CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-040798
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Catenin alpha-1 
Protein Synonyms/Alias
  
Gene Name
 CTNNA1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
468EPGVYTEKVLEATKLubiquitination[1]
474EKVLEATKLLSNTVMubiquitination[2]
580LPQEQKAKIAEQVASubiquitination[1]
592VASFQEEKSKLDAEVubiquitination[1, 3]
694LNICSKVKAEVQNLGubiquitination[4]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level.
 Danielsen JM, Sylvestersen KB, Bekker-Jensen S, Szklarczyk D, Poulsen JW, Horn H, Jensen LJ, Mailand N, Nielsen ML.
 Mol Cell Proteomics. 2011 Mar;10(3):M110.003590. [PMID: 21139048] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 803 AA 
Protein Sequence
MKAAAGEFAD DPCSSVKRGN MVRAARALLS AVTRLLILAD MADVYKLLVQ LKVVEDGILK 60
LRNAGNEQDL GIQYKALKPE VDKLNIMAAK RQQELKDVGH RDQMAAARGI LQKNVPILYT 120
ASQACLQHPD VAAYKANRDL IYKQLQQAVT GISNAAQATA SDDASQHQGG GGGELAYALN 180
NFDKQIIVDP LSFSEERFRP SLEERLESII SGAALMADSS CTRDDRRERI VAECNAVRQA 240
LQDLLSEYMG NAGRKERSDA LNSAIDKMTK KTRDLRRQLR KAVMDHVSDS FLETNVPLLV 300
LIEAAKNGNE KEVKEYAQVF REHANKLIEV ANLACSISNN EEGVKLVRMS ASQLEALCPQ 360
VINAALALAA KPQSKLAQEN MDLFKEQWEK QVRVLTDAVD DITSIDDFLA VSENHILEDV 420
NKCVIALQEK DVDGLDRTAG AIRGRAARVI HVVTSEMDNY EPGVYTEKVL EATKLLSNTV 480
MPRFTEQVEA AVEALSSDPA QPMDENEFID ASRLVYDGIR DIRKAVLMIR TPEELDDSDF 540
ETEDFDVRSR TSVQTEDDQL IAGQSARAIM AQLPQEQKAK IAEQVASFQE EKSKLDAEVS 600
KWDDSGNDII VLAKQMCMIM MEMTDFTRGK GPLKNTSDVI SAAKKIAEAG SRMDKLGRTI 660
ADHCPDSACK QDLLAYLQRI ALYCHQLNIC SKVKAEVQNL GGELVVSGVD SAMSLIQAAK 720
NLMNAVVQTV KASYVASTKY QKSQGMASLN LPAVSWKMKA PEKKPLVKRE KQDETQTKIK 780
RASQKKHVNP VQALSEFKAM DSI 803 
Gene Ontology
 GO:0001669; C:acrosomal vesicle; IEA:Compara.
 GO:0015629; C:actin cytoskeleton; IEA:InterPro.
 GO:0014704; C:intercalated disc; IEA:Compara.
 GO:0030027; C:lamellipodium; IEA:Compara.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0005915; C:zonula adherens; IEA:Compara.
 GO:0005198; F:structural molecule activity; IEA:InterPro.
 GO:0007568; P:aging; IEA:Compara.
 GO:0043297; P:apical junction assembly; IEA:Compara.
 GO:0031103; P:axon regeneration; IEA:Compara.
 GO:0007155; P:cell adhesion; IEA:InterPro.
 GO:0007163; P:establishment or maintenance of cell polarity; IEA:Compara.
 GO:0016264; P:gap junction assembly; IEA:Compara.
 GO:0008584; P:male gonad development; IEA:Compara.
 GO:0043066; P:negative regulation of apoptotic process; IEA:Compara.
 GO:0007406; P:negative regulation of neuroblast proliferation; IEA:Compara.
 GO:0042475; P:odontogenesis of dentin-containing tooth; IEA:Compara.
 GO:0001541; P:ovarian follicle development; IEA:Compara.
 GO:0045880; P:positive regulation of smoothened signaling pathway; IEA:Compara.
 GO:0051291; P:protein heterooligomerization; IEA:Compara.
 GO:0043627; P:response to estrogen stimulus; IEA:Compara. 
Interpro
 IPR001033; Alpha_catenin.
 IPR006077; Vinculin/catenin.
 IPR000633; Vinculin_CS. 
Pfam
 PF01044; Vinculin 
SMART
  
PROSITE
 PS00663; VINCULIN_1 
PRINTS
 PR00805; ALPHACATENIN.