CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031434
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Nucleoporin NDC1 
Protein Synonyms/Alias
 cDNA FLJ53254, highly similar to Nucleoporin NDC1 
Gene Name
 NDC1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
44LLNGMTQKLILYQEAubiquitination[1]
68SYPVEPKKLNSPEETubiquitination[1, 2, 3]
95PSVPPLVKTSLFSSKubiquitination[3, 4]
102KTSLFSSKLSTPDVVubiquitination[1, 2, 3, 4, 5, 6]
175TSISAEGKTMRQPSVubiquitination[1, 2]
293SLVDTSYKTLRFAFRubiquitination[2, 4]
338LQQFLEFKE******ubiquitination[1]
Reference
 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [5] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [6] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 339 AA 
Protein Sequence
MLLSQYSPSR RQEVFSLSQP GGHPHNWTAI SRECLNLLNG MTQKLILYQE AAATNGRVSS 60
SYPVEPKKLN SPEETAFQTP KSSQMPRPSV PPLVKTSLFS SKLSTPDVVS PFGTPFGSSV 120
MNRMAGIFDV NTCYGSPQSP QLIRRGPRLW TSASDQQMTE FSNPSPSTSI SAEGKTMRQP 180
SVIYSWIQNK REQIKNFLSK RVLIMYFFSK HPEASIQAVF SDAQMHIWAL EGLSHLVAAS 240
FTEDRFGVVQ TTLPAILNTL LTLQEAVDKY FKLPHASSKP PRISGSLVDT SYKTLRFAFR 300
ASLKTAIYRI TTTFGEHLNA VQASAEHQKR LQQFLEFKE 339 
Gene Ontology
  
Interpro
 IPR019049; Nucleoporin_prot_Ndc1/Nup. 
Pfam
 PF09531; Ndc1_Nup 
SMART
  
PROSITE
  
PRINTS