CPLM-021018

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-021018

UniProt Accession

K2C7_MOUSE; Q9DCV7

Genbank Protein ID

AF509888; AF509890; AK002434; AK137217; AK146914; BC030403

Genbank Nucleotide ID

AAN64032.1; AAN64034.1; BAB22099.1; BAE23275.1; BAE27526.1; AAH30403.1

Protein Name

Keratin, type II cytoskeletal 7

Protein Synonyms/Alias

Cytokeratin-7; CK-7; Keratin-7; K7; Type-II keratin Kb7

Gene Name

Krt7

Gene Synonyms/Alias

Krt2-7

Created Date

July 27, 2013

Organism

Mus musculus (Mouse)

NCBI Taxa ID

10090

Lysine Modification

Position	Peptide	Type	References
95	QIKTLNNKFASFIDK	ubiquitination	[1]
102	KFASFIDKVRFLEQQ	ubiquitination	[1]
320	QAEIDTLKNQRAKLE	ubiquitination	[1]

Reference

[1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]

Functional Description

Blocks interferon-dependent interphase and stimulates DNA synthesis in cells (By similarity).

Sequence Annotation

REGION 2 84 Head.
REGION 84 120 Coil 1A.
REGION 85 393 Rod.
REGION 121 138 Linker 1.
REGION 139 230 Coil 1B.
REGION 231 254 Linker 12.
REGION 255 393 Coil 2.
REGION 394 457 Tail.
MOD_RES 2 2 N-acetylserine (By similarity).
MOD_RES 2 2 Phosphoserine (By similarity).
MOD_RES 15 15 Dimethylated arginine; alternate (By
MOD_RES 15 15 Omega-N-methylarginine; alternate (By
MOD_RES 173 173 N6-acetyllysine (By similarity).
MOD_RES 246 246 Phosphoserine (By similarity).
MOD_RES 248 248 Phosphoserine (By similarity).

Keyword

Acetylation; Coiled coil; Complete proteome; Direct protein sequencing; Intermediate filament; Keratin; Methylation; Phosphoprotein; Reference proteome.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

457 AA

Protein Sequence

MSIHFSSRST AYPGRGAQVR LSSGRASFGS RSLYGLGSSR PRVAVRSAYG GPVGAGIREI 60
TINQSLLAPL SVDIDPTIQQ VRQEEREQIK TLNNKFASFI DKVRFLEQQN KMLETKWALL 120
QEQKSAKSSQ LPRIFEAQIA GLRQQLETLQ LDGGRLEVEL RNMQDVVEDF KNKYEEEINR 180
RTAAENEFVL LKKDVDAAYT NKVELEAKAD SLQDEINFLK TLHETELAEL QSQISDTSVV 240
LSMDNSRSLD LDGIIADVKA QYEEMANHSR AEAEAWYQTK FETLQAQAGK HGDDLRNTRN 300
EIAEMNRSIQ RLQAEIDTLK NQRAKLESSI AEAEEQGELA IKDAHAKQGE LEAALQKAKQ 360
DVARQLREYQ ELLNTKLALD IEIATYRKLL EGEESRLSGD GMGPVNISVV NSTGGNGGKL 420
IFGGTMGSNA LSFSGGPGAL RAYSIKTTST TRRGTHN 457

Gene Ontology

GO:0005794; C:Golgi apparatus; IEA:Compara.
GO:0045095; C:keratin filament; IEA:InterPro.
GO:0005634; C:nucleus; IEA:Compara.
GO:0005198; F:structural molecule activity; IEA:InterPro.
GO:0006260; P:DNA replication; IEA:Compara.
GO:0006417; P:regulation of translation; ISS:UniProtKB.

Interpro

IPR016044; F.
IPR001664; IF.
IPR018039; Intermediate_filament_CS.
IPR003054; Keratin_II.
IPR009053; Prefoldin.

Pfam

PF00038; Filament

SMART

PROSITE

PS00226; IF

PRINTS

PR01276; TYPE2KERATIN.