CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-035814
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Kalirin 
Protein Synonyms/Alias
  
Gene Name
 Kalrn 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
1969KPIQRITKYQLLLKDacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome; Repeat; SH3 domain. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2308 AA 
Protein Sequence
EDVCKRGFTV IIDMRGSKWD LIKPLLKTLQ EAFPAEIHVA LIIKPDNFWQ KQKTNFGSSK 60
FIFETSMVSV EGLTKLVDPS QLTEEFDGSL DYNHEEWIEL RLSLEEFFNS AVHLLSRLED 120
LQEMLARKEF PVDVEGSRRL IDEHTQLKKK VLKAPVEELD REGQRLLQCI RCSDGFSGRN 180
CIPGSADFQS LVPKITSLLD KLHSTRQHLH QMWHVRKLKL DQCFQLRLFE QDAEKMFDWI 240
SHNKELFLQS HTEIGVSYQH ALDLQTQHNH FAMNSMNAYV NINRIMSVAS RLSEAGHYAS 300
QQIKQISTQL DQEWKSFAAA LDERSTILAM SAVFHQKAEQ FLSGVDAWCK MCSEGGLPSE 360
MQDLELAIHH HQSLYEQVTQ AYTEVSQDGK ALLDVLQRPL SPGNSESLTA TANYSKAVHQ 420
VLDVVHEVLH HQRRLESIWQ HRKVRLHQRL QLCVFQQDVQ QVLDWIENHG EAFLSKHTGV 480
GKSLHRARAL QKRHDDFEEV AQNTYTNADK LLEAAEQLAQ TGECDPEEIY KAARHLEVRI 540
QDFVRRVEQR KLLLDMSVSF HTHTKELWTW MEDLQKEVLE DVCADSVDAV QELIKQFQQQ 600
QTATLDATLN VIKEGEDLIQ QLRSAPPSLG EPTEARDSAV SNNKTPHSSS ISHIESVLQQ 660
LDDAQVQMEE LFHERKIKLD IFLQLRIFEQ YTIEVTAELD AWNEDLLRQM NDFNTEDLTL 720
AEQRLQRHTE RKLAMNNMTF EVIQQGQDLH QYIMEVQASG IELICEKDVD LAAQVQELLE 780
FLHEKQHELE LNAEQTHKRL EQCLQLRHLQ AEVKQVLGWI RNGESMLNAS LVNASSLSEA 840
EQLQREHEQF QLAIEKTHQS ALQVQQKAEA LLQAGHYDAD AIRECAEKVA LHWQQLMLKM 900
EDRLKLVNAS VAFYKTSEQV CSVLESLEQE YRRDEDWCGG RDKLGPAAEM DHVIPLLSKH 960
LEQKEAFLKA CTLARRNAEV FLKYIHRNNV SMPSVASHTR GPEQQVKAIL SELLQRENRV 1020
LHFWTLKKRR LDQCQQYVVF ERSAKQALDW IQETGEYYLS THTSTGETTE ETQELLKEYG 1080
EFRVPAKQTK EKVKLLIQLA DSFVEKGHIH ATEIRKWVTT VDKHYRDFSL RMGKYRYTLE 1140
KALGVNTEDN KDLELDIIPA SLSDREVKLR DANHEVNEEK RKSARKKEFI MAELLQTEKA 1200
YVRDLHECLE TYLWEMTSGV EEIPPGILNK EHIIFGNIQE IYDFHNNIFL KELEKYEQLP 1260
EDVGHCFVTW ADKFQMYVTY CKNKPDSNQL ILEHAGTFFD EIQQRHGLAN SISSYLIKPV 1320
QRVTKYQLLL KELLTCCEEG KGELKDGLEV MLSVPKKAND AMHVSMLEGF DENLDVQGEL 1380
ILQDAFQVWD PKSLIRKGRE RHLFLFEISL VFSKEIKDSS GHTKYVYKNK LLTSELGVTE 1440
HVEGDPCKFA LWSGRTPSSD NKTVLKASNI ETKQEWIKNI REVIQERIIH LKGALKEPIQ 1500
LPKTPAKLRN NSKRDGVEDG DSQGDGSSQP DTISIASRTS QNTVESDKLS GGCELTVVLQ 1560
DFSAAHSSEL SIQVGQTVEL LERPSERPGW CLVRTTERSP PQEGLVPSST LCISHSRSSV 1620
EMDCFFPLVK DSYSHSSGEN GGKSESVANL QSQPSLNSIH SSPGPKRSTN TLKKWLTSPV 1680
RRLNSGKADG NIKKQKKVRD GRKSFDLGSP KPGDETTPQG DSADEKSKKG WGEDEPDEES 1740
HTPLPPPMKI FDNDPTQDEM SSLLAARQAP TDVPTAADLV SAIEKLVKSK LTLEGGSYRG 1800
SLKDPTVCLN EGMAPPTPPR NLEEEQKAKA LRGRMFVLNE LVQTEKDYVK DLGIVVEGFM 1860
KRIEEKGVPE DMRGKEKIVF GNIHQIYDWH KDFFLAELEK CIQEQDRLAQ LFIKHERKLH 1920
IYVWYCQNKP RSEYIVAEYD AYFEEVKQEI NQRLTLSDFL IKPIQRITKY QLLLKDFLRY 1980
SEKAGLECSD IEKAVELMCL VPKRCNDMMN LGRLQGFEGT LTAQGKLLQQ DTFYVIELDA 2040
GMQSRTKERR VFLFEQIVIF SELLRKGSLT PGYMFKRSIK MNYLVLEEDV DDDPCKFALM 2100
NRETSERVIL QAANPDIQQA WVQDINQVLE TQRDFLNALQ SPIEYQRKER STAVIRSQPP 2160
RVPQASPRPY SSVPVGSEKP PKGSSYNPPL PPLKISTSNG SPGFDYHQPG DKFDASKQND 2220
LGGCNGTSTM AVIKDYYALK ENEICVSQGE VVQVLAVNQQ NMCLVYQPAS DHSPAAEGWV 2280
PGSILAPLTK ATAPAESSDE SIKTLLLP 2308 
Gene Ontology
 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0005543; F:phospholipid binding; IEA:InterPro.
 GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
 GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. 
Interpro
 IPR001251; CRAL-TRIO_dom.
 IPR000219; DH-domain.
 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology.
 IPR001452; SH3_domain.
 IPR018159; Spectrin/alpha-actinin.
 IPR002017; Spectrin_repeat. 
Pfam
 PF00621; RhoGEF
 PF00018; SH3_1
 PF00435; Spectrin 
SMART
 SM00233; PH
 SM00325; RhoGEF
 SM00326; SH3
 SM00150; SPEC 
PROSITE
 PS50191; CRAL_TRIO
 PS50010; DH_2
 PS50003; PH_DOMAIN
 PS50002; SH3 
PRINTS