CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015472
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 PERQ amino acid-rich with GYF domain-containing protein 2 
Protein Synonyms/Alias
 GRB10-interacting GYF protein 2; Trinucleotide repeat-containing gene 15 protein 
Gene Name
 GIGYF2 
Gene Synonyms/Alias
 KIAA0642; PERQ2; TNRC15 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
57ALFLKDNKIPSDLLDubiquitination[1]
515DDERLASKLQEHRAKubiquitination[1]
667LQQFQTLKMRISDQNubiquitination[1]
973RQQRELMKALQQQQQubiquitination[2]
994SGWGNVSKPSGTTKSubiquitination[2]
1015EEARQMQKQQQQQQQubiquitination[1]
1084GFWDDAVKEVGPRNSubiquitination[1]
1123EEEEKLLKLFQGVNKubiquitination[2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 
Functional Description
 May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling, including IGF1 and insulin receptors. 
Sequence Annotation
 DOMAIN 533 581 GYF.
 REGION 547 563 Required for GRB10-binding (By
 MOD_RES 25 25 Phosphothreonine (By similarity).
 MOD_RES 26 26 Phosphoserine.
 MOD_RES 30 30 Phosphoserine.
 MOD_RES 139 139 Phosphoserine.
 MOD_RES 160 160 Phosphoserine.
 MOD_RES 189 189 Phosphoserine.
 MOD_RES 236 236 Phosphoserine.
 MOD_RES 382 382 Phosphothreonine.
 MOD_RES 593 593 Phosphoserine.  
Keyword
 Alternative splicing; Complete proteome; Disease mutation; Neurodegeneration; Parkinson disease; Parkinsonism; Phosphoprotein; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1299 AA 
Protein Sequence
MAAETQTLNF GPEWLRALSS GGSITSPPLS PALPKYKLAD YRYGREEMLA LFLKDNKIPS 60
DLLDKEFLPI LQEEPLPPLA LVPFTEEEQR NFSMSVNSAA VLRLTGRGGG GTVVGAPRGR 120
SSSRGRGRGR GECGFYQRSF DEVEGVFGRG GGREMHRSQS WEERGDRRFE KPGRKDVGRP 180
NFEEGGPTSV GRKHEFIRSE SENWRIFREE QNGEDEDGGW RLAGSRRDGE RWRPHSPDGP 240
RSAGWREHME RRRRFEFDFR DRDDERGYRR VRSGSGSIDD DRDSLPEWCL EDAEEEMGTF 300
DSSGAFLSLK KVQKEPIPEE QEMDFRPVDE GEECSDSEGS HNEEAKEPDK TNKKEGEKTD 360
RVGVEASEET PQTSSSSARP GTPSDHQSQE ASQFERKDEP KTEQTEKAEE ETRMENSLPA 420
KVPSRGDEMV ADVQQPLSQI PSDTASPLLI LPPPVPNPSP TLRPVETPVV GAPGMGSVST 480
EPDDEEGLKH LEQQAEKMVA YLQDSALDDE RLASKLQEHR AKGVSIPLMH EAMQKWYYKD 540
PQGEIQGPFN NQEMAEWFQA GYFTMSLLVK RACDESFQPL GDIMKMWGRV PFSPGPAPPP 600
HMGELDQERL TRQQELTALY QMQHLQYQQF LIQQQYAQVL AQQQKAALSS QQQQQLALLL 660
QQFQTLKMRI SDQNIIPSVT RSVSVPDTGS IWELQPTASQ PTVWEGGSVW DLPLDTTTPG 720
PALEQLQQLE KAKAAKLEQE RREAEMRAKR EEEERKRQEE LRRQQEEILR RQQEEERKRR 780
EEEELARRKQ EEALRRQREQ EIALRRQREE EERQQQEEAL RRLEERRREE EERRKQEELL 840
RKQEEEAAKW AREEEEAQRR LEENRLRMEE EAARLRHEEE ERKRKELEVQ RQKELMRQRQ 900
QQQEALRRLQ QQQQQQQLAQ MKLPSSSTWG QQSNTTACQS QATLSLAEIQ KLEEERERQL 960
REEQRRQQRE LMKALQQQQQ QQQQKLSGWG NVSKPSGTTK SLLEIQQEEA RQMQKQQQQQ 1020
QQHQQPNRAR NNTHSNLHTS IGNSVWGSIN TGPPNQWASD LVSSIWSNAD TKNSNMGFWD 1080
DAVKEVGPRN STNKNKNNAS LSKSVGVSNR QNKKVEEEEK LLKLFQGVNK AQDGFTQWCE 1140
QMLHALNTAN NLDVPTFVSF LKEVESPYEV HDYIRAYLGD TSEAKEFAKQ FLERRAKQKA 1200
NQQRQQQQLP QQQQQQPPQQ PPQQPQQQDS VWGMNHSTLH SVFQTNQSNN QQSNFEAVQS 1260
GKKKKKQKMV RADPSLLGFS VNASSERLNM GEIETLDDY 1299 
Gene Ontology
 GO:0008344; P:adult locomotory behavior; IEA:Compara.
 GO:0008219; P:cell death; IEA:UniProtKB-KW.
 GO:0044267; P:cellular protein metabolic process; IEA:Compara.
 GO:0007631; P:feeding behavior; IEA:Compara.
 GO:0048873; P:homeostasis of number of cells within a tissue; IEA:Compara.
 GO:0048009; P:insulin-like growth factor receptor signaling pathway; IEA:Compara.
 GO:0035264; P:multicellular organism growth; IEA:Compara.
 GO:0050881; P:musculoskeletal movement; IEA:Compara.
 GO:0017148; P:negative regulation of translation; IMP:MGI.
 GO:0050885; P:neuromuscular process controlling balance; IEA:Compara.
 GO:0009791; P:post-embryonic development; IEA:Compara.
 GO:0021522; P:spinal cord motor neuron differentiation; IEA:Compara. 
Interpro
 IPR003169; GYF. 
Pfam
 PF02213; GYF 
SMART
 SM00444; GYF 
PROSITE
 PS50829; GYF 
PRINTS