CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013119
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Glycerol-3-phosphate dehydrogenase 1-like protein 
Protein Synonyms/Alias
  
Gene Name
 Gpd1l 
Gene Synonyms/Alias
 Kiaa0089 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
29KIIGSNVKTLQKFSSubiquitination[1]
180MQNGLLFKELLQTPNubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Plays a role in regulating cardiac sodium current; decreased enzymatic activity with resulting increased levels of glycerol 3-phosphate activating the DPD1L-dependent SCN5A phosphorylation pathway, may ultimately lead to decreased sodium current; cardiac sodium current may also be reduced due to alterations of NAD(H) balance induced by DPD1L (By similarity). 
Sequence Annotation
 NP_BIND 12 17 NAD (By similarity).
 REGION 271 272 Substrate binding (By similarity).
 ACT_SITE 206 206 Proton acceptor (By similarity).
 BINDING 43 43 NAD (By similarity).
 BINDING 99 99 NAD (By similarity).
 BINDING 122 122 Substrate (By similarity).
 BINDING 155 155 NAD; via amide nitrogen (By similarity).
 BINDING 271 271 NAD (By similarity).
 BINDING 298 298 NAD; via amide nitrogen (By similarity).
 BINDING 300 300 NAD (By similarity).  
Keyword
 Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; NAD; Oxidoreductase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 351 AA 
Protein Sequence
MAAAPLKVCI VGSGNWGSAV AKIIGSNVKT LQKFSSTVKM WVFEETVNGR KLTDIINNDH 60
ENVKYLPGHK LPENVVAVPN LSEAVQDADL LVFVIPHQFI HKICDEITGR VPEKALGITL 120
IKGIDEGPDG LKLISDIIRE KMGIDISVLM GANIASEVAA EKFCETTIGS KVMQNGLLFK 180
ELLQTPNFRI TVVDDADTVE LCGALKNIVA VGAGFCDGLR CGDNTKAAVI RLGLMEMIAF 240
AKIFCKGQVS TATFLESCGV ADLITTCYGG RNRRVAEAFA RTGKTIEELE KELLNGQKLQ 300
GPQTSAEVYR ILRQKGLLDK FPLFTAVYQI CYEGRPVTQM LSCLQSHPEH I 351 
Gene Ontology
 GO:0009331; C:glycerol-3-phosphate dehydrogenase complex; IEA:InterPro.
 GO:0016020; C:membrane; IDA:BHF-UCL.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0004367; F:glycerol-3-phosphate dehydrogenase [NAD+] activity; IEA:EC.
 GO:0051287; F:NAD binding; IEA:InterPro.
 GO:0017080; F:sodium channel regulator activity; IEA:Compara.
 GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
 GO:0046168; P:glycerol-3-phosphate catabolic process; IEA:InterPro.
 GO:0006734; P:NADH metabolic process; IMP:MGI.
 GO:0033137; P:negative regulation of peptidyl-serine phosphorylation; IEA:Compara.
 GO:0090038; P:negative regulation of protein kinase C signaling cascade; IEA:Compara.
 GO:2000010; P:positive regulation of protein localization to cell surface; IEA:Compara.
 GO:0010765; P:positive regulation of sodium ion transport; IEA:Compara.
 GO:0002027; P:regulation of heart rate; IEA:Compara.
 GO:2000649; P:regulation of sodium ion transmembrane transporter activity; IEA:Compara.
 GO:0086005; P:regulation of ventricular cardiac muscle cell action potential; IEA:Compara.
 GO:0060373; P:regulation of ventricular cardiac muscle cell membrane depolarization; IEA:Compara. 
Interpro
 IPR008927; 6-PGluconate_DH_C-like.
 IPR013328; DH_multihelical.
 IPR006168; G3P_DH_NAD-dep.
 IPR006109; G3P_DH_NAD-dep_C.
 IPR017751; G3P_DH_NAD-dep_euk.
 IPR011128; G3P_DH_NAD-dep_N.
 IPR016040; NAD(P)-bd_dom. 
Pfam
 PF07479; NAD_Gly3P_dh_C
 PF01210; NAD_Gly3P_dh_N 
SMART
  
PROSITE
 PS00957; NAD_G3PDH 
PRINTS
 PR00077; GPDHDRGNASE.