UniProt Accession

 KLH36_HUMAN; Q8N4N3; Q8N5G6; Q9H9U6 

Genbank Protein ID

 AK022605; BC032400; BC033821 

Genbank Nucleotide ID

 BAB14124.1; AAH32400.1; AAH33821.1 

Protein Name

 Kelch-like protein 36 

Protein Synonyms/Alias

  

Gene Name

 KLHL36 

Gene Synonyms/Alias

 C16orf44 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
286	AQPVMQTKRTALRTN	ubiquitination	[1, 2]
327	AKSEQWVKETPLPAR	ubiquitination	[1]
420	SVETYSPKTDSWSYV	ubiquitination	[1, 3]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. 

Sequence Annotation

 DOMAIN 46 113 BTB.
 DOMAIN 148 250 BACK.
 REPEAT 296 345 Kelch 1.
 REPEAT 346 397 Kelch 2.
 REPEAT 398 444 Kelch 3.
 REPEAT 446 493 Kelch 4.
 REPEAT 494 546 Kelch 5.
 REPEAT 547 595 Kelch 6.  

Keyword

 Alternative splicing; Complete proteome; Kelch repeat; Reference proteome; Repeat; Ubl conjugation pathway. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 616 AA 

Protein Sequence

Gene Ontology

 GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway. 

Interpro

 IPR011705; BACK.
 IPR000210; BTB/POZ-like.
 IPR011333; BTB/POZ_fold.
 IPR013069; BTB_POZ.
 IPR015916; Gal_Oxidase_b-propeller.
 IPR017096; Kelch-like_gigaxonin.
 IPR006652; Kelch_1. 

Pfam

 PF07707; BACK
 PF00651; BTB
 PF01344; Kelch_1 

SMART

 SM00875; BACK
 SM00225; BTB
 SM00612; Kelch 

PROSITE

 PS50097; BTB 

PRINTS