CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-034081
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Phosphomevalonate kinase 
Protein Synonyms/Alias
  
Gene Name
 Pmvk 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
48LRLSGPLKEEYAREHacetylation[1, 2]
48LRLSGPLKEEYAREHubiquitination[3]
69LLDASTYKETYRRDMacetylation[4]
69LLDASTYKETYRRDMsuccinylation[4]
69LLDASTYKETYRRDMubiquitination[3]
94DPGFFCRKIVEGVSQacetylation[1]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [4] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 158 AA 
Protein Sequence
MAPLGASPRL VLLFSGKRKS GKDFVTERLK SRLGGNICAL LRLSGPLKEE YAREHGLDFQ 60
RLLDASTYKE TYRRDMICWG EQKRQADPGF FCRKIVEGVS QPIWLVSDTR RTSDIQWFQE 120
AYGAVIQTVR VVASEQSRQQ RGWVFTPGRG HSASLGHL 158 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:InterPro.
 GO:0004631; F:phosphomevalonate kinase activity; IDA:MGI.
 GO:0006695; P:cholesterol biosynthetic process; IEA:InterPro. 
Interpro
 IPR027417; P-loop_NTPase.
 IPR005919; Pmev_kin_anim. 
Pfam
 PF04275; P-mevalo_kinase 
SMART
  
PROSITE
  
PRINTS