CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-012429
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Pentatricopeptide repeat domain-containing protein 3, mitochondrial 
Protein Synonyms/Alias
  
Gene Name
 Ptcd3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
311LNEKFEEKWNDILDLacetylation[1]
328HMVAQKVKPNLQTFNacetylation[2]
328HMVAQKVKPNLQTFNsuccinylation[2]
Reference
 [1] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 
Functional Description
 Mitochondrial RNA-binding protein that has a role in mitochondrial translation (By similarity). 
Sequence Annotation
 REPEAT 150 184 PPR 1.
 REPEAT 185 220 PPR 2.
 REPEAT 254 288 PPR 3.
 REPEAT 289 329 PPR 4.
 REPEAT 330 366 PPR 5.
 REPEAT 367 407 PPR 6.
 REPEAT 412 446 PPR 7.
 REPEAT 454 488 PPR 8.
 REPEAT 489 523 PPR 9.
 REPEAT 572 606 PPR 10.
 MOD_RES 127 127 N6-acetyllysine (By similarity).  
Keyword
 Acetylation; Complete proteome; Mitochondrion; Reference proteome; Repeat; RNA-binding; rRNA-binding; Transit peptide; Translation regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 685 AA 
Protein Sequence
MAAAAVAARR LSFRSGLVLL QTTRGTGVCE PKVCCRFYAG TESLPKVEGS DITGIEEIVI 60
PKKKTWDKVA VLQALASTVN RDPTAAPYVF HDDPYLIPTS ALESRSFLLA KKSGETAAKF 120
IINSYPKYFQ KDIAEPHIPC LMPEYFEPQI EDVSEAALEE RIRLRKVRAS VDMFDQLLQA 180
GTTVSLETTN SLLDLLCYYG DQEPPADYPF QQTEHLENLE EAAEENNQTS KMESGPWKAQ 240
NNAERIFALM PEKNARSYCT MIRGMVKHRA YAQALNVYTE LLNNRLSADV YTFNALIEAK 300
TFILNEKFEE KWNDILDLLK HMVAQKVKPN LQTFNTILKG LRKCYSLGRI PALQILREMK 360
HIGIEPSLAT YHHIIHLFYP RDLSAIKMPS LIIYDIMNEL EGRTFSPQDL DDGRFFQLAM 420
SVCSSLRDLE LAYQVHRLLN TGDNRKLVGH DPLRKVYYSK FFSLICSLEQ IDVTLKWYKD 480
LIPSVFLPHY QIFIGLLQAL DVANRLELVP QIWKDSKEYS HTFRDALREE VLMLMARDKH 540
PPELQVAFAD CAADIKSTYE DQSARQPAFD WPANPLQYIA VLFLRGGRSQ EAWKMLELFK 600
KHKKIPRNEL LEEFMDTAKA SGSTALAIEV VKLASAFSLP IGESLAQRVV MDFTVDPEQK 660
EALGNLTELN SSDGESSSDS DSDDK 685 
Gene Ontology
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0043024; F:ribosomal small subunit binding; ISS:UniProtKB.
 GO:0019843; F:rRNA binding; ISS:UniProtKB.
 GO:0032543; P:mitochondrial translation; ISS:UniProtKB.
 GO:0006417; P:regulation of translation; IEA:UniProtKB-KW. 
Interpro
 IPR002885; Pentatricopeptide_repeat. 
Pfam
 PF13041; PPR_2
 PF13812; PPR_3 
SMART
  
PROSITE
 PS51375; PPR 
PRINTS