CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037961
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Elongation factor 1-delta 
Protein Synonyms/Alias
  
Gene Name
 EEF1D 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
426TNFLAHEKIWFDKFKubiquitination[1, 2]
431HEKIWFDKFKYDDAEubiquitination[1]
475RARENIQKSLAGSSGubiquitination[1, 2]
523ELQQAISKLEARLNVubiquitination[1]
533ARLNVLEKSSPGHRAubiquitination[1, 2]
648GLVWGASKLVPVGYGubiquitination[1, 2]
658PVGYGIRKLQIQCVVubiquitination[1]
Reference
 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Elongation factor; Protein biosynthesis; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 697 AA 
Protein Sequence
MEAPLGSILS PCPGRAATGR AGTGRVGTGL RPPAVLQLCP LLAFYRCVRK MRSGKASCTL 60
ETVWEDKHKY EEAERRFYEH EATQAAASAQ QLPAEGPAMN GPGQDDPEDA DEAEAPDGGS 120
RRDPRKSQDS RKPLQKKRKR SPKSGLGPAD LALLGLSAER VWLDKSLFDQ AESSYRQKLA 180
DVAAQAAWPP ALAPWGLCTH GNQVACHHVT WGIWVNKSSF DQAERAFVEW SQALLLAPDG 240
SRRQGTPNTG QQVAVPDLAH QPSPPVNGQP PLGSLQALVR EVWLEKPRYD AAERGFYEAL 300
FDGHPPGKVR LQERAGLAEG ARRGRRDRRG RNILGNKRAG LRRADGEAPS ALPYCYFLQK 360
DAEAPWLSKP AYDSAECRHH AAEALRVAWC LEAASLSHRP GPRSGLSVSS LRPNRKMATN 420
FLAHEKIWFD KFKYDDAERR FYEQMNGPVA GASRQENGAS VILRDIARAR ENIQKSLAGS 480
SGPGASSGTS GDHGELVVRI ASLEVENQSL RGVVQELQQA ISKLEARLNV LEKSSPGHRA 540
TAPQTQHVSP MRQVEPPAKK PATPAEDDED DDIDLFGSDN EEEDKEAAQL REERLRQYAE 600
KKAKKPALVA KSSILLDVKP WDDETDMAQL EACVRSIQLD GLVWGASKLV PVGYGIRKLQ 660
IQCVVEDDKV GTDLLEEEIT KFEEHVQSVD IAAFNKI 697 
Gene Ontology
 GO:0005853; C:eukaryotic translation elongation factor 1 complex; IEA:InterPro.
 GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW. 
Interpro
 IPR018940; EF-1_beta_acid_region_euk.
 IPR014717; Transl_elong_EF1B/ribosomal_S6.
 IPR001326; Transl_elong_EF1B_B/D_CS.
 IPR014038; Transl_elong_fac_EF1B_bsu/dsu. 
Pfam
 PF10587; EF-1_beta_acid
 PF00736; EF1_GNE 
SMART
 SM00888; EF1_GNE 
PROSITE
 PS00824; EF1BD_1
 PS00825; EF1BD_2 
PRINTS