Tag | Content |
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CPLM ID | CPLM-004908 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Myelin-associated glycoprotein |
Protein Synonyms/Alias | Siglec-4a |
Gene Name | Mag |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
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570 | RISGAPDKYESREVS | ubiquitination | [1] |
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Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Adhesion molecule in postnatal neural development that mediates sialic-acid dependent cell-cell interactions between neuronal and myelinating cells. Preferentially binds to alpha-2,3- linked sialic acid. Isoform L-MAG is critical for the formation of myelin in the CNS, whereas isoform S-MAG is sufficient to maintain the integrity of myelin in PNS. |
Sequence Annotation | DOMAIN 22 120 Ig-like V-type. DOMAIN 139 237 Ig-like C2-type 1. DOMAIN 241 325 Ig-like C2-type 2. DOMAIN 327 412 Ig-like C2-type 3. DOMAIN 413 508 Ig-like C2-type 4. BINDING 118 118 Sialic acid (By similarity). LIPID 531 531 S-palmitoyl cysteine (By similarity). CARBOHYD 99 99 N-linked (GlcNAc...) (Potential). CARBOHYD 223 223 N-linked (GlcNAc...) (Potential). CARBOHYD 246 246 N-linked (GlcNAc...) (Potential). CARBOHYD 315 315 N-linked (GlcNAc...) (Potential). CARBOHYD 332 332 N-linked (GlcNAc...) (Potential). CARBOHYD 406 406 N-linked (GlcNAc...) (Potential). CARBOHYD 450 450 N-linked (GlcNAc...) (Potential). CARBOHYD 454 454 N-linked (GlcNAc...) (Potential). DISULFID 37 165 By similarity. DISULFID 42 100 By similarity. DISULFID 159 217 By similarity. DISULFID 261 305 By similarity. DISULFID 347 392 By similarity. DISULFID 421 430 By similarity. DISULFID 432 488 By similarity. |
Keyword | Alternative splicing; Cell adhesion; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Immunoglobulin domain; Lectin; Lipoprotein; Membrane; Palmitate; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 626 AA |
Protein Sequence | MIFLATLPLF WIMISASRGG HWGAWMPSTI SAFEGTCVSI PCRFDFPDEL RPAVVHGVWY 60 FNSPYPKNYP PVVFKSRTQV VHESFQGRSR LLGDLGLRNC TLLLSTLSPE LGGKYYFRGD 120 LGGYNQYTFS EHSVLDIVNT PNIVVPPEVV AGTEVEVSCM VPDNCPELRP ELSWLGHEGL 180 GEPTVLGRLR EDEGTWVQVS LLHFVPTREA NGHRLGCQAA FPNTTLQFEG YASLDVKYPP 240 VIVEMNSSVE AIEGSHVSLL CGADSNPPPL LTWMRDGMVL REAVAKSLYL DLEEVTPGED 300 GVYACLAENA YGQDNRTVEL SVMYAPWKPT VNGTVVAVEG ETVSILCSTQ SNPDPILTIF 360 KEKQILATVI YESQLQLELP AVTPEDDGEY WCVAENQYGQ RATAFNLSVE FAPIILLESH 420 CAAARDTVQC LCVVKSNPEP SVAFELPSRN VTVNETEREF VYSERSGLLL TSILTIRGQA 480 QAPPRVICTS RNLYGTQSLE LPFQGAHRLM WAKIGPVGAV VAFAILIAIV CYITQTRRKK 540 NVTESSSFSG GDNPHVLYSP EFRISGAPDK YESREVSTRD CH 582 |
Gene Ontology | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0033270; C:paranode region of axon; IDA:BHF-UCL. GO:0043220; C:Schmidt-Lanterman incisure; IDA:BHF-UCL. GO:0007155; P:cell adhesion; IEA:UniProtKB-KW. |
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