CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-027177
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Full-length cDNA clone CS0DI002YH20 of Placenta of Homo sapiens (human) 
Protein Synonyms/Alias
 Legumain 
Gene Name
 LGMN 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
224YACYYDEKRSTYLGDubiquitination[1, 2]
316DVPLTIMKRKLMNTNubiquitination[1, 3]
318PLTIMKRKLMNTNDLubiquitination[3]
342IQRHLDDKIVHGPRVubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 372 AA 
Protein Sequence
MVWKVAVFLS VALGIGAVPI DDPEDGGKHW VVIVAGSNGW YNYRHQADAC HAYQIIHRNG 60
IPDEQIVVMM YDDIAYSEDN PTPGIVINRP NGTDVYQGVP KDYTGEDVTP QNFLAVLRGD 120
AEAVKGIGSG KVLKSGPQDH VFIYFTDHGS TGILVFPNED LHVKDLNETI HYMYKHKMYR 180
KMVFYIEACE SGSMMNHLPD NINVYATTAA NPRESSYACY YDEKRSTYLG DWYSVNWMED 240
SDVEDLTKET LHKQYHLVKS HTNTSHVMQY GNKTISTMKV MQFQGMKRKA SSPVPLPPVT 300
HLDLTPSPDV PLTIMKRKLM NTNDLEESRQ LTEEIQRHLD DKIVHGPRVP WSLLKSCLLE 360
AFPSVSAPPT VC 372 
Gene Ontology
 GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
 GO:0006508; P:proteolysis; IEA:InterPro. 
Interpro
 IPR001096; Peptidase_C13. 
Pfam
 PF01650; Peptidase_C13 
SMART
  
PROSITE
  
PRINTS
 PR00776; HEMOGLOBNASE.