| Tag | Content |
|---|
| CPLM ID | CPLM-017216 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Pleckstrin homology-like domain family B member 2 |
Protein Synonyms/Alias | Protein LL5-beta |
Gene Name | Phldb2 |
Gene Synonyms/Alias | Ll5b |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 655 | RKITELEKNIVGEKT | ubiquitination | [1] | | 686 | QELYSEQKTQLDNCP | ubiquitination | [1] | | 716 | DLLDVESKHFEDLEF | ubiquitination | [1] | | 736 | ESRLDEEKENLTQQL | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane. |
Sequence Annotation | DOMAIN 1139 1242 PH.
MOD_RES 71 71 Phosphoserine (By similarity).
MOD_RES 73 73 Phosphoserine (By similarity).
MOD_RES 156 156 Phosphoserine (By similarity).
MOD_RES 333 333 Phosphoserine (By similarity).
MOD_RES 380 380 Phosphoserine (By similarity).
MOD_RES 383 383 Phosphoserine (By similarity).
MOD_RES 389 389 Phosphoserine.
MOD_RES 411 411 Phosphoserine (By similarity).
MOD_RES 465 465 Phosphoserine.
MOD_RES 486 486 Phosphoserine (By similarity).
MOD_RES 510 510 Phosphoserine.
MOD_RES 546 546 Phosphothreonine (By similarity).
MOD_RES 570 570 Phosphothreonine (By similarity).
MOD_RES 894 894 Phosphothreonine.
MOD_RES 976 976 Phosphoserine. |
Keyword | Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; Direct protein sequencing; Membrane; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1249 AA |
Protein Sequence | MAEDSHMQKQ LEFQNGSLEE GFVVRSLENE PQNMMESLSP RKYSSSLKFK ANGDYSGSYL 60
TLSQPVSAKR SPSPMGTSVR SSPSLAKIQG SKQFCDGIDK NISMKPPISF LSSAASLGGY 120
PLGKADLDHY TGRDSERSTR LSEKPPYSRY SSRNKSHDSV YFLGGLEGRK TSGSLLTMWN 180
GNSLSCTGSS PISRSGAASM PSSPKQVRKM NLQDHSTLQP RLSRHKEPAS ENVSVRTRKY 240
SGSSLSNMGA YSRSLPRLYK ATDNQMSPLS LPPRSSLGNS RRGQLGEKDL PHSLVDSDNY 300
LNFSSLSSGA SPYKTCLSEG NPYVSSALSV PASPRVARKM LLASTSSDDF DRASYSGTSP 360
SHSFISGEPD RVLVARRNFS CGSMELDDSD LESLRQSSET PQPVLRERKS SISSISGRDD 420
LMDYHRRQRE ERLREQEMER LERQRLETIL SLCAEYTKPE GRRLSAGTTV ADVQKINKEL 480
EKLQLSDEES VFEDALVCPD ARYRCHRKGS LQDVDVAGFG NLGHSASFLA PRGSRSDELL 540
GDLTRTPPSS SAAFLKATNE SSYLSILPKT PEDIGEEQRT QELAAMEDAR MVILNNLEEL 600
EQKIKDINDQ MDESSRELDM ECALLDGEQK SETAELMKEK EILDHLNRKI TELEKNIVGE 660
KTKEKVKLDA EREKLERLQE LYSEQKTQLD NCPESMREQL QQQLKRDADL LDVESKHFED 720
LEFQQLEHES RLDEEKENLT QQLLREVAEY QRNIVARKEK ISALKKQASH IVQQAQREQD 780
HFVKEKNNLI MMLQREKENL CNLEKKYSSL TGGKGFPINP NTLKEGYISV NEINESCGNS 840
TNLSPSTQFP ADADAAVTEP ALAVPHRTAV YSGFMSPSTL SPSVTEPSSA TWPEVMTTSV 900
DPFPLNDTPP PLPAKKHRRQ QPQEQQHFRS LEERKKQHKE GLYLSDTLPR KKTTPSLSPH 960
FSSATMGRST TPKAHLPLGQ SNSCGSVLPH SLATMTKDSE SRRMLRGYNH QQMSEGQRQK 1020
PEFYSRTASE SNVYLNSFHY PDRSYKDQAY DTLSLDSSDS METSISACSP DNISSASTSN 1080
IARIEEMERL LKQAHAEKTR LLESREREME AKKRALEEEK RRREILEKRL QEETSQRQKL 1140
IEKEVKIREK QRAQARPLTR YLPVRKEDFD LRSHVETAGH NIDTCFHVSI TEKTCRGYLI 1200
KMGGKIKTWK KRWFVFDRNK RTFSYYADKH EAKLKGVIYF QAIEEVYYDH LKNANKSPNP 1260
LLTFSVKTHD RIYYMVAPSP EAMRIWMDVI VTGAEGYTHF LL 1302 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0045111; C:intermediate filament cytoskeleton; IEA:Compara. GO:0005886; C:plasma membrane; IEA:Compara. GO:0005543; F:phospholipid binding; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |