CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-028647
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 MAP kinase-activating death domain protein 
Protein Synonyms/Alias
  
Gene Name
 Madd 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
540RQTPFAEKLARTQAVubiquitination[1]
981LRVFVLSKLNRAVQSubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1577 AA 
Protein Sequence
MVQKKFCPRL LDYLVIVGAR HPSSDSVAQT PELLRRYPLE DHPEFPLPPD VVFFCQPEGC 60
LSVRQRRMSL RDDTSFVFTL TDKDTGVTRY GICVNFYRSF QKRMPKEKVE GGAGPRGKEG 120
AHTSGASEEA AAGSSESGST LQPPSADSTP DVNQSPRGKR RAKAGSRSRN STLTSLCVLS 180
HYPFFSTFRE CLYTLKRLVD CCSERLLGKK LGIPRGVQRD TMWRIFTGSL LVEEKSSALL 240
QDLREIEAWI YRLLRSPVPV SGQKRVDIEV LPQELQQALT FALPDPSRFT LVDFPLHLPL 300
ELLGVDACLQ VLTCILLEHK VVLQSRDYNA LSMSVMAFVA MIYPLEYMFP VIPLLPTCMA 360
SAEQLLLAPT PYIIGVPASF FLYKLDFKMP DDVWLVDLDS NRVIAPTNAE VLPILPEPES 420
LELKKHLKQA LASMSLNTQP ILNLEKFHEG QEIPLLLGRP SNDLQSTPST EFNPLIYGND 480
VDSVDVATRV AMVRFFNSAN VLQGFQMHTR TLRLFPRPVV AFQAGSFLAS RPRQTPFAEK 540
LARTQAVEYF GEWILNPSNY AFQRIHNNTF DPALIGDKPK WYAHQLQPIH YRVYDGNSQL 600
AEALSVPPER DSDSDPTEDS GSDSQDYDDS SSSYSSLGDF VSEMMKCDIN GDTPNVDPLT 660
HAALGDASEV EIDELQPQKE GEEPGPDSEN SQENPPLRSS SSTTASSSPS TVVHSAHSEA 720
ADSTEMGDKA TAGISKPLPP VPPSICKSTV DRRQTETGEG SVCQRTYDNP YFEPQYGFPP 780
EEDEEEQGES YTPRFSQHVS GSRAQKLLRP NSLKLASDSD AESDSRASSP NSTVSNNSTE 840
GFGGIMSFAS SLYRNHSTSF SLSNLTLPTK GAREKTTPFP SLKVFGLNTL MEIVTEAGPG 900
SGEGNRRALV DQKSSVIKHS PTVKREPSSP QGRSSNSSEN QQFLKEVVHS VLDGQGVGWL 960
NMKKVRRLLE SEQLRVFVLS KLNRAVQSED DARQDVIQDV EISRKVYKGM LDLLKCTVLS 1020
LEQSYAHAGL GGMASIFGLL EIAQTHYYSK EPDKRKRSPT ENVNTPVGKD PGLAGRGDPK 1080
AMAQLRVPQL GPRAPSATGK GPKELDTRSL KEENFVASVE LWNKHQEVKK QKALEKQRPE 1140
GIKPVFDLGE TEEKKSQMSA DSGVSLTSAS QRTDQDSVIG VSPAVMIRSS SQDSEVSTVS 1200
NSSGETLGAD SDLSSNAGDG PGGEGSAHLA SSRATLSDSE IETNSATSAI FGKAHSLKPK 1260
EKPAGSPIRS SEDVSQRVYL YEGLLGRDKG SMWDQLEDAA METFSLSKER STLWDQMQFW 1320
EDAFLDAVML EREGMGMDQG PQEMIDRYLS LGEHDRKRLE DDEDRLLATL LHNLISYMLL 1380
MKVNKNDIRK KVRRLMGKSH IGLVYSQQVN EVLDQLNSLN GRDLSIRSSG SRHMKKQTFV 1440
VHAGTDTNGD IFFMEVCDDC VVLRSNIGTV YERWWYEKLI NMTYCPKTKV LCLWRRNGSE 1500
TQLNKFYTKK CRELYYCVKD SMERAAARQQ SIKPGPELGG EFPVQDMKTG EGGLLQVTLE 1560
GINLKFMHNQ FLKLKKW 1577 
Gene Ontology
 GO:2001234; P:negative regulation of apoptotic signaling pathway; IMP:MGI. 
Interpro
 IPR005112; dDENN_dom.
 IPR001194; DENN_dom.
 IPR005113; uDENN_dom. 
Pfam
 PF03455; dDENN
 PF02141; DENN
 PF03456; uDENN 
SMART
 SM00801; dDENN
 SM00799; DENN
 SM00800; uDENN 
PROSITE
 PS50947; DDENN
 PS50211; DENN
 PS50946; UDENN 
PRINTS