| Tag | Content |
|---|
| CPLM ID | CPLM-014955 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Keratin, type II cytoskeletal 1 |
Protein Synonyms/Alias | Cytokeratin-1; CK-1; Keratin-1; K1; Type-II keratin Kb1 |
Gene Name | Krt1 |
Gene Synonyms/Alias | Kb1 |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 189 | QIKSLNDKFASFIDK | acetylation | [1] | | 196 | KFASFIDKVRFLEQQ | acetylation | [1] | | 245 | RRQVDSLKNDQSRMD | acetylation | [1] | | 256 | SRMDSELKNMQDLVE | acetylation | [1] | | 287 | ENEFVTIKKDVDSAY | acetylation | [1] | | 288 | NEFVTIKKDVDSAYM | acetylation | [1] | | 297 | VDSAYMNKAELQARV | acetylation | [1] | | 365 | DSICQRSKAEAETFY | acetylation | [1] | | 375 | AETFYQSKYEELQIT | acetylation | [1] | | 385 | ELQITAGKHGDSVKN | acetylation | [1] | | 394 | GDSVKNTKMEISELN | acetylation | [1] | | 415 | RSEIDSVKKQISQMQ | acetylation | [1] | | 434 | DAEQRGEKALKDAQN | acetylation | [1] | | 442 | ALKDAQNKLNEIEDA | acetylation | [1] | | 454 | EDALTQAKEELTRLL | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein kinase C (RACK1/GNB2L1). activated protein kinase C (RACK1/GNB2L1). In complex with C1QBP is a high affinty receptor for kininogen-1/HMWK (By similarity). |
Sequence Annotation | REGION 2 178 Head.
REGION 179 488 Rod.
REGION 179 214 Coil 1A.
REGION 215 233 Linker 1.
REGION 234 325 Coil 1B.
REGION 326 349 Linker 12.
REGION 350 488 Coil 2.
REGION 489 625 Tail.
MOD_RES 26 26 Phosphoserine (By similarity).
MOD_RES 69 69 Phosphoserine (By similarity).
MOD_RES 275 275 N6,N6-dimethyllysine (By similarity). |
Keyword | Cell membrane; Citrullination; Coiled coil; Complete proteome; Intermediate filament; Keratin; Membrane; Methylation; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 625 AA |
Protein Sequence | MSFQCSSRSL CRSGGGGGGR NFSSGSAGLV SFQRRSTSSS MRRSGGGGGG RFSGGGFCGS 60
SGGGFGSKSL VNLGGGRSIS ISVAGGGSSY GGGFGGGSYG GGSFGGGSFG GGVGGGFGGG 120
GFGGGGFGSG GGFGGGRFGG GFGPVCPPGG IQEVTINQSL LQPLNVEVDP QIQKVKSQER 180
EQIKSLNDKF ASFIDKVRFL EQQNQVLQTK WELLQQVDTS TRTQNLDPFF ESYISNLRRQ 240
VDSLKNDQSR MDSELKNMQD LVEEYRTKYE DEINKRTNAE NEFVTIKKDV DSAYMNKAEL 300
QARVDNLQQD IDFFSTLYQM ELSQMQTQIS ETNVVLSMDN NRTLDLDGII AEVKAQYDSI 360
CQRSKAEAET FYQSKYEELQ ITAGKHGDSV KNTKMEISEL NRVIQRLRSE IDSVKKQISQ 420
MQQNISDAEQ RGEKALKDAQ NKLNEIEDAL TQAKEELTRL LRDYQELMNT KLALDMEIAT 480
YRKLLEGEEI RMSGECTPNV SVSVSTSHTS MSGTSSRGGG RYGSGGGGGG GTYGGGSRGG 540
SYGGGSGGGS YGGCSSGGGS GGGSYGGGSS GGHRGGSGGG GGSSGGSYGG SSGGGRGGSS 600
SGGGVKSSGS SSVKFVSTTY SRGTN 625 |
Gene Ontology | GO:0045095; C:keratin filament; IEA:Compara. GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. GO:0030246; F:carbohydrate binding; IEA:Compara. GO:0005198; F:structural molecule activity; IEA:InterPro. GO:0001867; P:complement activation, lectin pathway; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |