UniProt Accession

 GSTT1_MOUSE; Q64471; Q91X50 

Genbank Protein ID

 X98055; AC142499; CH466553; BC012254; BC055020 

Genbank Nucleotide ID

 CAA66665.1; EDL31888.1; AAH12254.1; AAH55020.1 

Protein Name

 Glutathione S-transferase theta-1 

Protein Synonyms/Alias

 GST class-theta-1 

Gene Name

 Gstt1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
23	AIYIFAKKNNIPFQM	ubiquitination	[1]
37	MHTVELRKGEHLSDA	ubiquitination	[1]
79	LYLAHKYKVPDHWYP	acetylation	[2]
204	RVEAAVGKDLFREAH	ubiquitination	[1]
216	EAHEVILKVKDCPPA	acetylation	[2]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123] 

Functional Description

 Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Also binds steroids, bilirubin, carcinogens and numerous organic anions. Has dichloromethane dehalogenase activity. 

Sequence Annotation

 DOMAIN 2 82 GST N-terminal.
 DOMAIN 88 222 GST C-terminal.
 REGION 53 54 Glutathione binding (By similarity).
 REGION 66 67 Glutathione binding (By similarity).
 BINDING 40 40 Glutathione (By similarity).  

Keyword

 Complete proteome; Cytoplasm; Nucleus; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 240 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IEA:Compara.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0004602; F:glutathione peroxidase activity; IEA:Compara.
 GO:0004364; F:glutathione transferase activity; IDA:UniProtKB.
 GO:0006749; P:glutathione metabolic process; IDA:UniProtKB.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0014070; P:response to organic cyclic compound; IEA:Compara. 

Interpro

 IPR010987; Glutathione-S-Trfase_C-like.
 IPR004045; Glutathione_S-Trfase_N.
 IPR017933; Glutathione_S_Trfase/Cl_chnl_C.
 IPR004046; GST_C.
 IPR012336; Thioredoxin-like_fold. 

Pfam

 PF00043; GST_C
 PF02798; GST_N 

SMART

  

PROSITE

 PS50405; GST_CTER
 PS50404; GST_NTER 

PRINTS