UniProt Accession

 EDIL3_HUMAN; O43854; B2R763; O43855; Q5D094 

Genbank Protein ID

 U70312; U70313; AK312858; CH471084; CH471084; BC053656 

Genbank Nucleotide ID

 AAC02648.1; AAC02649.1; BAG35710.1; EAW95917.1; EAW95918.1; AAH53656.1 

Protein Name

 EGF-like repeat and discoidin I-like domain-containing protein 3 

Protein Synonyms/Alias

 Developmentally-regulated endothelial cell locus 1 protein; Integrin-binding protein DEL1 

Gene Name

 EDIL3 

Gene Synonyms/Alias

 DEL1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
244	IGSPEYIKSYKIAYS	ubiquitination	[1, 2, 3]
255	IAYSNDGKTWAMYKV	ubiquitination	[2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Promotes adhesion of endothelial cells through interaction with the alpha-v/beta-3 integrin receptor. Inhibits formation of vascular-like structures. May be involved in regulation of vascular morphogenesis of remodeling in embryonic development. 

Sequence Annotation

 DOMAIN 22 60 EGF-like 1.
 DOMAIN 74 117 EGF-like 2.
 DOMAIN 119 155 EGF-like 3.
 DOMAIN 158 314 F5/8 type C 1.
 DOMAIN 319 476 F5/8 type C 2.
 MOTIF 96 98 Cell attachment site (Potential).
 DISULFID 26 37 By similarity.
 DISULFID 31 48 By similarity.
 DISULFID 50 59 By similarity.
 DISULFID 78 89 By similarity.
 DISULFID 83 105 By similarity.
 DISULFID 107 116 By similarity.
 DISULFID 123 134 By similarity.
 DISULFID 128 143 By similarity.
 DISULFID 145 154 By similarity.
 DISULFID 158 314 By similarity.
 DISULFID 301 305 By similarity.
 DISULFID 319 476 By similarity.  

Keyword

 3D-structure; Alternative splicing; Cell adhesion; Complete proteome; Developmental protein; Disulfide bond; EGF-like domain; Reference proteome; Repeat; Secreted; Signal. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 480 AA 

Protein Sequence

Gene Ontology

 GO:0070062; C:extracellular vesicular exosome; IDA:UniProtKB.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0005178; F:integrin binding; TAS:ProtInc.
 GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
 GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.
 GO:0010811; P:positive regulation of cell-substrate adhesion; IEA:Compara. 

Interpro

 IPR000421; Coagulation_fac_5/8-C_type_dom.
 IPR000742; EG-like_dom.
 IPR001881; EGF-like_Ca-bd.
 IPR013032; EGF-like_CS.
 IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
 IPR018097; EGF_Ca-bd_CS.
 IPR008979; Galactose-bd-like. 

Pfam

 PF00008; EGF
 PF00754; F5_F8_type_C 

SMART

 SM00181; EGF
 SM00179; EGF_CA
 SM00231; FA58C 

PROSITE

 PS00010; ASX_HYDROXYL
 PS00022; EGF_1
 PS01186; EGF_2
 PS50026; EGF_3
 PS01187; EGF_CA
 PS01285; FA58C_1
 PS01286; FA58C_2
 PS50022; FA58C_3 

PRINTS