UniProt Accession

 SCO1_HUMAN; O75880; B2RDM0 

Genbank Protein ID

 AF026852; AF295386; AF295381; AF295382; AF295383; AF295384; AF295385; AF183424; AK315595; CH471108; BC015504; AF131816 

Genbank Nucleotide ID

 AAD08641.1; AAG23836.1; AAG23836.1; AAG23836.1; AAG23836.1; AAG23836.1; AAG23836.1; AAG09693.1; BAG37967.1; EAW89997.1; AAH15504.1; AAD20051.1 

Protein Name

 Protein SCO1 homolog, mitochondrial 

Protein Synonyms/Alias

  

Gene Name

 SCO1 

Gene Synonyms/Alias

 SCOD1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
89	GDSTRPSKPGPVSWK	ubiquitination	[1, 2]
133	ERQRHIGKPLLGGPF	ubiquitination	[1, 2]
223	YVKEFSPKLVGLTGT	ubiquitination	[3]
283	YFGQNKRKGEIAASI	ubiquitination	[3]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Thought to play a role in cellular copper homeostasis, mitochondrial redox signaling or insertion of copper into the active site of COX. 

Sequence Annotation

 REGION 118 131 Important for dimerization.
 METAL 169 169 Copper.
 METAL 173 173 Copper.
 METAL 260 260 Copper.  

Keyword

 3D-structure; Chaperone; Complete proteome; Copper; Disease mutation; Metal-binding; Mitochondrion; Polymorphism; Reference proteome; Transit peptide. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 301 AA 

Protein Sequence

Gene Ontology

 GO:0005743; C:mitochondrial inner membrane; IEA:InterPro.
 GO:0005739; C:mitochondrion; TAS:ProtInc.
 GO:0005507; F:copper ion binding; IEA:InterPro.
 GO:0006878; P:cellular copper ion homeostasis; IEA:InterPro.
 GO:0006825; P:copper ion transport; IEA:InterPro.
 GO:0006091; P:generation of precursor metabolites and energy; TAS:ProtInc.
 GO:0008535; P:respiratory chain complex IV assembly; TAS:ProtInc. 

Interpro

 IPR003782; SCO1/SenC.
 IPR017276; Synth_of_cyt-c-oxidase_Sco1/2.
 IPR012336; Thioredoxin-like_fold. 

Pfam

 PF02630; SCO1-SenC 

SMART

  

PROSITE

  

PRINTS