CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-001385
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Actin-related protein 2/3 complex subunit 1B 
Protein Synonyms/Alias
 Arp2/3 complex 41 kDa subunit; p41-ARC 
Gene Name
 Arpc1b 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
44KSGAKWNKVHELKEHacetylation[1]
49WNKVHELKEHNGQVTacetylation[1]
82NAYVWTLKGRTWKPTacetylation[1]
174RIFSAYIKEVEERPAacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks (By similarity). 
Sequence Annotation
 REPEAT 6 45 WD 1.
 REPEAT 50 89 WD 2.
 REPEAT 94 135 WD 3.
 REPEAT 140 179 WD 4.
 REPEAT 242 280 WD 5.
 REPEAT 324 367 WD 6.
 MOD_RES 82 82 N6-acetyllysine (By similarity).
 MOD_RES 310 310 Phosphoserine (By similarity).  
Keyword
 Acetylation; Actin-binding; Complete proteome; Cytoplasm; Cytoskeleton; Phosphoprotein; Reference proteome; Repeat; WD repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 372 AA 
Protein Sequence
MAYHSFLVEP ISCHAWNKDR TQIAICPNNH EVHIYEKSGA KWNKVHELKE HNGQVTGIDW 60
APESNRIVTC GTDRNAYVWT LKGRTWKPTL VILRINRAAR CVRWAPNENK FAVGSGSRVI 120
SICYFEQEND WWVCKHIKKP IRSTVLSLDW HPNNVLLAAG SCDFKCRIFS AYIKEVEERP 180
APTPWGSKMP FGELMFESSS SCGWVHGVCF SAGGSRVAWV SHDSTVCLVD AEKKMAVATL 240
ASETLPLLAI TFITENSLVA AGHDCFPVLF TYDNAAGTLS FGGRLDVPKQ NSQRGLTARE 300
RFQNLDKKAS SEGGAATGAG LDSLHKNSVS QISVLSGGKA KCSQFCTTGM DGGMSIWDVK 360
SLESALKDLK IR 372 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
 GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
 GO:0030833; P:regulation of actin filament polymerization; IEA:InterPro. 
Interpro
 IPR017383; ARPC2/3_su1.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR017986; WD40_repeat_dom. 
Pfam
 PF00400; WD40 
SMART
 SM00320; WD40 
PROSITE
 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 
PRINTS