILLKSVLDQ WSSHKVAFDK INSYLMEARY 7080
SLSRFRLLTG SLEAVQVQVD NLQNLQDDLE KQERSLQKFG SITNQLLKEC HPPVTETLTN 7140
TLKEVNMRWN NLLEEIAEQL QSSKALLQLW QRYKDYSKQC ASTVQQQEDR TNELLKAATN 7200
KDIADDEVAT WIQDCNDLLK GLGTVKDSLF FLHELGEQLK QQVDASAASA IQSDQLSLSQ 7260
HLCALEQALC KQQTSLQAGV LDYETFAKSL EALEAWIVEA EEILQGQDPS HSSDLSTIQE 7320
RMEELKGQML KFSSMAPDLD RLNELGYRLP LNDKEIKRMQ NLNRHWSLIS SQTTERFSKL 7380
QSFLLQHQTF LEKCETWMEF LVQTEQKLAV EISGNYQHLL EQQRAHELFQ AEMFSRQQIL 7440
HSIIIDGQRL LEQGQVDDRD EFNLKLTLLS NQWQGVIRRA QQRRGIIDSQ IRQWQRYREM 7500
AEKLRKWLVE VSYLPMSGLG SVPIPLQQAR TLFDEVQFKE KVFLRQQGSY ILTVEAGKQL 7560
LLSADSGAEA ALQAELAEIQ EKWKSASMRL EEQKKKLAFL LKDWEKCEKG IADSLEKLRT 7620
FKKKLSQSLP DHHEELHAEQ MRCKELENAV GSWTDDLTQL SLLKDTLSAY ISADDISILN 7680
ERVELLQRQW EELCHQLSLR RQQIGERLNE WAVFSEKNKE LCEWLTQMES KVSQNGDILI 7740
EEMIEKLKKD YQEEIAIAQE NKIQLQQMGE RLAKASHESK ASEIEYKLGK VNDRWQHLLD 7800
LIAARVKKLK ETLVAVQQLD KNMSSLRTWL AHIESELAKP IVYDSCNSEE IQRKLNEQQE 7860
LQRDIEKHST GVASVLNLCE VLLHDCDACA TDAECDSIQQ ATRNLDRRWR NICAMSMERR 7920
LKIEETWRLW QKFLDDYSRF EDWLKSSERT AAFPSSSGVI YTVAKEELKK FEAFQRQVHE 7980
CLTQLELINK QYRRLARENR TDSACSLKQM VHEGNQRWDN LQKRVTSILR RLKHFIGQRE 8040
EFETARDSIL VWLTEMDLQL TNIEHFSECD VQAKIKQLKA FQQEISLNHN KIEQIIAQGE 8100
QLIEKSEPLD AAIIEEELDE LRRYCQEVFG RVERYHKKLI RLPLPDDEHD LSDRELELED 8160
SAALSDLHWH DRSADSLLSP QPSSNLSLSL AQPLRSERSG RDTPASVDSI PLEWDHDYDL 8220
SRDLESAMSR ALPSEDEEGQ DDKDFYLRGA VGLSDVMIPE SPEAYVKLTE NAIKNTSGDH 8280
SALESQIRQL GKALDDSRFQ IQQTENIIRS KTPTGPELDT SYKGYMKLLG ECSSSIDSVK 8340
RLEHKLKEEE ESLPGFVNLH STETQTAGVI DRWELLQAQA LSKELRMKQN LQKWQQFNSD 8400
LNSIWAWLGD TEEELEQLQR LELSTDIQTI ELQIKKLKEL QKAVDHRKAI ILSINLCSPE 8460
FTQADSKESR DLQDRLSQMN GRWDRVCSLL EEWRGLLQDA LMQCQGFHEM SHGLLLMLEN 8520
IDRRKNEIVP IDSNLDAEIL QDHHKQLMQI KHELLESQLR VASLQDMSCQ LLVNAEGTDC 8580
LEAKEKVHVI GNRLKLLLKE VSRHIKELEK LLDVSSSQQD LSSWSSADEL DTSGSVSPTS 8640
GRSTPNRQKT PRGKCSLSQP GPSVSSPHSR STKGGSDSSL SEPGPGRSGR GFLFRVLRAA 8700
LPLQLLLLLL IGLACLVPMS EEDYSCALSN NFARSFHPML RYTNGPPPL 8749 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0016021; C:integral to membrane; IEA:InterPro.
 GO:0031965; C:nuclear membrane; IDA:HPA. 
Interpro
 IPR001589; Actinin_actin-bd_CS.
 IPR001715; CH-domain.
 IPR012315; KASH.
 IPR018159; Spectrin/alpha-actinin.
 IPR002017; Spectrin_repeat. 
Pfam
 PF00307; CH
 PF10541; KASH
 PF00435; Spectrin 
SMART
 SM00033; CH
 SM00150; SPEC 
PROSITE
 PS00019; ACTININ_1
 PS00020; ACTININ_2
 PS50021; CH
 PS51049; KASH 
PRINTS