CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014200
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cyclin-dependent kinase-like 2 
Protein Synonyms/Alias
  
Gene Name
 Cdkl2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
46DDDKMVKKIAMREIKacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
 DOMAIN 4 289 Protein kinase.
 NP_BIND 10 18 ATP (By similarity).
 MOTIF 45 51 [NKR]KIAxRE.
 ACT_SITE 126 126 Proton acceptor (By similarity).
 BINDING 33 33 ATP (By similarity).  
Keyword
 ATP-binding; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding; Nucleus; Reference proteome; Serine/threonine-protein kinase; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 507 AA 
Protein Sequence
MEKYENLGLV GEGSYGMVMK CRNKDSGRIV AIKKFLESDD DKMVKKIAMR EIKLLKQLRH 60
ENLVNLLEVC KKKKRWYLVF EFVDHTILDD LKLFPNGLDY QVVQKYLFQI INGIGFCHSH 120
NIIHRDIKPE NILVSQSGVV KLCDFGFART LAAPGEVYTD YVATRWYRAP ELLVGDVKYG 180
KAVDIWAIGC LVIEMLMGQP LFPGESDIDQ LHHIMTCLGN LIPRHQELFY KNPVFAGVRL 240
PEIKDIEAEP LESRYPKLPE VVISLAKKCL HIDPDKRPLC ADLLHHDFFQ MDGFAERFSQ 300
ELQLKIEKDA RNNSLPKKFQ IRKKEKDDAL GEERKTLVVQ DTNADPKTKD SKVLKVKGSK 360
IDVEKTEKGT RASNGSCLHD NGTSHKGLSS TSLRDCSNVT IDHPRNPGTA IPPLTHNLSA 420
VAPGINAAMG TIPGVQNYRV DEKTKKYCNP FVKPSQPSPS GIYNMNVSAS VSNCPLPRKS 480
KHSPPLDLAV SMGARRVKLY LETESET 507 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004693; F:cyclin-dependent protein serine/threonine kinase activity; IEA:EC. 
Interpro
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR002290; Ser/Thr_dual-sp_kinase_dom.
 IPR008271; Ser/Thr_kinase_AS. 
Pfam
 PF00069; Pkinase 
SMART
 SM00220; S_TKc 
PROSITE
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 
PRINTS