CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-043355
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Beta-hexosaminidase 
Protein Synonyms/Alias
  
Gene Name
 HEXA 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
235TFPELMRKGSYNPVTubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
 ACT_SITE 334 334 Proton donor (By similarity).
 DISULFID 288 339 By similarity.
 DISULFID 516 533 By similarity.  
Keyword
 Complete proteome; Disulfide bond; Glycosidase; Hydrolase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 540 AA 
Protein Sequence
MTSSRLWFSL LLAAAFAGRA TALWPWPQNF QTSDQRYVLY PNNFQFQYDV SSAAQPGCSV 60
LDEAFQRYRD LLFGSGSWPR PYLTGWPHQA YPVFLGKRHT LEKNVLVVSV VTPGCNQLPT 120
LESVENYTLT INDDQCLLLS ETVWGALRGL ETFSQLVWKS AEGTFFINKT EIEDFPRFPH 180
RGLLLDTSRH YLPLSSILDT LDVMAYNKLN VFHWHLVDDP SFPYESFTFP ELMRKGSYNP 240
VTHIYTAQDV KEVIEYARLR GIRVLAEFDT PGHTLSWGPG IPGLLTPCYS GSEPSGTFGP 300
VNPSLNNTYE FMSTFFLEVS SVFPDFYLHL GGDEVDFTCW KSNPEIQDFM RKKGFGEDFK 360
QLESFYIQTL LDIVSSYGKG YVVWQEVFDN KVKIQPDTII QVWREDIPVN YMKELELVTK 420
AGFRALLSAP WYLNRISYGP DWKDFYIVEP LAFEGTPEQK ALVIGGEACM WGEYVDNTNL 480
VPRLWPRAGA VAERLWSNKL TSDLTFAYER LSHFRCELLR RGVQAQPLNV GFCEQEFEQT 540 
Gene Ontology
 GO:0004563; F:beta-N-acetylhexosaminidase activity; IEA:EC.
 GO:0005975; P:carbohydrate metabolic process; IEA:InterPro. 
Interpro
 IPR025705; Beta_hexosaminidase_sua/sub.
 IPR015883; Glyco_hydro_20_cat-core.
 IPR015882; Glyco_hydro_20b.
 IPR013781; Glyco_hydro_catalytic_dom.
 IPR017853; Glycoside_hydrolase_SF. 
Pfam
 PF00728; Glyco_hydro_20
 PF02838; Glyco_hydro_20b 
SMART
  
PROSITE
  
PRINTS
 PR00738; GLHYDRLASE20.