CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022543
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 ABI gene family member 3 
Protein Synonyms/Alias
 New molecule including SH3; Nesh 
Gene Name
 ABI3 
Gene Synonyms/Alias
 NESH 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
43NYVQATDKRKALEETubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961
Functional Description
 May inhibit tumor metastasis (By similarity). In vitro, reduces cell motility. 
Sequence Annotation
 DOMAIN 308 366 SH3.  
Keyword
 Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; Phosphoprotein; Polymorphism; Reference proteome; SH3 domain. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 366 AA 
Protein Sequence
MAELQQLQEF EIPTGREALR GNHSALLRVA DYCEDNYVQA TDKRKALEET MAFTTQALAS 60
VAYQVGNLAG HTLRMLDLQG AALRQVEARV STLGQMVNMH MEKVARREIG TLATVQRLPP 120
GQKVIAPENL PPLTPYCRRP LNFGCLDDIG HGIKDLSTQL SRTGTLSRKS IKAPATPASA 180
TLGRPPRIPE PVHLPVVPDG RLSAASSAFS LASAGSAEGV GGAPTPKGQA APPAPPLPSS 240
LDPPPPPAAV EVFQRPPTLE ELSPPPPDEE LPLPLDLPPP PPLDGDELGL PPPPPGFGPD 300
EPSWVPASYL EKVVTLYPYT SQKDNELSFS EGTVICVTRR YSDGWCEGVS SEGTGFFPGN 360
YVEPSC 366 
Gene Ontology
 GO:0005737; C:cytoplasm; NAS:UniProtKB.
 GO:0030027; C:lamellipodium; IDA:MGI.
 GO:0006928; P:cellular component movement; NAS:UniProtKB.
 GO:0030334; P:regulation of cell migration; IDA:MGI. 
Interpro
 IPR012849; Abl-interactor_HHR_dom.
 IPR001452; SH3_domain. 
Pfam
 PF07815; Abi_HHR
 PF00018; SH3_1 
SMART
 SM00326; SH3 
PROSITE
 PS50002; SH3 
PRINTS
 PR00452; SH3DOMAIN.