CPLM-001117

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-001117

UniProt Accession

ASTN2_HUMAN; O75129; A2A2T7; A2A2T9; Q52LQ2; Q5JVX8; Q5JVX9; Q5JVY1; Q5VXG8; Q5VZX6; Q8N6P8; Q8WV47; Q96FL4; Q9UHW6

Genbank Protein ID

AB014534; AL133284; AL133282; AL137024; AL133284; AL133282; AL137024; AL157829; AL354981; AL355608; AL358792; AL392085; AL358792; AL133282; AL133284; AL137024; AL157829; AL354981; AL355608; AL392085; AL157829; AL133282; AL133284; AL137024; AL354981; AL355608; AL358792; AL392085; AL133284; AL133284; AL133282; AL137024; AL133282; AL133284; AL137024; AL157829; AL354981; AL355608; AL358792; AL392085; AL133282; AL133284; AL137024; BC018759; BC029272; BC093835; BC101667; BC146756; AF116574; DA336442

Genbank Nucleotide ID

BAA31609.1; CAM22874.1; CAM22874.1; CAM22874.1; CAI16371.1; CAI16371.1; CAI16371.1; CAI16371.1; CAI16371.1; CAI16371.1; CAI16371.1; CAI16371.1; CAH71966.1; CAH71966.1; CAH71966.1; CAH71966.1; CAH71966.1; CAH71966.1; CAH71966.1; CAH71966.1; CAH72264.1; CAH72264.1; CAH72264.1; CAH72264.1; CAH72264.1; CAH72264.1; CAH72264.1; CAH72264.1; CAI16369.1; CAI16370.1; CAI16370.1; CAI16370.1; CAI39864.1; CAI39864.1; CAI39864.1; CAI39864.1; CAI39864.1; CAI39864.1; CAI39864.1; CAI39864.1; CAM15245.1; CAM15245.1; CAM15245.1; AAH18759.2; AAH29272.1; AAH93835.2; AAI01668.1; AAI46757.1; AAF14357.1

Protein Name

Astrotactin-2

Protein Synonyms/Alias

Gene Name

ASTN2

Gene Synonyms/Alias

KIAA0634

Created Date

July 27, 2013

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Lysine Modification

Position	Peptide	Type	References
1023	LIQDNGTKEAFKSAL	ubiquitination	[1]

Reference

[1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]

Functional Description

Sequence Annotation

DOMAIN 510 550 EGF-like 1.
DOMAIN 651 695 EGF-like 2.
DOMAIN 699 751 EGF-like 3.
DOMAIN 1065 1188 Fibronectin type-III.
CARBOHYD 168 168 N-linked (GlcNAc...) (Potential).
CARBOHYD 783 783 N-linked (GlcNAc...) (Potential).
CARBOHYD 1020 1020 N-linked (GlcNAc...) (Potential).
DISULFID 514 526 By similarity.
DISULFID 522 533 By similarity.
DISULFID 535 549 By similarity.
DISULFID 655 668 By similarity.
DISULFID 662 679 By similarity.
DISULFID 681 694 By similarity.
DISULFID 703 715 By similarity.
DISULFID 711 735 By similarity.
DISULFID 737 750 By similarity.

Keyword

Alternative splicing; Complete proteome; Disulfide bond; EGF-like domain; Glycoprotein; Membrane; Polymorphism; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

1339 AA

Protein Sequence

MAAAGARLSP GPGSGLRGRP RLCFHPGPPP LLPLLLLFLL LLPPPPLLAG ATAAASREPD 60
SPCRLKTVTV STLPALRESD IGWSGARAGA GAGTGAGAAA AAASPGSPGS AGTAAESRLL 120
LFVRNELPGR IAVQDDLDNT ELPFFTLEMS GTAADISLVH WRQQWLENGT LYFHVSMSSS 180
GQLAQATAPT LQEPSEIVEE QMHILHISVM GGLIALLLLL LVFTVALYAQ RRWQKRRRIP 240
QKSASTEATH EIHYIPSVLL GPQARESFRS SRLQTHNSVI GVPIRETPIL DDYDCEEDEE 300
PPRRANHVSR EDEFGSQVTH TLDSLGHPGE EKVDFEKKAA AEATQETVES LMQKFKESFR 360
ANTPIEIGQL QPPLRSTSAG KRKRRSKSRG GISFGRAKGT SGSEADDETQ LTFYTEQYRS 420
RRRSKGLLKS PVNKTALTLI AVSSCILAMV CGSQMSCPLT VKVTLHVPEH FIADGSSFVV 480
SEGSYLDISD WLNPAKLSLY YQINATSPWV RDLCGQRTTD ACEQLCDPET GECSCHEGYA 540
PDPVHRHLCV RSDWGQSEGP WPYTTLERGY DLVTGEQAPE KILRSTFSLG QGLWLPVSKS 600
FVVPPVELSI NPLASCKTDV LVTEDPADVR EEAMLSTYFE TINDLLSSFG PVRDCSRNNG 660
GCTRNFKCVS DRQVDSSGCV CPEELKPMKD GSGCYDHSKG IDCSDGFNGG CEQLCLQQTL 720
PLPYDATSST IFMFCGCVEE YKLAPDGKSC LMLSDVCEGP KCLKPDSKFN DTLFGEMLHG 780
YNNRTQHVNQ GQVFQMTFRE NNFIKDFPQL ADGLLVIPLP VEEQCRGVLS EPLPDLQLLT 840
GDIRYDEAMG YPMVQQWRVR SNLYRVKLST ITLAAGFTNV LKILTKESSR EELLSFIQHY 900
GSHYIAEALY GSELTCIIHF PSKKVQQQLW LQYQKETTEL GSKKELKSMP FITYLSGLLT 960
AQMLSDDQLI SGVEIRCEEK GRCPSTCHLC RRPGKEQLSP TPVLLEINRV VPLYTLIQDN 1020
GTKEAFKSAL MSSYWCSGKG DVIDDWCRCD LSAFDANGLP NCSPLLQPVL RLSPTVEPSS 1080
TVVSLEWVDV QPAIGTKVSD YILQHKKVDE YTDTDLYTGE FLSFADDLLS GLGTSCVAAG 1140
RSHGEVPEVS IYSVIFKCLE PDGLYKFTLY AVDTRGRHSE LSTVTLRTAC PLVDDNKAEE 1200
IADKIYNLYN GYTSGKEQQM AYNTLMEVSA SMLFRVQHHY NSHYEKFGDF VWRSEDELGP 1260
RKAHLILRRL ERVSSHCSSL LRSAYIQSRV ETVPYLFCRS EEVRPAGMVW YSILKDTKIT 1320
CEEKMVSMAR NTYGESKGR 1339

Gene Ontology

GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.

Interpro

IPR026995; Astrotactin.
IPR026997; Astrotactin_2.
IPR003961; Fibronectin_type3.
IPR020864; MACPF.

Pfam

PF01823; MACPF

SMART

SM00060; FN3
SM00457; MACPF

PROSITE

PS00022; EGF_1
PS01186; EGF_2
PS50026; EGF_3
PS50853; FN3

PRINTS