UniProt Accession

 SNF8_HUMAN; Q96H20; Q8IXY3; Q9UN50 

Genbank Protein ID

 AF156102; BC008976; BC038830 

Genbank Nucleotide ID

 AAD46560.1; AAH08976.1; AAH38830.1 

Protein Name

 Vacuolar-sorting protein SNF8 

Protein Synonyms/Alias

 ELL-associated protein of 30 kDa; ESCRT-II complex subunit VPS22; hVps22 

Gene Name

 SNF8 

Gene Synonyms/Alias

 EAP30 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
38	DQLAQMSKQLDMFKT	ubiquitination	[1]
134	QVLKGRGKFAQDVSQ	ubiquitination	[1]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation by participating in derepression of transcription by RNA polymerase II, possibly via its interaction with ELL. Required for degradation of both endocytosed EGF and EGFR, but not for the EGFR ligand-mediated internalization. It is also required for the degradation of CXCR4. 

Sequence Annotation

  

Keyword

 3D-structure; Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; Endosome; Membrane; Nucleus; Protein transport; Reference proteome; Transcription; Transcription regulation; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 258 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
 GO:0005667; C:transcription factor complex; IDA:MGI.
 GO:0008134; F:transcription factor binding; IDA:MGI.
 GO:0016044; P:cellular membrane organization; TAS:Reactome.
 GO:0016197; P:endosomal transport; TAS:Reactome.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW.
 GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IDA:MGI.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR007286; EAP30.
 IPR016689; ESCRT-2_cplx_Snf8.
 IPR011991; WHTH_DNA-bd_dom. 

Pfam

 PF04157; EAP30 

SMART

  

PROSITE

  

PRINTS