UniProt Accession

 BAX_HUMAN; Q07812; A8K4W1; P55269; Q07814; Q07815; Q8WZ49; Q9NR76; Q9NYG7; Q9UCZ6; Q9UCZ7; Q9UQD6 

Genbank Protein ID

 L22473; L22474; L22475; U19599; AF007826; AF247393; AJ417988; AF250190; AK291076; AY217036; CH471177; CH471177; BC014175 

Genbank Nucleotide ID

 AAA03619.1; AAA03620.1; AAA03621.1; AAC50142.1; AAD22706.1; AAF71267.1; CAD10744.1; AAF82094.1; BAF83765.1; AAO22992.1; EAW52418.1; EAW52417.1; AAH14175.1 

Protein Name

 Apoptosis regulator BAX 

Protein Synonyms/Alias

 Bcl-2-like protein 4; Bcl2-L-4 

Gene Name

 BAX 

Gene Synonyms/Alias

 BCL2L4 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
21	TSSEQIMKTGALLLQ	ubiquitination	[1, 2, 3]
57	VPQDASTKKLSECLK	ubiquitination	[2]
163	GGWVRLLKPPHPHHR	ubiquitination	[4]

Reference

 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis. 

Sequence Annotation

 MOTIF 59 73 BH3.
 MOTIF 98 118 BH1.
 MOTIF 150 165 BH2.
 MOD_RES 1 1 N-acetylmethionine.  

Keyword

 3D-structure; Acetylation; Alternative splicing; Apoptosis; Complete proteome; Cytoplasm; Host-virus interaction; Membrane; Mitochondrion; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix; Tumor suppressor. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 192 AA 

Protein Sequence

Gene Ontology

 GO:0097136; C:Bcl-2 family protein complex; IDA:UniProtKB.
 GO:0005829; C:cytosol; IDA:UniProtKB.
 GO:0005789; C:endoplasmic reticulum membrane; IDA:HGNC.
 GO:0005741; C:mitochondrial outer membrane; TAS:Reactome.
 GO:0005757; C:mitochondrial permeability transition pore complex; IDA:HGNC.
 GO:0005634; C:nucleus; IMP:UniProtKB.
 GO:0051434; F:BH3 domain binding; IDA:UniProtKB.
 GO:0015267; F:channel activity; IDA:BHF-UCL.
 GO:0008289; F:lipid binding; IDA:HGNC.
 GO:0042803; F:protein homodimerization activity; IDA:HGNC.
 GO:0008635; P:activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c; IDA:HGNC.
 GO:0006309; P:apoptotic DNA fragmentation; IMP:HGNC.
 GO:0001783; P:B cell apoptotic process; IDA:HGNC.
 GO:0001782; P:B cell homeostasis; IEA:Compara.
 GO:0002358; P:B cell homeostatic proliferation; IEA:Compara.
 GO:0002352; P:B cell negative selection; IEA:Compara.
 GO:0001974; P:blood vessel remodeling; IEA:Compara.
 GO:0071310; P:cellular response to organic substance; IEA:Compara.
 GO:0034644; P:cellular response to UV; IEA:Compara.
 GO:0021987; P:cerebral cortex development; IEA:Compara.
 GO:0006922; P:cleavage of lamin involved in execution phase of apoptosis; IMP:HGNC.
 GO:0045136; P:development of secondary sexual characteristics; IEA:Compara.
 GO:0010248; P:establishment or maintenance of transmembrane electrochemical gradient; IDA:HGNC.
 GO:0097191; P:extrinsic apoptotic signaling pathway; IDA:BHF-UCL.
 GO:0009566; P:fertilization; IEA:Compara.
 GO:0007281; P:germ cell development; IEA:Compara.
 GO:0035234; P:germ cell programmed cell death; IEA:Compara.
 GO:0006687; P:glycosphingolipid metabolic process; IEA:Compara.
 GO:0048873; P:homeostasis of number of cells within a tissue; IEA:Compara.
 GO:0021854; P:hypothalamus development; IEA:Compara.
 GO:0006917; P:induction of apoptosis; NAS:UniProtKB.
 GO:0070059; P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; IMP:UniProtKB.
 GO:0001822; P:kidney development; IEA:Compara.
 GO:0035108; P:limb morphogenesis; IEA:Compara.
 GO:0043653; P:mitochondrial fragmentation involved in apoptotic process; IDA:HGNC.
 GO:0008053; P:mitochondrial fusion; IDA:HGNC.
 GO:0002262; P:myeloid cell homeostasis; IEA:Compara.
 GO:0048147; P:negative regulation of fibroblast proliferation; IEA:Compara.
 GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Compara.
 GO:0033137; P:negative regulation of peptidyl-serine phosphorylation; IEA:Compara.
 GO:0032091; P:negative regulation of protein binding; IDA:UniProtKB.
 GO:0051402; P:neuron apoptotic process; IEA:Compara.
 GO:0001764; P:neuron migration; IEA:Compara.
 GO:0030264; P:nuclear fragmentation involved in apoptotic nuclear change; IMP:HGNC.
 GO:0042475; P:odontogenesis of dentin-containing tooth; IEA:Compara.
 GO:0001541; P:ovarian follicle development; IEA:Compara.
 GO:0060058; P:positive regulation of apoptotic process involved in mammary gland involution; IEA:Compara.
 GO:0002904; P:positive regulation of B cell apoptotic process; IEA:Compara.
 GO:0048087; P:positive regulation of developmental pigmentation; IEA:Compara.
 GO:1900103; P:positive regulation of endoplasmic reticulum unfolded protein response; IMP:UniProtKB.
 GO:2001244; P:positive regulation of intrinsic apoptotic signaling pathway; IMP:UniProtKB.
 GO:1901030; P:positive regulation of mitochondrial outer membrane permeabilization; TAS:Reactome.
 GO:0043525; P:positive regulation of neuron apoptotic process; IDA:HGNC.
 GO:0032461; P:positive regulation of protein oligomerization; IDA:UniProtKB.
 GO:0090200; P:positive regulation of release of cytochrome c from mitochondria; IDA:UniProtKB.
 GO:0051281; P:positive regulation of release of sequestered calcium ion into cytosol; IEA:Compara.
 GO:0048597; P:post-embryonic camera-type eye morphogenesis; IEA:Compara.
 GO:0051260; P:protein homooligomerization; IDA:HGNC.
 GO:0001844; P:protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; IEA:Compara.
 GO:0032471; P:reduction of endoplasmic reticulum calcium ion concentration; IEA:Compara.
 GO:0051726; P:regulation of cell cycle; IEA:Compara.
 GO:0033599; P:regulation of mammary gland epithelial cell proliferation; IEA:Compara.
 GO:0051881; P:regulation of mitochondrial membrane potential; IDA:HGNC.
 GO:0006808; P:regulation of nitrogen utilization; IEA:Compara.
 GO:0043497; P:regulation of protein heterodimerization activity; IPI:HGNC.
 GO:0043496; P:regulation of protein homodimerization activity; IDA:HGNC.
 GO:0001836; P:release of cytochrome c from mitochondria; IDA:HGNC.
 GO:0032976; P:release of matrix enzymes from mitochondria; IDA:HGNC.
 GO:0001101; P:response to acid; IEA:Compara.
 GO:0048678; P:response to axon injury; IEA:Compara.
 GO:0006974; P:response to DNA damage stimulus; IEA:Compara.
 GO:0010332; P:response to gamma radiation; IEA:Compara.
 GO:0009651; P:response to salt stress; IEA:Compara.
 GO:0009636; P:response to toxic substance; IDA:HGNC.
 GO:0060041; P:retina development in camera-type eye; IEA:Compara.
 GO:1990009; P:retinal cell apoptotic process; IMP:HGNC.
 GO:0046666; P:retinal cell programmed cell death; IEA:Compara.
 GO:0060011; P:Sertoli cell proliferation; IEA:Compara.
 GO:0048515; P:spermatid differentiation; IEA:Compara.
 GO:0001777; P:T cell homeostatic proliferation; IEA:Compara.
 GO:0006927; P:transformed cell apoptotic process; IMP:HGNC.
 GO:0060068; P:vagina development; IEA:Compara.
 GO:0019048; P:virus-host interaction; IEA:UniProtKB-KW. 

Interpro

 IPR026304; BAX.
 IPR002475; Bcl2-like.
 IPR020717; Bcl2_BH1_motif_CS.
 IPR020726; Bcl2_BH2_motif_CS.
 IPR020728; Bcl2_BH3_motif_CS.
 IPR026298; Blc2_fam. 

Pfam

 PF00452; Bcl-2 

SMART

  

PROSITE

 PS50062; BCL2_FAMILY
 PS01080; BH1
 PS01258; BH2
 PS01259; BH3 

PRINTS

 PR01862; BCL2FAMILY.