CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022123
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Uncharacterized protein C1orf112 
Protein Synonyms/Alias
  
Gene Name
 C1orf112 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
25QVLPKTVKLFDDMMYubiquitination[1, 2, 3, 4]
198LKHQSIIKSQLKHKDubiquitination[2]
244ADYRLFQKTLKLCRFubiquitination[3]
523FIQKFSPKEAENLPLubiquitination[3]
748KVVSFLEKTGFVDETubiquitination[3]
759VDETEAAKVERVKQEubiquitination[3, 5]
783NVTVEEAKRSSLQPYubiquitination[3]
792SSLQPYAKRARQEFPacetylation[6]
792SSLQPYAKRARQEFPubiquitination[3]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [6] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861
Functional Description
  
Sequence Annotation
 MOD_RES 792 792 N6-acetyllysine.  
Keyword
 Acetylation; Alternative splicing; Complete proteome; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 853 AA 
Protein Sequence
MFLPHMNHLT LEQTFFSQVL PKTVKLFDDM MYELTSQARG LSSQNLEIQT TLRNILQTMV 60
QLLGALTGCV QHICATQESI ILENIQSLPS SVLHIIKSTF VHCKNSESVY SGCLHLVSDL 120
LQALFKEAYS LQKQLMELLD MVCMDPLVDD NDDILNMVIV IHSLLDICSV ISSMDHAFHA 180
NTWKFIIKQS LKHQSIIKSQ LKHKDIITSL CEDILFSFHS CLQLAEQMTQ SDAQDNADYR 240
LFQKTLKLCR FFANSLLHYA KEFLPFLSDS CCTLHQLYLQ IHSKFPPSLY ATRISKAHQE 300
EIAGAFLVTL DPLISQLLTF QPFMQVVLDS KLDLPCELQF PQCLLLVVVM DKLPSQPKEV 360
QTLWCTDSQV SETTTRISLL KAVFYSFEQC SGELSLPVHL QGLKSKGKAE VAVTLYQHVC 420
VHLCTFITSF HPSLFAELDA ALLNAVLSAN MITSLLAMDA WCFLARYGTA ELCAHHVTIV 480
AHLIKSCPGE CYQLINLSIL LKRLFFFMAP PHQLEFIQKF SPKEAENLPL WQHISFQALP 540
PELREQTVHE VTTVGTAECR KWLSRSRTLG ELESLNTVLS ALLAVCNSAG EALDTGKQTA 600
IIEVVSQLWA FLNIKQVADQ PYVQQTFSLL LPLLGFFIQT LDPKLILQAV TLQTSLLKLE 660
LPDYVRLAML DFVSSLGKLF IPEAIQDRIL PNLSCMFALL LADRSWLLEQ HTLEAFTQFA 720
EGTNHEEIVP QCLSSEETKN KVVSFLEKTG FVDETEAAKV ERVKQEKGIF WEPFANVTVE 780
EAKRSSLQPY AKRARQEFPW EEEYRSALHT IAGALEATES LLQKGPAPAW LSMEMEALQE 840
RMDKLKRYIH TLG 853 
Gene Ontology
  
Interpro
  
Pfam
  
SMART
  
PROSITE
  
PRINTS