UniProt Accession

 SAC31_HUMAN; A6NKF1; A8MX08; Q99773 

Genbank Protein ID

 U79266; AP003068; BC007448 

Genbank Nucleotide ID

 AAB50210.1 

Protein Name

 SAC3 domain-containing protein 1 

Protein Synonyms/Alias

 SAC3 homology domain-containing protein 1 

Gene Name

 SAC3D1 

Gene Synonyms/Alias

 SHD1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
261	RACPPLRKALAVDAA	ubiquitination	[1, 2]
372	LPPASTCKVLVESKL	acetylation	[3]
378	CKVLVESKLRGRTLE	acetylation	[3]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 

Functional Description

 Involved in centrosome duplication and mitotic progression (By similarity). 

Sequence Annotation

 MOD_RES 402 402 Phosphoserine.  

Keyword

 Alternative splicing; Cell cycle; Cell division; Complete proteome; Cytoplasm; Cytoskeleton; Mitosis; Phosphoprotein; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 404 AA 

Protein Sequence

Gene Ontology

 GO:0005813; C:centrosome; IEA:Compara.
 GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
 GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0051298; P:centrosome duplication; IEA:Compara.
 GO:0007067; P:mitosis; IEA:UniProtKB-KW.
 GO:0051225; P:spindle assembly; IEA:Compara. 

Interpro

 IPR005062; SAC3/GANP/Nin1/mts3/eIF-3-p25. 

Pfam

 PF03399; SAC3_GANP 

SMART

  

PROSITE

  

PRINTS