CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004007
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Collagen alpha-2(VI) chain 
Protein Synonyms/Alias
  
Gene Name
 COL6A2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
120SDRASFIKNLQGISSubiquitination[1]
197VAPNQNLKEQGLRDIubiquitination[1]
692SSFKEAVKNLEWIAGubiquitination[1]
708TWTPSALKFAYDRLIubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 Collagen VI acts as a cell-binding protein. 
Sequence Annotation
 DOMAIN 46 234 VWFA 1.
 DOMAIN 615 805 VWFA 2.
 DOMAIN 833 1014 VWFA 3.
 REGION 21 256 Nonhelical region.
 REGION 257 590 Triple-helical region.
 REGION 591 1019 Nonhelical region.
 MOTIF 366 368 Cell attachment site (Potential).
 MOTIF 426 428 Cell attachment site (Potential).
 MOTIF 489 491 Cell attachment site (Potential).
 MOTIF 498 500 Cell attachment site (Potential).
 MOTIF 539 541 Cell attachment site (Potential).
 MOD_RES 701 701 Phosphothreonine.
 MOD_RES 703 703 Phosphothreonine.
 MOD_RES 705 705 Phosphoserine.
 CARBOHYD 140 140 N-linked (GlcNAc...).
 CARBOHYD 327 327 N-linked (GlcNAc...) (Potential).
 CARBOHYD 630 630 N-linked (GlcNAc...) (Potential).
 CARBOHYD 785 785 N-linked (GlcNAc...).
 CARBOHYD 897 897 N-linked (GlcNAc...).
 CARBOHYD 954 954 N-linked (GlcNAc...).  
Keyword
 Alternative splicing; Cell adhesion; Collagen; Complete proteome; Direct protein sequencing; Disease mutation; Extracellular matrix; Glycoprotein; Hydroxylation; Membrane; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Secreted; Signal. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1019 AA 
Protein Sequence
MLQGTCSVLL LWGILGAIQA QQQEVISPDT TERNNNCPEK TDCPIHVYFV LDTSESVTMQ 60
SPTDILLFHM KQFVPQFISQ LQNEFYLDQV ALSWRYGGLH FSDQVEVFSP PGSDRASFIK 120
NLQGISSFRR GTFTDCALAN MTEQIRQDRS KGTVHFAVVI TDGHVTGSPC GGIKLQAERA 180
REEGIRLFAV APNQNLKEQG LRDIASTPHE LYRNDYATML PDSTEIDQDT INRIIKVMKH 240
EAYGECYKVS CLEIPGPSGP KGYRGQKGAK GNMGEPGEPG QKGRQGDPGI EGPIGFPGPK 300
GVPGFKGEKG EFGADGRKGA PGLAGKNGTD GQKGKLGRIG PPGCKGDPGN RGPDGYPGEA 360
GSPGERGDQG GKGDPGRPGR RGPPGEIGAK GSKGYQGNSG APGSPGVKGA KGGPGPRGPK 420
GEPGRRGDPG TKGSPGSDGP KGEKGDPGPE GPRGLAGEVG NKGAKGDRGL PGPRGPQGAL 480
GEPGKQGSRG DPGDAGPRGD SGQPGPKGDP GRPGFSYPGP RGAPGEKGEP GPRGPEGGRG 540
DFGLKGEPGR KGEKGEPADP GPPGEPGPRG PRGVPGPEGE PGPPGDPGLT ECDVMTYVRE 600
TCGCCDCEKR CGALDVVFVI DSSESIGYTN FTLEKNFVIN VVNRLGAIAK DPKSETGTRV 660
GVVQYSHEGT FEAIQLDDER IDSLSSFKEA VKNLEWIAGG TWTPSALKFA YDRLIKESRR 720
QKTRVFAVVI TDGRHDPRDD DLNLRALCDR DVTVTAIGIG DMFHEKHESE NLYSIACDKP 780
QQVRNMTLFS DLVAEKFIDD MEDVLCPDPQ IVCPDLPCQT DAPWPGGEPP VTFLRTEEGP 840
DATFPRTIPL IQQLLNATEL TQDPAAYSQL VAVLVYTAER AKFATGVERQ DWMELFIDTF 900
KLVHRDIVGD PETALALC 918 
Gene Ontology
 GO:0005581; C:collagen; IEA:UniProtKB-KW.
 GO:0005788; C:endoplasmic reticulum lumen; TAS:Reactome.
 GO:0005615; C:extracellular space; IDA:BHF-UCL.
 GO:0043234; C:protein complex; IPI:MGI.
 GO:0005578; C:proteinaceous extracellular matrix; NAS:UniProtKB.
 GO:0042383; C:sarcolemma; IEA:Compara.
 GO:0005201; F:extracellular matrix structural constituent; NAS:UniProtKB.
 GO:0030674; F:protein binding, bridging; NAS:UniProtKB.
 GO:0007411; P:axon guidance; TAS:Reactome.
 GO:0016337; P:cell-cell adhesion; NAS:UniProtKB.
 GO:0030574; P:collagen catabolic process; TAS:Reactome.
 GO:0022617; P:extracellular matrix disassembly; TAS:Reactome.
 GO:0070208; P:protein heterotrimerization; IPI:MGI. 
Interpro
 IPR008160; Collagen.
 IPR002035; VWF_A. 
Pfam
 PF01391; Collagen
 PF00092; VWA 
SMART
 SM00327; VWA 
PROSITE
 PS50234; VWFA 
PRINTS