| Tag | Content |
|---|
| CPLM ID | CPLM-004304 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Microtubule-associated protein 2 |
Protein Synonyms/Alias | MAP-2 |
Gene Name | Map2 |
Gene Synonyms/Alias | Mtap2 |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 275 | EMPVESKKDEWGLAA | ubiquitination | [1] | | 797 | SESPFPAKEYYKNGT | ubiquitination | [1] |
|
Reference | [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J. J Proteome Res. 2012 Sep 7;11(9):4722-32. [ PMID: 22871113] |
Functional Description | The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules. |
Sequence Annotation | REPEAT 1664 1694 Tau/MAP 1.
REPEAT 1695 1725 Tau/MAP 2.
REPEAT 1726 1756 Tau/MAP 3.
REPEAT 1757 1788 Tau/MAP 4.
REGION 1454 1474 Calmodulin-binding (Potential).
MOD_RES 610 610 Phosphoserine (By similarity).
MOD_RES 628 628 Phosphoserine (By similarity).
MOD_RES 657 657 Phosphoserine (By similarity).
MOD_RES 732 732 Phosphoserine (By similarity).
MOD_RES 739 739 Phosphoserine (By similarity).
MOD_RES 748 748 Phosphotyrosine (By similarity).
MOD_RES 825 825 Phosphoserine (By similarity).
MOD_RES 1162 1162 Phosphoserine (By similarity).
MOD_RES 1353 1353 Phosphoserine (By similarity).
MOD_RES 1359 1359 Phosphothreonine (By similarity).
MOD_RES 1427 1427 Phosphoserine (By similarity).
MOD_RES 1446 1446 Phosphothreonine (By similarity).
MOD_RES 1487 1487 Phosphoserine (By similarity).
MOD_RES 1541 1541 Phosphoserine (By similarity).
MOD_RES 1597 1597 Phosphoserine (By similarity).
MOD_RES 1600 1600 Phosphothreonine (By similarity).
MOD_RES 1601 1601 Phosphothreonine (By similarity).
MOD_RES 1608 1608 Phosphothreonine (By similarity).
MOD_RES 1611 1611 Phosphothreonine (By similarity).
MOD_RES 1614 1614 Phosphoserine (By similarity).
MOD_RES 1617 1617 Phosphoserine (By similarity).
MOD_RES 1622 1622 Phosphothreonine (By similarity).
MOD_RES 1652 1652 Phosphothreonine (By similarity).
MOD_RES 1659 1659 Phosphothreonine (By similarity).
MOD_RES 1682 1682 Phosphoserine; by PKA and MARK1.
MOD_RES 1744 1744 Phosphoserine; by PKA.
MOD_RES 1776 1776 Phosphoserine; by PKA.
MOD_RES 1816 1816 Phosphoserine (By similarity).
MOD_RES 1824 1824 Phosphoserine (By similarity). |
Keyword | Alternative splicing; Calmodulin-binding; Complete proteome; Cytoplasm; Cytoskeleton; Microtubule; Phosphoprotein; Reference proteome; Repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1861 AA |
Protein Sequence | MADERKDEGK APHWTSASLT EAAAHPHSPE MKDQGGSGEG LSRSANGFPY REEEEGAFGE 60
HGSQGTYSDT KENGINGELT SADRETAEEV SARIVQVVTA EAVAVLKGEQ EKEAQHKDQP 120
AALPLAAEET VNLPPSPPPS PASEQTAALE EDLLTASKME FPEQQKLPSS FAEPLDKEET 180
EFKMQSKPGE DFEHAALVPQ PDTSKTPQDK KDPQDMEGEK SPASPFAQTF GTNLEDIKQI 240
TEPSITVPSI GLSAEPLAPK DQKDWFIEMP VESKKDEWGL AAPISPGPLT PMREKDVLED 300
IPRWEGKQFD SPMPSPFHGG SFTLPLDTVK DERVTEGSQP FAPVFFQSDD KMSLQDTSGS 360
ATSKESSKDE EPQKDKADKV ADVPVSEATT VLGDVHSPAV EGFVGENISG EEKGTTDQEK 420
KETSTPSVQE PTLTETEPQT KLEETSKVSI EETVAKEEES LKLKDDKAGV IQTSTEQSFS 480
KEDQKGQEQT IEALKQDSFP ISLEQAVTDA AMATKTLEKV TSEPEAVSEK REIQGLFEED 540
IADKSKLEGA GSATVAEVEM PFYEDKSGMS KYFETSALKE DVTRSTGLGS DYYELSDSRG 600
NAQESLDTVS PKNQQDEKEL LAKASQPSPP AHEAGYSTLA QSYTSDHPSE LPEEPSSPQE 660
RMFTIDPKVY GEKRDLHSKN KDDLTLSRSL GLGGRSAIEQ RSMSINLPMS CLDSIALGFN 720
FGRGHDLSPL ASDILTNTSG SMDEGDDYLP PTTPAVEKIP CFPIESKEEE DKTEQAKVTG 780
GQTTQVETSS ESPFPAKEYY KNGTVMAPDL PEMLDLAGTR SRLASVSADA EVARRKSVPS 840
EAVVAESSTG LPPVADDSQP VKPDSQLEDM GYCVFNKYTV PLPSPVQDSE NLSGESGSFY 900
EGTDDKVRRD LATDLSLIEV KLAAAGRVKD EFTAEKEASP PSSADKSGLS REFDQDRKAN 960
DKLDTVLEKS EEHVDSKEHA KESEEVGDKV ELFGLGVTYE QTSAKELITT KETAPERAEK 1020
GLSSVPEVAE VETTTKADQG LDVAAKKDDQ SPLDIKVSDF GQMASGMSVD AGKTIELKFE 1080
VDQQLTLSSE APQETDSFMG IESSHVKDGA KVSETEVKEK VAKPDLVHQE AVDKEESYES 1140
SGEHESLTME SLKPDEGKKE TSPETSLIQD EVALKLSVEI PCPPPVSEAD SSIDEKAEVQ 1200
MEFIQLPKEE STETPDIPAI PSDVTQPQPE AVVSEPAEVR GEEEEIEAEG EYDKLLFRSD 1260
TLQITDLLVP GSREEFVETC PGEHKGVVES VVTIEDDFIT VVQTTTDEGE LGSHSVRFAA 1320
PVQPEEERRP YPHDEELEVL MAAEAQAEPK DGSPDAPATP EKEEVPFSEY KTETYDDYKD 1380
ETTIDDSIMD ADSLWVDTQD DDRSILTEQL ETIPKEERAE KEARRPSLEK HRKEKPFKTG 1440
RGRISTPERR EVAKKEPSTV SRDEVRRKKA VYKKAELAKE SEVQAHSPSR KLILKPAIKY 1500
TRPTHLSCVK RKTTATSGES AQAPSAFKQA KDKVTDGITK SPEKRSSLPR PSSILPPRRG 1560
VSGDREENSF SLNSSISSAR RTTRSEPIRR AGKSGTSTPT TPGSTAITPG TPPSYSSRTP 1620
GTPGTPSYPR TPGTPKSGIL VPSEKKVAII RTPPKSPATP KQLRLINQPL PDLKNVKSKI 1680
GSTDNIKYQP KGGQVRILNK KMDFSKVQSR CGSKDNIKHS AGGGNVQIVT KKIDLSHVTS 1740
KCGSLKNIRH RPGGGRVKIE SVKLDFKEKA QAKVGSLDNA HHVPGGGNVK IDSQKLNFRE 1800
HAKARVDHGA EIITQSPSRS SVASPRRLSN VSSSGSINLL ESPQLATLAE DVTAALAKQG 1860
L 1861 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |