CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039937
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Mediator of RNA polymerase II transcription subunit 23 
Protein Synonyms/Alias
  
Gene Name
 MED23 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
106LQQSLRNKSLQMNDYubiquitination[1, 2, 3]
314TRFLSDPKTVLSAESubiquitination[1, 2, 3, 4]
399ESRFNLKKNVEEEYRubiquitination[2]
546NRVSDFVKENSPEHWubiquitination[2]
691CLSDTYLKCAMNAREubiquitination[2]
723LVDTMAGKSPGPFPNubiquitination[2, 3]
773ALLNVVLKSQPLVPRubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1009 AA 
Protein Sequence
MERSETEEKF DDGGTSQLLW QHLSSQLIFF VLFQFASFPH MVLSLHQKYI PVPDINKPQS 60
THAFAMTCIW IHLNRKAQND NSKLQIPIPH SLRLHHEFLQ QSLRNKSLQM NDYKIALLCN 120
AYSTNSECFT LPMGALVETI YGNGIMRIPL PGTNCMASGS ITPLPMNLLD SLTVHAKMSL 180
IHSIATRVIK LAHAKSSVAL APALVETYSR LLVYMEIESL GIKGFISQLL PTVFKSHAWG 240
ILHTLLEMFS YRMHHIQPHY RVQLLSHLHT LAAVAQTNQN QLHLCVESTA LRLITALGSS 300
EVQPQFTRFL SDPKTVLSAE SEELNRALIL TLARATHVTD FFTGSDSIQG TWCKDILQTI 360
MSFTPHNWAS HTLSCFPGPL QAFFKQNNVP QESRFNLKKN VEEEYRKWKS MSNENDIITH 420
FSMQGSPPLF LCLLWKMLLE TDHINQIGYR VLERIGARAL VAHVRTFADF LVYEFSTSAG 480
GQQLNKCIEI LNDMVWKYNI VTLDRLILCL AMRSHEGNEA QVCYFIIQLL LLKPNDFRNR 540
VSDFVKENSP EHWLQNDWHT KHMNYHKKYP EKLYFEGLAE QVDPPVQIQS PYLPIYFGNV 600
CLRFLPVFDI VIHRFLELLP VSKSLETLLD HLGGLYKFHD RPVTYLYNTL HYYEMHLRDR 660
AFLKRKLVHA IIGSLKDNRP QGWCLSDTYL KCAMNAREEN PWVPDDTYYC RLIGRLVDTM 720
AGKSPGPFPN CDWRFNEFPN PAAHALHVTC VELMALAVSG KEVGNALLNV VLKSQPLVPR 780
ENITAWMNAI GLIITALPEP YWIVLHDRIV SVISSPSLTS ETEWVGYPFR LFDFTACHQS 840
YSEMSCSYTL ALAHAVWHHS SIGQLSLIPK FLTEVLLPIV KTEFQLLYVY HLVGPFLQRF 900
QQERTRCMIE IGVAFYDMLL NVDQCSTHLN YMDPICDFLY HMKYMFTGDS VKEQVEKIIC 960
NLKPALKLRL RFITHISKME PAAVPPQAMN SGSPAPQSNQ VPVSLPVTQ 1009 
Gene Ontology
  
Interpro
 IPR021629; Mediator_Med23. 
Pfam
 PF11573; Med23 
SMART
  
PROSITE
  
PRINTS