| Tag | Content |
|---|
| CPLM ID | CPLM-007555 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Rho GTPase-activating protein 25 |
Protein Synonyms/Alias | Rho-type GTPase-activating protein 25 |
Gene Name | ARHGAP25 |
Gene Synonyms/Alias | KIAA0053 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 4 | ****MSLKLPRNWDF | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state (By similarity). |
Sequence Annotation | DOMAIN 46 151 PH.
DOMAIN 159 353 Rho-GAP.
MOD_RES 362 362 Phosphoserine (By similarity).
MOD_RES 395 395 Phosphoserine.
MOD_RES 407 407 Phosphoserine (By similarity). |
Keyword | 3D-structure; Alternative splicing; Coiled coil; Complete proteome; GTPase activation; Phosphoprotein; Polymorphism; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 645 AA |
Protein Sequence | MSLKLPRNWD FNLKVEAAKI ARSRSVMTGE QMAAFHPSST PNPLERPIKM GWLKKQRSIV 60
KNWQQRYFVL RAQQLYYYKD EEDTKPQGCM YLPGCTIKEI ATNPEEAGKF VFEIIPASWD 120
QNRMGQDSYV LMASSQAEME EWVKFLRRVA GTPCGAVFGQ RLDETVAYEQ KFGPHLVPIL 180
VEKCAEFILE HGRNEEGIFR LPGQDNLVKQ LRDAFDAGER PSFDRDTDVH TVASLLKLYL 240
RDLPEPVVPW SQYEGFLLCG QLTNADEAKA QQELMKQLSI LPRDNYSLLS YICRFLHEIQ 300
LNCAVNKMSV DNLATVIGVN LIRSKVEDPA VIMRGTPQIQ RVMTMMIRDH EVLFPKSKDI 360
PLSPPAQKND PKKAPVARSS VGWDATEDLR ISRTDSFSSM TSDSDTTSPT GQQPSDAFPE 420
DSSKVPREKP GDWKMQSRKR TQTLPNRKCF LTSAFQGANS SKMEIFKNEF WSPSSEAKAG 480
EGHRRTMSQD LRQLSDSQRT STYDNVPSLP GSPGEEASAL SSQACDSKGD TLASPNSETG 540
PGKKNSGEEE IDSLQRMVQE LRKEIETQKQ MYEEQIKNLE KENYDVWAKV VRLNEELEKE 600
KKKSAALEIS LRNMERSRED VEKRNKALEE EVKEFVKSMK EPKTEA 646 |
Gene Ontology | GO:0005829; C:cytosol; TAS:Reactome. GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW. GO:0005543; F:phospholipid binding; IEA:InterPro. GO:0043547; P:positive regulation of GTPase activity; IEA:GOC. GO:0051056; P:regulation of small GTPase mediated signal transduction; TAS:Reactome. GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |