UniProt Accession

 CP3A4_HUMAN; P08684; P05184; Q16757; Q9UK50 

Genbank Protein ID

 D00003; M13785; M18907; M14096; X12387; J04449; AF182273; AF280107; AF209389 

Genbank Nucleotide ID

 BAA00001.1; AAA35742.1; AAA35745.1; AAA35744.1; CAA30944.1; AAA35747.1; AAF13598.1; AAG32290.1; AAF21034.1 

Protein Name

 Cytochrome P450 3A4 

Protein Synonyms/Alias

 1,8-cineole 2-exo-monooxygenase; Albendazole monooxygenase; Albendazole sulfoxidase; CYPIIIA3; CYPIIIA4; Cytochrome P450 3A3; Cytochrome P450 HLp; Cytochrome P450 NF-25; Cytochrome P450-PCN1; Nifedipine oxidase; Quinine 3-monooxygenase; Taurochenodeoxycholate 6-alpha-hydroxylase 

Gene Name

 CYP3A4 

Gene Synonyms/Alias

 CYP3A3 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
127	IAEDEEWKRLRSLLS	acetylation	[1]
413	KYWTEPEKFLPERFS	acetylation	[1]

Reference

 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 

Functional Description

 Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4- hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,8-cineole 2- exo-monooxygenase. The enzyme also hydroxylates etoposide. 

Sequence Annotation

 METAL 442 442 Iron (heme axial ligand).  

Keyword

 3D-structure; Complete proteome; Direct protein sequencing; Endoplasmic reticulum; Heme; Iron; Membrane; Metal-binding; Microsome; Monooxygenase; NADP; Oxidoreductase; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 503 AA 

Protein Sequence

Gene Ontology

 GO:0009986; C:cell surface; IDA:UniProtKB.
 GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0047638; F:albendazole monooxygenase activity; IEA:EC.
 GO:0034875; F:caffeine oxidase activity; IDA:BHF-UCL.
 GO:0009055; F:electron carrier activity; IEA:InterPro.
 GO:0020037; F:heme binding; IEA:InterPro.
 GO:0005506; F:iron ion binding; IDA:BHF-UCL.
 GO:0016712; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; IEA:InterPro.
 GO:0019825; F:oxygen binding; TAS:ProtInc.
 GO:0050591; F:quinine 3-monooxygenase activity; IEA:EC.
 GO:0005496; F:steroid binding; IDA:BHF-UCL.
 GO:0033780; F:taurochenodeoxycholate 6alpha-hydroxylase activity; IEA:EC.
 GO:0050649; F:testosterone 6-beta-hydroxylase activity; IMP:BHF-UCL.
 GO:0070576; F:vitamin D 24-hydroxylase activity; IDA:BHF-UCL.
 GO:0030343; F:vitamin D3 25-hydroxylase activity; IDA:BHF-UCL.
 GO:0009822; P:alkaloid catabolic process; IDA:BHF-UCL.
 GO:0008209; P:androgen metabolic process; TAS:BHF-UCL.
 GO:0042738; P:exogenous drug catabolic process; IDA:BHF-UCL.
 GO:0046483; P:heterocycle metabolic process; IDA:BHF-UCL.
 GO:0016098; P:monoterpenoid metabolic process; IDA:BHF-UCL.
 GO:0070989; P:oxidative demethylation; IDA:BHF-UCL.
 GO:0006706; P:steroid catabolic process; IMP:BHF-UCL.
 GO:0006805; P:xenobiotic metabolic process; TAS:Reactome. 

Interpro

 IPR001128; Cyt_P450.
 IPR017972; Cyt_P450_CS.
 IPR008072; Cyt_P450_E_CYP3A.
 IPR002402; Cyt_P450_E_grp-II. 

Pfam

 PF00067; p450 

SMART

  

PROSITE

 PS00086; CYTOCHROME_P450 

PRINTS

 PR00464; EP450II.
 PR01689; EP450IICYP3A.
 PR00385; P450.