UniProt Accession

 ATRAP_MOUSE; Q9WVK0; B2KFL8; Q3U7X6; Q9D8Z8; Q9D940 

Genbank Protein ID

 AF102548; AK007383; AK007502; AK036598; AK152467; CU207376; AL606929; CH466594; BC046820; BC057196 

Genbank Nucleotide ID

 AAD25997.1; BAB25001.1; BAB25074.1; BAC29501.1; BAE31243.1; CAQ51920.1; CAM14899.1; EDL14800.1; AAH46820.1; AAH57196.1 

Protein Name

 Type-1 angiotensin II receptor-associated protein 

Protein Synonyms/Alias

 AT1 receptor-associated protein 

Gene Name

 Agtrap 

Gene Synonyms/Alias

 Atrap 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
153	PFASLENKGQAVPRG	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in angiotensin II-stimulated transcriptional activity. May play a role of negative regulator in cardiomyocyte hypertrophy induced by angiotensin II through an inhibition of p38 mitogen-activated protein kinase pathway. 

Sequence Annotation

 REGION 110 122 Interaction with AGTR1 (By similarity).  

Keyword

 Complete proteome; Cytoplasmic vesicle; Endoplasmic reticulum; Golgi apparatus; Membrane; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 161 AA 

Protein Sequence

Gene Ontology

 GO:0005938; C:cell cortex; IDA:UniProtKB.
 GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IDA:UniProtKB.
 GO:0004945; F:angiotensin type II receptor activity; IMP:MGI.
 GO:0008217; P:regulation of blood pressure; IMP:MGI.
 GO:0001666; P:response to hypoxia; IEA:Compara. 

Interpro

 IPR009436; Angiotensin_II_typ1_rcpt-assoc. 

Pfam

 PF06396; AGTRAP 

SMART

 SM00805; AGTRAP 

PROSITE

  

PRINTS