CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011469
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Transcription factor SOX-4 
Protein Synonyms/Alias
  
Gene Name
 SOX4 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
53ADDPSWCKTPSGHIKubiquitination[1]
101GKRWKLLKDSDKIPFubiquitination[1]
118EAERLRLKHMADYPDubiquitination[1]
154ASSKPGEKGDKVGGSacetylation[2]
202QKKSCGSKVAGGAGGubiquitination[1]
213GAGGGVSKPHAKLILacetylation[2]
213GAGGGVSKPHAKLILubiquitination[1]
217GVSKPHAKLILAGGGacetylation[2]
217GVSKPHAKLILAGGGubiquitination[1]
261ADHHSLYKARTPSASubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
 Transcriptional activator that binds with high affinity to the T-cell enhancer motif 5'-AACAAAG-3' motif. 
Sequence Annotation
 DNA_BIND 59 127 HMG box.
 MOD_RES 276 276 Phosphoserine (By similarity).  
Keyword
 Activator; Complete proteome; DNA-binding; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 474 AA 
Protein Sequence
MVQQTNNAEN TEALLAGESS DSGAGLELGI ASSPTPGSTA STGGKADDPS WCKTPSGHIK 60
RPMNAFMVWS QIERRKIMEQ SPDMHNAEIS KRLGKRWKLL KDSDKIPFIR EAERLRLKHM 120
ADYPDYKYRP RKKVKSGNAN SSSSAAASSK PGEKGDKVGG SGGGGHGGGG GGGSSNAGGG 180
GGGASGGGAN SKPAQKKSCG SKVAGGAGGG VSKPHAKLIL AGGGGGGKAA AAAAASFAAE 240
QAGAAALLPL GAAADHHSLY KARTPSASAS ASSAASASAA LAAPGKHLAE KKVKRVYLFG 300
GLGTSSSPVG GVGAGADPSD PLGLYEEEGA GCSPDAPSLS GRSSAASSPA AGRSPADHRG 360
YASLRAASPA PSSAPSHASS SASSHSSSSS SSGSSSSDDE FEDDLLDLNP SSNFESMSLG 420
SFSSSSALDR DLDFNFEPGS GSHFEFPDYC TPEVSEMISG DWLESSISNL VFTY 474 
Gene Ontology
 GO:0005739; C:mitochondrion; IDA:HPA.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0001046; F:core promoter sequence-specific DNA binding; IDA:UniProtKB.
 GO:0001077; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; IDA:UniProtKB.
 GO:0001105; F:RNA polymerase II transcription coactivator activity; ISS:UniProtKB.
 GO:0035910; P:ascending aorta morphogenesis; ISS:BHF-UCL.
 GO:0003289; P:atrial septum primum morphogenesis; ISS:BHF-UCL.
 GO:0060070; P:canonical Wnt receptor signaling pathway; ISS:BHF-UCL.
 GO:0003215; P:cardiac right ventricle morphogenesis; ISS:BHF-UCL.
 GO:0003211; P:cardiac ventricle formation; ISS:UniProtKB.
 GO:0071333; P:cellular response to glucose stimulus; ISS:UniProtKB.
 GO:0042769; P:DNA damage response, detection of DNA damage; IDA:UniProtKB.
 GO:0006977; P:DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; IMP:UniProtKB.
 GO:0031018; P:endocrine pancreas development; IEA:Compara.
 GO:0021782; P:glial cell development; ISS:UniProtKB.
 GO:0014009; P:glial cell proliferation; ISS:UniProtKB.
 GO:0060993; P:kidney morphogenesis; ISS:BHF-UCL.
 GO:0060174; P:limb bud formation; ISS:UniProtKB.
 GO:0003183; P:mitral valve morphogenesis; ISS:BHF-UCL.
 GO:0043066; P:negative regulation of apoptotic process; IMP:BHF-UCL.
 GO:0008285; P:negative regulation of cell proliferation; IMP:UniProtKB.
 GO:0046826; P:negative regulation of protein export from nucleus; IMP:UniProtKB.
 GO:0031397; P:negative regulation of protein ubiquitination; IMP:UniProtKB.
 GO:0001841; P:neural tube formation; ISS:UniProtKB.
 GO:0060563; P:neuroepithelial cell differentiation; ISS:UniProtKB.
 GO:0003357; P:noradrenergic neuron differentiation; ISS:UniProtKB.
 GO:0043065; P:positive regulation of apoptotic process; IMP:UniProtKB.
 GO:0090263; P:positive regulation of canonical Wnt receptor signaling pathway; ISS:UniProtKB.
 GO:0008284; P:positive regulation of cell proliferation; IMP:BHF-UCL.
 GO:0032024; P:positive regulation of insulin secretion; ISS:UniProtKB.
 GO:2000761; P:positive regulation of N-terminal peptidyl-lysine acetylation; IDA:UniProtKB.
 GO:0045727; P:positive regulation of translation; IMP:UniProtKB.
 GO:0002328; P:pro-B cell differentiation; ISS:BHF-UCL.
 GO:0050821; P:protein stabilization; IMP:BHF-UCL.
 GO:0001501; P:skeletal system development; ISS:UniProtKB.
 GO:0035019; P:somatic stem cell maintenance; IEA:Compara.
 GO:0021522; P:spinal cord motor neuron differentiation; ISS:UniProtKB.
 GO:0048485; P:sympathetic nervous system development; ISS:UniProtKB.
 GO:0030217; P:T cell differentiation; ISS:BHF-UCL.
 GO:0006927; P:transformed cell apoptotic process; IMP:BHF-UCL.
 GO:0060412; P:ventricular septum morphogenesis; ISS:BHF-UCL. 
Interpro
 IPR009071; HMG_box_dom.
 IPR017386; SOX-12/11/4a. 
Pfam
 PF00505; HMG_box 
SMART
 SM00398; HMG 
PROSITE
 PS50118; HMG_BOX_2 
PRINTS