CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-040920
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Nebulin 
Protein Synonyms/Alias
  
Gene Name
 NEB 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
1994IMNEHLYKQAWEADKubiquitination[1]
6236RSALNYRKHYEDTKAmethylation[2]
6242RKHYEDTKANVHIPNmethylation[2]
7602TELQSIVKYKEKYEKubiquitination[3]
Reference
 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [2] Large-scale global identification of protein lysine methylation in vivo.
 Cao XJ, Arnaudo AM, Garcia BA.
 Epigenetics. 2013 May 1;8(5):477-85. [PMID: 23644510]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome; SH3 domain. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 8525 AA 
Protein Sequence
MADDEDYEEV VEYYTEEVVY EEVPGETITK IYETTTTRTS DYEQSETSKP ALAQPALAQP 60
ASAKPVERRK VIRKKVDPSK FMTPYIAHSQ KMQDLFSPNK YKEKFEKTKG QPYASTTDTP 120
ELRRIKKVQD QLSEVKYRMD GDVAKTICHV DEKAKDIEHA KKVSQQVSKV LYKQNWEDTK 180
DKYLLPPDAP ELVQAVKNTA MFSKKLYTED WEADKSLFYP YNDSPELRRV AQAQKALSDV 240
AYKKGLAEQQ AQFTPLADPP DIEFAKKVTN QVSKQKYKED YENKIKGKWS ETPCFEVANA 300
RMNADNISTR KYQEDFENMK DQIYFMQTET PEYKMNKKAG VAASKVKYKE DYEKNKGKAD 360
YNVLPASENP QLRQLKAAGD ALSDKLYKEN YEKTKAKSIN YCETPKFKLD TVLQNFSSDK 420
KYKDSYLKDI LGHYVGSFED PYHSHCMKVT AQNSDKNYKA EYEEDRGKGF FPQTITQEYE 480
AIKKLDQCKD HTYKVHPDKT KFTQVTDSPV LLQAQVNSKQ LSDLNYKAKH ESEKFKCHIP 540
PDTPAFIQHK VNAYNLSDNL YKQDWEKSKA KKFDIKVDAI PLLAAKANTK NTSDVMYKKD 600
YEKNKGKMIG VLSINDDPKM LHSLKVAKNQ SDRLYKENYE KTKAKSMNYC ETPKYQLDTQ 660
LKNFSEARYK DLYVKDVLGH YVGSMEDPYH THCMKVAAQN SDKSYKAEYE EDKGKCYFPQ 720
TITQEYEAIK KLDQCKDHTY KVHPDKTKFT AVTDSPVLLQ AQLNTKQLSD LNYKAKHEGE 780
KFKCHIPADA PQFIQHRVNA YNLSDNVYKQ DWEKSKAKKF DIKVDAIPLL AAKANTKNTS 840
DVMYKKDYEK SKGKMIGALS INDDPKMLHS LKTAKNQSDR EYRKDYEKSK TIYTAPLDML 900
QVTQAKKSQA IASDVDYKHI LHSYSYPPDS INVDLAKKAY ALQSDVEYKA DYNSWMKGCG 960
WVPFGSLEME KAKRASDILN EKKYRQHPDT LKFTSIEDAP ITVQSKINQA QRSDIAYKAK 1020
GEEIIHKYNL PPDLPQFIQA KVNAYNISEN MYKADLKDLS KKGYDLRTDA IPIRAAKAAR 1080
QAASDVQYKK DYEKAKGKMV GFQSLQDDPK LVHYMNVAKI QSDREYKKDY EKTKSKYNTP 1140
HDMFNVVAAK KAQDVVSNVN YKHSLHHYTY LPDAMDLELS KNMMQIQSDN VYKEDYNNWM 1200
KGIGWIPIGS LDVEKVKKAG DALNEKKYRQ HPDTLKFTSI VDSPVMVQAK QNTKQVSDIL 1260
YKAKGEDVKH KYTMSPDLPQ FLQAKCNAYN ISDVCYKRDW YDLIAKGNNV LGDAIPITAA 1320
KASRNIASDY KYKEAYEKSK GKHVGFRSLQ DDPKLVHYMN VAKLQSDREY KKNYENTKTS 1380
YHTPGDMVSI TAAKMAQDVA TNVNYKQPLH HYTYLPDAMS LEHTRNVNQI QSDNVYKDEY 1440
NSFLKGIGWI PIGSLEVEKV KKAGDALNER KYRQHPDTVK FTSVPDSMGM VLAQHNTKQL 1500
SDLNYKVEGE KLKHKYTIDP ELPQFIQAKV NALNMSDAHY KADWKKTIAK GYDLRPDAIP 1560
IVAAKSSRNI ASDCKYKEAY EKAKGKQVGF LSLQDDPKLV HYMNVAKIQS DREYKKGYEA 1620
SKTKYHTPLD MVSVTAAKKS QEVATNANYR QSYHHYTLLP DALNVEHSRN AMQIQSDNLY 1680
KSDFTNWMKG IGWVPIESLE VEKAKKAGEI LSEKKYRQHP EKLKFTYAMD TMEQALNKSN 1740
KLNMDKRLYT EKWNKDKTTI HVMPDTPDIL LSRVNQITMS DKLYKAGWEE EKKKGYDLRP 1800
DAIAIKAARA SRDIASDYKY KKAYEQAKGK HIGFRSLEDD PKLVHFMQVA KMQSDREYKK 1860
GYEKSKTSFH TPVDMLSVVA AKKSQEVATN ANYRNVIHTY NMLPDAMSFE LAKNMMQIQS 1920
DNQYKADYAD FMKGIGWLPL GSLEAEKNKK AMEIISEKKY RQHPDTLKYS TLMDSMNMVL 1980
AQNNAKIMNE HLYKQAWEAD KTKVHIMPDI PQIILAKANA INMSDKLYKL SLEESKKKGY 2040
DLRPDAIPIK AAKASRDIAS DYKYKYNYEK GKGKMVGFRS LEDDPKLVHS MQVAKMQSDR 2100
EYKKNYENTK TSYHTPADML SVTAAKDAQA NITNTNYKHL IHKYILLPDA MNIELTRNMN 2160
RIQSDNEYKQ DYNEWYKGLG WSPAGSLEVE KAKKATEYAS DQKYRQHPSN FQFKKLTDSM 2220
DMVLAKQNAH TMNKHLYTID WNKDKTKIHV MPDTPDILQA KQNQTLYSQK LYKLGWEEAL 2280
KKGYDLPVDA ISVQLAKASR DIASDYKYKQ GYRKQLGHHV GFRSLQDDPK LVLSMNVAKM 2340
QSEREYKKDF EKWKTKFSSP VDMLGVVLAK KCQELVSDVD YKNYLHQWTC LPDQNDVVQA 2400
KKVYELQSEN LYKSDLEWLR GIGWSPLGSL EAEKNKRASE IISEKKYRQP PDRNKFTSIP 2460
DAMDIVLAKT NAKNRSDRLY REAWDKDKTQ IHIMPDTPDI VLAKANLINT SDKLYRMGYE 2520
ELKRKGYDLP VDAIPIKAAK ASREIASEYK YKEGFRKQLG HHIGARNIED DPKMMWSMHV 2580
AKIQSDREYK KDFEKWKTKF SSPVDMLGVV LAKKCQTLVS DVDYKNYLHQ WTCLPDQSDV 2640
IHARQAYDLQ SDNLYKSDLQ WLKGIGWMTS GSLEDEKNKR ATQILSDHVY RQHPDQFKFS 2700
SLMDSIPMVL AKNNAITMNH RLYTEAWDKD KTTVHIMPDT PEVLLAKQNK VNYSEKLYKL 2760
GLEEAKRKGY DMRVDAIPIK AAKASRDIAS EFKYKEGYRK QLGHHIGARA IRDDPKMMWS 2820
MHVAKIQSDR EYKKDFEKWK TKFSSPVDML GVVLAKKCQT LVSDVDYKNY LHQWTCLPDQ 2880
SDVIHARQAY DLQSDNMYKS DLQWMRGIGW VSIGSLDVEK CKRATEILSD KIYRQPPDRF 2940
KFTSVTDSLE QVLAKNNAIT MNKRLYTEAW DKDKTQIHIM PDTPEIMLAR MNKINYSESL 3000
YKLANEEAKK KGYDLRSDAI PIVAAKASRD IISDYKYKDG YCKQLGHHIG ARNIEDDPKM 3060
MWSMHVAKIQ SDREYKKDFE KWKTKFSSPV DMLGVVLAKK CQTLVSDVDY KNYLHEWTCL 3120
PDQSDVIHAR QAYDLQSDNI YKSDLQWLRG IGWVPIGSMD VVKCKRATEI LSDNIYRQPP 3180
DKLKFTSVTD SLEQVLAKNN ALNMNKRLYT EAWDKDKTQI HIMPDTPEIM LARQNKINYS 3240
ETLYKLANEE AKKKGYDLRS DAIPIVAAKA SRDVISDYKY KDGYRKQLGH HIGARNIEDD 3300
PKMMWSMHVA KIQSDREYKK DFEKWKTKFS SPVDMLGVVL AKKCQTLVSD VDYKNYLHEW 3360
TCLPDQNDVI HARQAYDLQS DNIYKSDLQW LRGIGWVPIG SMDVVKCKRA AEILSDNIYR 3420
QPPDKLKFTS VTDSLEQVLA KNNALNMNKR LYTEAWDKDK TQVHIMPDTP EIMLARQNKI 3480
NYSESLYRQA MEEAKKEGYD LRSDAIPIVA AKASRDIASD YKYKEAYRKQ LGHHIGARAV 3540
HDDPKIMWSL HIAKVQSDRE YKKDFEKYKT RYSSPVDMLG IVLAKKCQTL VSDVDYKHPL 3600
HEWICLPDQN DIIHARKAYD LQSDNLYKSD LEWMKGIGWV PIDSLEVVRA KRAGELLSDT 3660
IYRQRPETLK FTSITDTPEQ VLAKNNALNM NKRLYTEAWD NDKKTIHVMP DTPEIMLAKL 3720
NRINYSDKLY KLALEESKKE GYDLRLDAIP IQAAKASRDI ASDYKYKEGY RKQLGHHIGA 3780
RNIKDDPKMM WSIHVAKIQS DREYKKEFEK WKTKFSSPVD MLGVVLAKKC QILVSDIDYK 3840
HPLHEWTCLP DQNDVIQARK AYDLQSDAIY KSDLEWLRGI GWVPIGSVEV EKVKRAGEIL 3900
SDRKYRQPAD QLKFTCITDT PEIVLAKNNA LTMSKHLYTE AWDADKTSIH VMPDTPDILL 3960
AKSNSANISQ KLYTKGWDES KMKDYDLRAD AISIKSAKAS RDIASDYKYK EAYEKQKGHH 4020
IGAQSIEDDP KIMCAIHAGK IQSEREYKKE FQKWKTKFSS PVDMLSILLA KKCQTLVTDI 4080
DYRNYLHEWT CMPDQNDIIQ AKKAYDLQSD SVYKADLEWL RGIGWMPEGS VEMNRVKVAQ 4140
DLVNERLYRT RPEALSFTSI VDTPEVVLAK ANSLQISEKL YQEAWNKDKS NITIPSDTPE 4200
MLQAHINALQ ISNKLYQKDW NDAKQKGYDI RADAIEIKHA KASREIASEY KYKEGYRKQL 4260
GHHMGFRTLQ DDPKSVWAIH AAKIQSDREY KKAYEKSKGI HNTPLDMMSI VQAKKCQVLV 4320
SDIDYRNYLH QWTCLPDQND VIQAKKAYDL QSDNLYKSDL EWLKGIGWLP EGSVEVMRVK 4380
NAQNLLNERL YRIKPEALKF TSIVDTPEVI QAKINAVQIS EPLYRDAWEK EKANVNVPAD 4440
TPLMLQSKIN ALQISNKRYQ QAWEDVKMTG YDLRADAIGI QHAKASRDIA SDYLYKTAYE 4500
KQKGHYIGCR SAKEDPKLVW AANVLKMQND RLYKKAYNDH KAKISIPVDM VSISAAKEGQ 4560
ALASDVDYRH YLHHWSCFPD QNDVIQARKA YDLQSDSVYK ADLEWLRGIG WMPEGSVEMN 4620
RVKVAQDLVN ERLYRTRPEA LSFTSIVDTP EVVLAKANSL QISEKLYQEA WNKDKSNITI 4680
PSDTPEMLQA HINALQISNK LYQKDWNDTK QKGYDIRADA IEIKHAKASR EIASEYKYKE 4740
GYRKQLGHHM GFRTLQDDPK SVWAIHAAKI QSDREYKKAY EKSKGIHNTP LDMMSIVQAK 4800
KCQVLVSDID YRNYLHQWTC LPDQNDVIQA KKAYDLQSDN LYKSDLEWLK GIGWLPEGSV 4860
EVMRVKNAQN LLNERLYRIK PEALKFTSIV DTPEVIQAKI NAVQISEPLY RNAWEKEKAN 4920
VNVPADTPLM LQSKINALQI SNKRYQQAWE DVKMTGYDLR ADAIGIQHAK ASRDIASDYL 4980
YKTAYEKQKG HYIGCRSAKE DPKLVWAANV LKMQNDRLYK KAYNDHKAKI SIPVDMVSIS 5040
AAKEGQALAS DVDYRHYLHH WSCFPDQNDV IQARKAYDLQ SDSVYKADLE WLRGIGWMPE 5100
GSVEMNRVKV AQDLVNERLY RTRPEALSFT SIVDTPEVVL AKANSLQISE KLYQEAWNKD 5160
KSNITIPSDT PEMLQAHINA LQISNKLYQK DWNDTKQKGY DIRADAIEIK HAKASREIAS 5220
EYKYKEGYRK QLGHHMGFRT LQDDPKSVWA IHAAKIQSDR EYKKAYEKSK GIHNTPLDMM 5280
SIVQAKKCQV LVSDIDYRNY LHQWTCLPDQ NDVIQAKKAY DLQSDNLYKS DLEWLKGIGW 5340
LPEGSVEVMR VKNAQNLLNE RLYRIKPEAL KFTSIVDTPE VIQAKINAVQ ISEPLYRDAW 5400
EKEKANVNVP ADTPLMLQSK INALQISNKR YQQAWEDVKM TGYDLRADAI GIQHAKASRD 5460
IASDYLYKTA YEKQKGHYIG CRSAKEDPKL VWAANVLKMQ NDRLYKKAYN DHKAKISIPV 5520
DMVSISAAKE GQALASDVDY RHYLHRWSCF PDQNDVIQAR KAYDLQSDAL YKADLEWLRG 5580
IGWMPQGSPE VLRVKNAQNI FCDSVYRTPV VNLKYTSIVD TPEVVLAKSN AENISIPKYR 5640
EVWDKDKTSI HIMPDTPEIN LARANALNVS NKLYREGWDE MKAGCDVRLD AIPIQAAKAS 5700
REIASDYKYK LDHEKQKGHY VGTLTARDDN KIRWALIADK LQNEREYRLD WAKWKAKIQS 5760
PVDMLSILHS KNSQALVSDM DYRNYLHQWT CMPDQNDVIQ AKKAYELQSD NVYKADLEWL 5820
RGIGWMPNDS VSVNHAKHAA DIFSEKKYRT KIETLNFTPV DDRVDYVTAK QSGEILDDIK 5880
YRKDWNATKS KYTLTETPLL HTAQEAARIL DQYLYKEGWE RQKATGYILP PDAVPFVHAH 5940
HCNDVQSELK YKAEHVKQKG HYVGVPTMRD DPKLVWFEHA GQIQNERLYK EDYHKTKAKI 6000
NIPADMVSVL AAKQGQTLVS DIDYRNYLHQ WMCHPDQNDV IQARKAYDLQ SDNVYRADLE 6060
WLRGIGWIPL DSVDHVRVTK NQEMMSQIKY KKNALENYPN FRSVVDPPEI VLAKINSVNQ 6120
SDVKYKETFN KAKGKYTFSP DTPHISHSKD MGKLYSTILY KGAWEGTKAY GYTLDERYIP 6180
IVGAKHADLV NSELKYKETY EKQKGHYLAG KVIGEFPGVV HCLDFQKMRS ALNYRKHYED 6240
TKANVHIPND MMNHVLAKRC QYILSDLEYR HYFHQWTSLL EEPNVIRVRN AQEILSDNVY 6300
KDDLNWLKGI GCYVWDTPQI LHAKKSYDLQ SQLQYTAAGK ENLQNYNLVT DTPLYVTAVQ 6360
SGINASEVKY KENYHQIKDK YTTVLETVDY DRTRNLKNLY SSNLYKEAWD RVKATSYILP 6420
SSTLSLTHAK NQKHLASHIK YREEYEKFKA LYTLPRSVDD DPNTARCLRV GKLNIDRLYR 6480
SVYEKNKMKI HIVPDMVEMV TAKDSQKKVS EIDYRLRLHE WICHPDLQVN DHVRKVTDQI 6540
SDIVYKDDLN WLKGIGCYVW DTPEILHAKH AYDLRDDIKY KAHMLKTRND YKLVTDTPVY 6600
VQAVKSGKQL SDAVYHYDYV HSVRGKVAPT TKTVDLDRAL HAYKLQSSNL YKTSLRTLPT 6660
GYRLPGDTPH FKHIKDTRYM SSYFKYKEAY EHTKAYGYTL GPKDVPFVHV RRVNNVTSER 6720
LYRELYHKLK DKIHTTPDTP EIRQVKKTQE AVSELIYKSD FFKMQGHMIS LPYTPQVIHC 6780
RYVGDITSDI KYKEDLQVLK GFGCFLYDTP DMVRSRHLRK LWSNYLYTDK ARKMRDKYKV 6840
VLDTPEYRKV QELKTHLSEL VYRAAGKKQK SIFTSVPDTP DLLRAKRGQK LQSQYLYVEL 6900
ATKERPHHHA GNQTTALKHA KDVKDMVSEK KYKIQYEKMK DKYTPVPDTP ILIRAKRAYW 6960
NASDLRYKET FQKTKGKYHT VKDALDIVYH RKVTDDISKI KYKENYMSQL GIWRSIPDRP 7020
EHFHHRAVTD TVSDVKYKED LTWLKGIGCY AYDTPDFTLA EKNKTLYSKY KYKEVFERTK 7080
SDFKYVADSP INRHFKYATQ LMNERKYKSS AKMFLQHGCN EILRPDMLTA LYNSHMWSQI 7140
KYRKNYEKSK DKFTSIVDTP EHLRTTKVNK QISDILYKLE YNKAKPRGYT TIHDTPMLLH 7200
VRKVKDEVSD LKYKEVYQRN KSNCTIEPDA VHIKAAKDAY KVNTNLDYKK QYEANKAHWK 7260
WTPDRPDFLQ AAKSSLQQSD FEYKLDREFL KGCKLSVTDD KNTVLALRNT LIESDLKYKE 7320
KHVKERGTCH AVPDTPQILL AKTVSNLVSE NKYKDHVKKH LAQGSYTTLP ETRDTVHVKE 7380
VTKHVSDTNY KKKFVKEKGK SNYSIMLEPP EVKHAMEVAK KQSDVAYRKD AKENLHYTTV 7440
ADRPDIKKAT QAAKQASEVE YRAKHRKEGS HGLSMLGRPD IEMAKKAAKL SSQVKYRENF 7500
DKEKGKTPKY NPKDSQLYKV MKDANNLASE VKYKADLKKL HKPVTDMKES LIMNHVLNTS 7560
QLASSYQYKK KYEKSKGHYH TIPDNLEQLH LKEATELQSI VKYKEKYEKE RGKPMLDFET 7620
PTYITAKESQ QMQSGKEYRK DYEESIKGRN LTGLEVTPAL LHVKYATKIA SEKEYRKDLE 7680
ESIRGKGLTE MEDTPDMLRA KNATQILNEK EYKRDLELEV KGRGLNAMAN ETPDFMRARN 7740
ATDIASQIKY KQSAEMEKAN FTSVVDTPEI IHAQQVKNLS SQKKYKEDAE KSMSYYETVL 7800
DTPEIQRVRE NQKNFSLLQY QCDLKNSKGK ITVVQDTPEI LRVKENQKNF SSVLYKEDVS 7860
PGTAIGKTPE MMRVKQTQDH ISSVKYKEAI GQGTPIPDLP EVKRVKETQK HISSVMYKEN 7920
LGTGIPTTVT PEIERVKRNQ ENFSSVLYKE NLGKGIPTPI TPEMERVKRN QENFSSILYK 7980
ENLSKGTPLP VTPEMERVKL NQENFSSVLY KENVGKGIPI PITPEMERVK HNQENFSSVL 8040
YKENLGTGIP IPITPEMQRV KHNQENLSSV LYKENMGKGT PLPVTPEMER VKHNQENISS 8100
VLYKENMGKG TPLPVTPEME RVKHNQENIS SVLYKENMGK GTPLAVTPEM ERVKHNQENI 8160
SSVLYKENVG KATATPVTPE MQRVKRNQEN ISSVLYKENL GKATPTPFTP EMERVKRNQE 8220
NFSSVLYKEN MRKATPTPVT PEMERAKRNQ ENISSVLYSD SFRKQIQGKA AYVLDTPEMR 8280
RVRETQRHIS TVKYHEDFEK HKGCFTPVVT DPITERVKKN MQDFSDINYR GIQRKVVEME 8340
QKRNDQDQET ITGLRVWRTN PGSVFDYDPA EDNIQSRSLH MINVQAQRRS REQSRSASAL 8400
SISGGEEKSE HSEAPDHHLS TYSDGGVFAV STAYKHAKTT ELPQQRSSSV ATQQTTVSSI 8460
PSHPSTAGKI FRAMYDYMAA DADEVSFKDG DAIINVQAID EGWMYGTVQR TGRTGMLPAN 8520
YVEAI 8525 
Gene Ontology
 GO:0030018; C:Z disc; IEA:Compara. 
Interpro
 IPR013998; Nebulin.
 IPR000900; Nebulin_35r-motif.
 IPR001452; SH3_domain. 
Pfam
 PF00880; Nebulin
 PF00018; SH3_1 
SMART
 SM00227; NEBU
 SM00326; SH3 
PROSITE
 PS51216; NEBULIN
 PS50002; SH3 
PRINTS
 PR00510; NEBULIN.