CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041944
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 E3 ubiquitin-protein ligase TTC3 
Protein Synonyms/Alias
 Tetratricopeptide repeat domain 3, isoform CRA_b 
Gene Name
 Ttc3 
Gene Synonyms/Alias
 mCG_19601 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
470DLKSILEKQFSKSSRubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Metal-binding; Reference proteome; Repeat; TPR repeat; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1979 AA 
Protein Sequence
MDDFAEGGLS LADDILLEDY PYEDDCICTP DFTTDDYVRV TQLYYEGVGM QYKDYAQSEK 60
NLEYDICNIW CSKPLSILQD YCDAIKLYIF WPLLFQHQHS SIISRLHPCV EAIRSRAAEI 120
SLKKLQHLEL MEDIVDLAKK VANDSFLIEG LLKIGYKIEN KILAMEDALN WIKYTGDVTI 180
LPKLGSVDNC WPMLSIFFTE YKYHITRVVT ENCNLLEEFR RHSCMQCVKQ GELMKMRGNE 240
EFSKEKFEIA VIYYTRAIEY RPENHLLYGN RALCFLRMGQ FRNALSDGKR AIVLKNTWPK 300
GHYRYCDALC MLGEYDWALQ ANIKAQKLCK NDPEGIKDLI QQHVKLQKQI EDLQGRTSNK 360
NPIKAFYESR AYIPRNSSAP AFRTSLNFVE TERGFRKTKY KMANGGDQNQ KVADEALKGD 420
DCDCHPEFLP PPSQPPRHKG KQKSRNNESE KPSSNSEVSL QVDLKSILEK QFSKSSRAAH 480
QDFANIMKML RSLIQDGYTA LLEQRCRSAA QAFTELLNGL DPQKIKQLNL AMINYVLVVY 540
GLAVSLLGIG RPEELSEAEN QFKRIIEHYP NEGLDCLAYC GIGKVYLKKN RFLEALNHFE 600
KAKTLISRLP GILTWPTSNV IIEESKPEKV KVMLEKFVEE CKFPPVPDAV CCYQKCRGYS 660
KIQIYLTDPD FKGFIRISCC QYCKVEFHMN CWKKLKTTTF NDKIDKDFLQ GICLTPDCEG 720
IISKIIIYSS GGQVKCEFEH KVIKEKVPSR PVLKQKCSSL EKLRLKEDKK LKRKIQKQEA 780
KKLAQERMEE DLRESNPPKN EEPEETSDSA QRCQFLDDRI LQCIKQNADK IKSVVLNTST 840
LLKELLSWKV LSTEDYTTCF SSKNFVHEAV DYVIGHLIQE KNRVKTRIFL HVLSELKELD 900
PKLAPWIQRL NSFGLDAIGP FFTRYGASLK ELDFHVVTVL WDEKYGHKLG SIEGKQLDYF 960
FEPASAMEAR CLIWLLEEHR DKFPALHSAL DEFFDIMDSR CTVLRKQDSD EMPFGCIKVK 1020
NKGKKKKPKD SKPMLVGSGA ASVAPSSEAV TPEDHSRRNS DSAGPFAVPD HLRQDVEEFE 1080
ALYDQHSSEY VVRNKKLWDI NPKQKCSTLY DYFSQLLEEH GPLDMSDRMF SEEYEFFPEE 1140
TRQILEKAGG LKSFLLGCPR FVVIDNCIAL KKVASRLKKK RKKKNMKAKV EDISKTGEYL 1200
RVKLPLNPTA REFQPDVKSE ALSEDVKSIP GPADSSTLAA EDLKAQLDSD SSSGSASEDS 1260
RLEVASPDSP TPLCEDASPS PTPAPEEAKP TYWAQSHLVT GFCTYLPFQG FGITQRPAYI 1320
NMVPSLSQFT SIYTPLANIS SEYPMQRSMP VVPSFVASNR ADENAAAYFE SPNLNTEHDS 1380
GDHMASETQI LEDTLGVCVR SQGSAADADP ALSEPEGNSE HSGSSDSLWE ASLENVSGTT 1440
DAPAAPSVAI QVSRSMVHQE VNTEPYEPFE TQQGDLSQKE KECHLLREQL KVACENCEQI 1500
ELRSSQEIKD LEEKLQRHTE ENKISKTELD WFLQDLDREI KKWQQEKKEI QERLKALKKK 1560
IKKVINTSEM PAQKNDGFDK ECEPHPDQSL GFSSALTDEK TKVEESVRKG KELYEESHQR 1620
AVAAEVSVLE NWKEREVCKL QGVASQSEAY LKSLKLMSSD SATYPDVEYD ILSWESFLST 1680
VREEIESKKS QFEEHIKAIK NGSRLSDLSS VQLSEVSFPG CSTIHPQFLS ESSGHEDPGL 1740
VACVDSMTGA VLNDPYMDSA SGCPEEVPEL SLGSPTHQPE VTQQLELKGA SQVSPSEQSP 1800
EADEKLSGQA TRSSQSPKKP SNSIIEHLSV IFPCYTSTEL AGFIKKVRNK TKNSFSGLTI 1860
EEIVEKVTEH IVDEQKKKKP NPGKDKKTSE AHSAASVAKS SQSPPLAAAG PSARTKGQKK 1920
DDVPAPDGNS CEICHEIFKS KNMRVLKCGH KFHKGCFKQW LKGQSTCPTC GSSDLLSEE 1979 
Gene Ontology
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0005773; C:vacuole; IDA:MGI.
 GO:0004842; F:ubiquitin-protein ligase activity; IEA:Compara.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0010771; P:negative regulation of cell morphogenesis involved in differentiation; IDA:MGI.
 GO:0045665; P:negative regulation of neuron differentiation; IDA:MGI.
 GO:0070936; P:protein K48-linked ubiquitination; IEA:Compara.
 GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:Compara. 
Interpro
 IPR001440; TPR-1.
 IPR013026; TPR-contain_dom.
 IPR011990; TPR-like_helical.
 IPR019734; TPR_repeat.
 IPR001841; Znf_RING.
 IPR013083; Znf_RING/FYVE/PHD. 
Pfam
 PF00515; TPR_1
 PF13639; zf-RING_2 
SMART
 SM00184; RING
 SM00028; TPR 
PROSITE
 PS50005; TPR
 PS50293; TPR_REGION
 PS50089; ZF_RING_2 
PRINTS