UniProt Accession

 F8W7R3_HUMAN; F8W7R3 

Genbank Protein ID

 AC124068 

Genbank Nucleotide ID

  

Protein Name

 Fanconi anemia group I protein 

Protein Synonyms/Alias

  

Gene Name

 FANCI 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
4	****MDQKILSLAAE	ubiquitination	[1, 2, 3]
12	ILSLAAEKTADKLQE	ubiquitination	[3, 4]
16	AAEKTADKLQEFLQT	ubiquitination	[1, 3, 4, 5, 6]
39	LLQNQAVKGKVAGAL	ubiquitination	[1, 2, 3, 4, 5, 6, 7]
41	QNQAVKGKVAGALLR	ubiquitination	[2, 3, 5, 6]
52	ALLRAIFKGSPCSEE	ubiquitination	[1, 2, 3, 5, 6]
125	EGSLVNGKSLELLPI	ubiquitination	[3]
140	ILTALATKKENLAYG	ubiquitination	[7]
141	LTALATKKENLAYGK	ubiquitination	[3]
148	KENLAYGKGVLSGEE	ubiquitination	[3, 5, 6]
157	VLSGEECKKQLINTL	ubiquitination	[3]
158	LSGEECKKQLINTLC	ubiquitination	[3, 6]
331	DQVLDLLKTSVVKSF	ubiquitination	[3, 4, 5, 7]
336	LLKTSVVKSFKDLQL	ubiquitination	[1, 6]
339	TSVVKSFKDLQLLQG	ubiquitination	[1, 3, 4, 5, 6]
348	LQLLQGSKFLQNLVP	ubiquitination	[1, 3, 4, 5, 6]
402	PKKVLDGKTIETSPS	ubiquitination	[1, 2, 3, 4, 5, 6, 7]
420	MPNQHACKLGANILL	ubiquitination	[3, 5]
431	NILLETFKIHEMIRQ	ubiquitination	[3, 5]
501	QTVQRLLKAVQPLLK	ubiquitination	[1, 3, 4, 5, 6, 7]
508	KAVQPLLKVSMSMRD	ubiquitination	[5]
523	CLILVLRKAMFANQL	ubiquitination	[1, 3, 4, 5, 6, 7, 8, 9]
638	LKQFYEPKPDLLPPL	ubiquitination	[1, 4]
715	SITNRMIKSELEDFE	ubiquitination	[1, 3, 4, 5, 6, 7, 9]
725	LEDFELDKSADFSQS	ubiquitination	[4]
780	SLFMCYKKLSDILNE	ubiquitination	[3]
788	LSDILNEKAGKAKTK	ubiquitination	[3, 4, 5]
799	AKTKMANKTSDSLLS	ubiquitination	[3]
837	TSVEESGKKEKGKSI	ubiquitination	[4, 5, 7]
838	SVEESGKKEKGKSIS	ubiquitination	[3, 6]
840	EESGKKEKGKSISLL	ubiquitination	[3]
842	SGKKEKGKSISLLCL	ubiquitination	[2, 3, 5, 6]
866	VQQFYQPKIQQFLRA	ubiquitination	[3, 5, 6]
879	RALDVTDKEGEERED	ubiquitination	[3, 4, 6]
952	QMLSWTSKICKENSR	ubiquitination	[5]
955	SWTSKICKENSREDA	ubiquitination	[3]
1008	DQDVEVEKTNHFAIV	ubiquitination	[3, 5]
1045	EVDWLITKLKGQVSQ	ubiquitination	[1, 4, 5, 6, 7]
1047	DWLITKLKGQVSQET	ubiquitination	[7]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [5] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [6] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [7] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [8] Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level.
 Danielsen JM, Sylvestersen KB, Bekker-Jensen S, Szklarczyk D, Poulsen JW, Horn H, Jensen LJ, Mailand N, Nielsen ML.
 Mol Cell Proteomics. 2011 Mar;10(3):M110.003590. [PMID: 21139048]
 [9] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 1095 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IDA:HPA.
 GO:0005886; C:plasma membrane; IDA:HPA.
 GO:0006281; P:DNA repair; IEA:InterPro. 

Interpro

 IPR026171; FANCI. 

Pfam

  

SMART

  

PROSITE

  

PRINTS