CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-043050
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Isocitrate dehydrogenase [NADP], mitochondrial 
Protein Synonyms/Alias
  
Gene Name
 IDH2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
48DKRIKVAKPVVEMDGacetylation[1]
Reference
 [1] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Oxidoreductase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 312 AA 
Protein Sequence
MAGYLRVVRS LCRASGSRPA WAPAALTAPT SQEQPRRHYA DKRIKVAKPV VEMDGDEMTR 60
IIWQFIKEKY KATDFVADRA GTFKMVFTPK DGSGVKEWEV YNFPAGGVGM GMYNTDESIS 120
GFAHSCFQYA IQKKWPLYMS TKNTILKAYD GRFKDIFQEI FDKHYKTDFD KNKIWYEHRL 180
IDDMVAQVLK SSGGFVWACK NYDGDVQSDI LAQGFGSLGL MTSVLVCPDG KTIEAEAAHG 240
TVTRHYREHQ KGRPTSTNPI ASIFAWTRGL EHRGKLDGNQ DLISVKLNEH FLNTTDFLDT 300
IKSNLDRALG RQ 312 
Gene Ontology
 GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:InterPro.
 GO:0000287; F:magnesium ion binding; IEA:InterPro.
 GO:0051287; F:NAD binding; IEA:InterPro.
 GO:0006102; P:isocitrate metabolic process; IEA:InterPro. 
Interpro
 IPR019818; IsoCit/isopropylmalate_DH_CS.
 IPR004790; Isocitrate_DH_NADP.
 IPR024084; IsoPropMal-DH-like_dom. 
Pfam
 PF00180; Iso_dh 
SMART
  
PROSITE
 PS00470; IDH_IMDH 
PRINTS