UniProt Accession

 GPX8_HUMAN; Q8TED1 

Genbank Protein ID

 AY358715; AK074216; AC091977; CH471123; BC029424 

Genbank Nucleotide ID

 AAQ89077.1; BAB85019.1; EAW54908.1; AAH29424.1 

Protein Name

 Probable glutathione peroxidase 8 

Protein Synonyms/Alias

 GPx-8; GSHPx-8 

Gene Name

 GPX8 

Gene Synonyms/Alias

 UNQ847/PRO1785 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
10	PLAAYPLKCSGPRAK	ubiquitination	[1]
128	EVESFARKNYGVTFP	ubiquitination	[2, 3]
141	FPIFHKIKILGSEGE	ubiquitination	[1]

Reference

 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

  

Sequence Annotation

 ACT_SITE 79 79 By similarity.  

Keyword

 3D-structure; Complete proteome; Membrane; Oxidoreductase; Peroxidase; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 209 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0004602; F:glutathione peroxidase activity; IEA:EC.
 GO:0006979; P:response to oxidative stress; IEA:InterPro. 

Interpro

 IPR013376; Glut_perox_Gpx7.
 IPR000889; Glutathione_peroxidase.
 IPR012336; Thioredoxin-like_fold. 

Pfam

 PF00255; GSHPx 

SMART

  

PROSITE

 PS00460; GLUTATHIONE_PEROXID_1
 PS00763; GLUTATHIONE_PEROXID_2
 PS51355; GLUTATHIONE_PEROXID_3 

PRINTS

 PR01011; GLUTPROXDASE.