| Tag | Content |
|---|
| CPLM ID | CPLM-022090 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Transmembrane protease serine 4 |
Protein Synonyms/Alias | Channel-activating protease 2; CAPH2; Membrane-type serine protease 2; MT-SP2 |
Gene Name | TMPRSS4 |
Gene Synonyms/Alias | TMPRSS3; UNQ776/PRO1570 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 31 | IPMETFRKVGIPIII | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | Probable protease. Seems to be capable of activating ENaC (By similarity). |
Sequence Annotation | DOMAIN 61 93 LDL-receptor class A.
DOMAIN 94 204 SRCR.
DOMAIN 205 434 Peptidase S1.
ACT_SITE 245 245 Charge relay system (By similarity).
ACT_SITE 290 290 Charge relay system (By similarity).
ACT_SITE 387 387 Charge relay system (By similarity).
CARBOHYD 130 130 N-linked (GlcNAc...) (Potential).
CARBOHYD 178 178 N-linked (GlcNAc...) (Potential).
DISULFID 64 83 By similarity.
DISULFID 77 92 By similarity.
DISULFID 127 183 By similarity.
DISULFID 140 193 By similarity.
DISULFID 196 310 By similarity.
DISULFID 230 246 By similarity.
DISULFID 356 372 By similarity.
DISULFID 383 410 By similarity. |
Keyword | Alternative splicing; Complete proteome; Disulfide bond; Glycoprotein; Hydrolase; Membrane; Polymorphism; Protease; Reference proteome; Serine protease; Signal-anchor; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 437 AA |
Protein Sequence | MLQDPDSDQP LNSLDVKPLR KPRIPMETFR KVGIPIIIAL LSLASIIIVV VLIKVILDKY 60
YFLCGQPLHF IPRKQLCDGE LDCPLGEDEE HCVKSFPEGP AVAVRLSKDR STLQVLDSAT 120
GNWFSACFDN FTEALAETAC RQMGYSRAVE IGPDQDLDVV EITENSQELR MRNSSGPCLS 180
GSLVSLHCLA CGKSLKTPRV VGVEEASVDS WPWQVSIQYD KQHVCGGSIL DPHWVLTAAH 240
CFRKHTDVFN WKVRAGSDKL GSFPSLAVAK IIIIEFNPMY PKDNDIALMK LQFPLTFSGT 300
VRPICLPFFD EELTPATPLW IIGWGFTKQN GGKMSDILLQ ASVQVIDSTR CNADDAYQGE 360
VTEKMMCAGI PEGGVDTCQG DSGGPLMYQS DQWHVVGIVS WGYGCGGPST PGVYTKVSAY 420
LNWIYNVWKA EL 432 |
Gene Ontology | GO:0016021; C:integral to membrane; NAS:UniProtKB. GO:0005044; F:scavenger receptor activity; IEA:InterPro. GO:0004252; F:serine-type endopeptidase activity; NAS:UniProtKB. GO:0006508; P:proteolysis; NAS:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |