UniProt Accession

 H11_MOUSE; P43275; Q5SZ98 

Genbank Protein ID

 L26164; Y12290; AY158903; AL590388; CH466561; BC116820; BC116850 

Genbank Nucleotide ID

 AAA37761.1; CAA72969.1; AAO06214.1; CAI25836.1; EDL32534.1; AAI16821.1; AAI16851.1 

Protein Name

 Histone H1.1 

Protein Synonyms/Alias

 H1 VAR.3; Histone H1a; H1a 

Gene Name

 Hist1h1a 

Gene Synonyms/Alias

 H1a; H1f1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
17	AASTATEKPAAAKKT	acetylation	[1, 2, 3, 4]
17	AASTATEKPAAAKKT	succinylation	[4]
22	TEKPAAAKKTKKPAK	acetylation	[1]
35	AKAAAPRKKPAGPSV	ubiquitination	[5]
36	KAAAPRKKPAGPSVS	ubiquitination	[5]
54	VQAVSSSKERSGVSL	acetylation	[3]
54	VQAVSSSKERSGVSL	ubiquitination	[5]
66	VSLAALKKSLAAAGY	acetylation	[4]
66	VSLAALKKSLAAAGY	succinylation	[4]
66	VSLAALKKSLAAAGY	ubiquitination	[5]
77	AAGYDVEKNNSRIKL	acetylation	[3, 4]
77	AAGYDVEKNNSRIKL	ubiquitination	[6]
87	SRIKLGLKSLVNKGT	acetylation	[1, 3, 4]
92	GLKSLVNKGTLVQTK	acetylation	[3, 4]
99	KGTLVQTKGTGAAGS	acetylation	[3, 4]
99	KGTLVQTKGTGAAGS	succinylation	[4]
99	KGTLVQTKGTGAAGS	ubiquitination	[5]
108	TGAAGSFKLNKKAES	acetylation	[3]
108	TGAAGSFKLNKKAES	ubiquitination	[5]
121	ESKAITTKVSVKAKA	acetylation	[1, 3, 4]

Reference

 [1] Mass spectrometric mapping of linker histone H1 variants reveals multiple acetylations, methylations, and phosphorylation as well as differences between cell culture and tissue.
 Wisniewski JR, Zougman A, Krüger S, Mann M.
 Mol Cell Proteomics. 2007 Jan;6(1):72-87. [PMID: 17043054]
 [2] Comprehensive mapping of post-translational modifications on synaptic, nuclear, and histone proteins in the adult mouse brain.
 Tweedie-Cullen RY, Reck JM, Mansuy IM.
 J Proteome Res. 2009 Nov;8(11):4966-82. [PMID: 19737024]
 [3] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [4] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [5] BTB-ZF factors recruit the E3 ligase cullin 3 to regulate lymphoid effector programs.
 Mathew R, Seiler MP, Scanlon ST, Mao AP, Constantinides MG, Bertozzi-Villa C, Singer JD, Bendelac A.
 Nature. 2012 Nov 22;491(7425):618-21. [PMID: 23086144]
 [6] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). 

Sequence Annotation

 DOMAIN 38 111 H15.
 MOD_RES 106 106 Phosphoserine (By similarity).  

Keyword

 Chromosome; Complete proteome; DNA-binding; Nucleus; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 213 AA 

Protein Sequence

Gene Ontology

 GO:0000790; C:nuclear chromatin; IEA:Compara.
 GO:0000786; C:nucleosome; IEA:InterPro.
 GO:0003677; F:DNA binding; IDA:MGI.
 GO:0006334; P:nucleosome assembly; IEA:InterPro.
 GO:0007283; P:spermatogenesis; IGI:MGI. 

Interpro

 IPR005818; Histone_H1/H5.
 IPR005819; Histone_H5.
 IPR011991; WHTH_DNA-bd_dom. 

Pfam

 PF00538; Linker_histone 

SMART

 SM00526; H15 

PROSITE

 PS51504; H15 

PRINTS

 PR00624; HISTONEH5.